Therapeutics News and Research

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Breathlessness and fatigue most common in self reported long-COVID

A new systematic review and meta-analysis posted to the medRxiv* preprint server has focussed on investigating the respiratory outcomes and functional recovery of patients eight weeks post-hospitalization with COVID-19 disease.

24 Mar 2022

New therapy makes immunologically 'cold' tumors hot enough for immune attack

Pancreatic cancer is notoriously difficult to cure or even treat. Now, a new strategy devised by scientists at Albert Einstein College of Medicine has succeeded in making pancreatic tumors visible to the immune systems of mice and vulnerable to immune attack, reducing cancer metastases by 87%.

23 Mar 2022

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

A multicenter research team co-led by The University of Texas MD Anderson Cancer Center developed the first drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), as well as lung disease resulting from cancer and cancer treatment.

23 Mar 2022

Researcher wins three NIH grants to tackle mosquito-borne viruses

West Nile virus, Usutu virus, Zika virus, and St. Louis encephalitis virus are all transmitted by mosquitoes and cause a significant threat to human health.

23 Mar 2022

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Of the estimated five million patients in the U.S. diagnosed with heart failure annually, nearly half will have heart failure with preserved ejection fraction (HFpEF). Also known as diastolic heart failure, HFpEF occurs when the heart's lower left chamber loses its ability to relax and fill up with enough blood in between in each heartbeat.

23 Mar 2022

Investigators create specialized, tissue-like structures to model barrier tissues

Investigators at the Brigham and the Broad Institute have created specialized, tissue-like structures in the laboratory to model barrier tissues, such as the intestines, to identify new targets for treatment. Barrier tissues are exposed to substances from the outside world but serve as a layer of protection.

23 Mar 2022

Importance of Numb-associated kinases in SARS-CoV-2 infection

A new study posted to the bioRxiv* preprint server has focussed on assessing four members of the NAK family that are associated with SARS-CoV-2 infection. These kininases could act as a target for the development of effective COVID-19 therapeutics.

23 Mar 2022

Study reveals differences in SARS-CoV-2 and SARS-CoV-1 spike protein conformational changes

Researchers determine the differential dynamic behavior of SARS-CoV-1 and SARS-CoV-2 spike proteins.

22 Mar 2022

Comparing outcomes of modern cementless knee implant with standard knee replacement surgery

Cementless knee replacement, an alternative approach to traditional cemented knee replacement surgery, is garnering interest in the field of orthopedic surgery.

22 Mar 2022

Study finds lesser satisfaction with care after knee or hip replacement among Black patients

A study presented today at the American Academy of Orthopaedic Surgeons 2022 Annual Meeting found that Black patients were less likely than white patients to be completely satisfied with the process of care following knee or hip replacement.

22 Mar 2022

Men presented more severe carpal tunnel syndrome and were offered surgery more often than women

Males presented with more severe carpal tunnel syndrome and were offered surgery more often than females with the condition, according to work by researchers at Hospital for Special Surgery featured today in a poster presentation at the American Academy of Orthopaedic Surgeons 2022 Annual Meeting.

22 Mar 2022

Study provides attainable goals for return to sports after reconstructive foot surgery

Many patients who undergo surgery to correct a collapsing foot share the question: Will I be able to get back to doing the things I love?

22 Mar 2022

A psychedelic drug plus psychotherapy could help improve PTSD symptoms

Post-traumatic stress disorder (PTSD) affects millions of people each year, mostly survivors and witnesses of terrifying or shocking events, such as warfare, assaults or disasters. Because existing treatments don't work for everyone, new therapies are urgently needed.

22 Mar 2022

The effect of SARS-CoV-2 on the expression of CD48 in the lungs and in the peripheral blood of COVID-19 patients

Researchers performed an in situ analysis to evaluate the correlation between CD48 expression and COVID-19.

22 Mar 2022

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Researchers evaluated the importance of the Ex3Lx6L motif in SARS-CoV-2 entry into host cells mediated by the spike protein syncytium formation and membrane fusion.

22 Mar 2022

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Researchers reported a hybrid approach comprising computational models and high throughput screening to discover allosteric ACE2 binders inhibiting viral replication without interrupting ACE2 renal, pulmonary, immune, and cardiovascular functions.

22 Mar 2022

Study: Ketogenic diet helps kill pancreatic cancer cells when combined with a triple-drug therapy

The findings of a new study suggest that a ketogenic diet - which is low in carbohydrates and protein, but high in fat - helps to kill pancreatic cancer cells when combined with a triple-drug therapy developed by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope.

22 Mar 2022

Therapeutics News and Research

Breathlessness and fatigue most common in self reported long-COVID

New therapy makes immunologically 'cold' tumors hot enough for immune attack

Scientists develop first drug to treat uncontrolled secretion of mucins in the airways

Researcher wins three NIH grants to tackle mosquito-borne viruses

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Investigators create specialized, tissue-like structures to model barrier tissues

Importance of Numb-associated kinases in SARS-CoV-2 infection

Study reveals differences in SARS-CoV-2 and SARS-CoV-1 spike protein conformational changes

Comparing outcomes of modern cementless knee implant with standard knee replacement surgery

Study finds lesser satisfaction with care after knee or hip replacement among Black patients

Men presented more severe carpal tunnel syndrome and were offered surgery more often than women

Study provides attainable goals for return to sports after reconstructive foot surgery

A psychedelic drug plus psychotherapy could help improve PTSD symptoms

The effect of SARS-CoV-2 on the expression of CD48 in the lungs and in the peripheral blood of COVID-19 patients

Posaconazole found to be effective as a small molecule fusion inhibitor against SARS-CoV-2 variants

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Study: Ketogenic diet helps kill pancreatic cancer cells when combined with a triple-drug therapy

Is COVID-19 on the verge of ending?

Research reveals enzyme-driven process that activates anti-cancer molecule

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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