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FDA approved Rexulti to be the first antipsychotic for treating agitation in elderly patients with dementia

In trials, the antipsychotic drug brexpiprazole (Rexulti) failed to provide a clinically meaningful benefit and increased the risk of death. Yet the US Food and Drug Administration (FDA) has fast tracked its approval, making Rexulti the first antipsychotic for treating agitation in elderly patients with dementia.

18 Aug 2023

New drug candidate nearly doubles survival for patients with aggressive childhood brain tumors

For the first time, researchers have found a potential drug candidate that improved outcomes for patients with a type of childhood brain tumor for which there are no effective treatments.

17 Aug 2023

Metabolic changes after gastric bypass surgery reverse within one year

A new study from Lund University in Sweden raises questions about the efficacy of bariatric operations involving gastric bypass.

17 Aug 2023

Current methods overestimate malaria parasite multiplication rates

Current methods can vastly overestimate the rates that malaria parasites are multiplying in an infected person's blood, which has important implications for determining how harmful they could be to a host, according to a new report.

17 Aug 2023

Levonorgestrel-piroxicam co-treatment shows promise as more effective emergency contraception

Taking piroxicam, an anti-inflammatory medication commonly used for arthritis pain, at the same time as the levonorgestrel emergency contraceptive pill after unprotected sex prevents significantly more pregnancies compared to taking levonorgestrel alone, according to a randomised controlled trial published in The Lancet.

17 Aug 2023

New study offers preliminary estimates of mortality risk by stage in Alzheimer's disease

Researchers examine the expected survival of people at each stage of Alzheimer's disease.

17 Aug 2023

Can machine learning algorithms identify patients at risk of a delay in starting cancer treatment?

Multi-level machine learning models for estimating the risk of delay between cancer diagnosis and treatment initiation in a large group of cancer patients.

17 Aug 2023

Does depression in caregivers affect the prognosis of Parkinson’s disease patients?

Researchers assessed the relationship between care providers with depressive symptoms and the quality of life, hospital admissions, and emergency department consultations of Parkinson’s disease patients.

17 Aug 2023

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Researchers report that convalescent plasma treatment is most effective in treating hospitalized COVID-19 patients.

17 Aug 2023

Only a small percentage of older adults with early Alzheimer's eligible for new treatments

Only a small percentage of older adults who are in the early stages of Alzheimer's disease meet the eligibility criteria to receive new monoclonal antibody treatments, drugs that target amyloid-ß plaques in the brain, an early sign of Alzheimer's disease.

16 Aug 2023

Wristbands can harbor harmful bacteria, study finds

The COVID-19 pandemic took disinfecting to new heights. Now, a new study examining a commonly used item might convince you not to let your guard down just yet.

16 Aug 2023

Bioengineered nanovesicles could improve cancer treatment

Nanovesicles can be bioengineered to target cancer cells and deliver treatments directly, according to research at Binghamton University, State University of New York.

16 Aug 2023

New review looks at the impact of robotic exoskeletons on recovery of ambulation among individuals with acquired brain injury

A team of New Jersey researchers reviewed the evidence for the impact of robotic exoskeleton devices on recovery of ambulation among individuals with acquired brain injury, laying out a systematic framework for the evaluation of such devices that is needed for rigorous research studies.

16 Aug 2023

Study explores the challenges of the clinical diagnoses of acute exacerbation of chronic obstructive pulmonary disease

A recent study evaluated the clinical, laboratory, and radiographic characteristics of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

16 Aug 2023

CovARC: a streamlined, scalable and accurate COVID-19 risk calculation system

A gamified tool to estimate infection risks associated with day-to-day activities during the COVID-19 pandemic.

16 Aug 2023

Kessler Foundation researchers receive $1.7 million in grants to improve lives of TBI patients

Kessler Foundation scientists received four grants from the New Jersey Commission on Brain Injury Research, totaling nearly $1.7 million for studies based on a variety of novel approaches aimed at improving the lives of individuals with traumatic brain injury (TBI).

15 Aug 2023

Efficacy News and Research

FDA approved Rexulti to be the first antipsychotic for treating agitation in elderly patients with dementia

New drug candidate nearly doubles survival for patients with aggressive childhood brain tumors

Metabolic changes after gastric bypass surgery reverse within one year

Current methods overestimate malaria parasite multiplication rates

Levonorgestrel-piroxicam co-treatment shows promise as more effective emergency contraception

New study offers preliminary estimates of mortality risk by stage in Alzheimer's disease

Can machine learning algorithms identify patients at risk of a delay in starting cancer treatment?

Does depression in caregivers affect the prognosis of Parkinson’s disease patients?

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Only a small percentage of older adults with early Alzheimer's eligible for new treatments

Wristbands can harbor harmful bacteria, study finds

Bioengineered nanovesicles could improve cancer treatment

New review looks at the impact of robotic exoskeletons on recovery of ambulation among individuals with acquired brain injury

Study explores the challenges of the clinical diagnoses of acute exacerbation of chronic obstructive pulmonary disease

CovARC: a streamlined, scalable and accurate COVID-19 risk calculation system

Kessler Foundation researchers receive $1.7 million in grants to improve lives of TBI patients

Epigenetic manipulation may improve breast cancer treatment responses

Researchers develop platform allowing mass-scale production of SARS-CoV-2 mRNA lipid nanoparticle vaccines

Human challenge trials: A game-changer in vaccine development? Examining their role in shaping the pandemic response

Genetic determinants of retinol circulation and their impact on health

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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