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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Avasimibe inhibits SARS-CoV-2 and boosts T-cell responses

Researchers demonstrate that avasimibe-mediated inhibition of ACAT blocks the entry and fusion of SARS-CoV-2 in different cell types.

18 Apr 2022

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

15 Apr 2022

Role of cGAS-STING in SARS-CoV-2 infection

A new study analyzes the activation of cGAS and STING can induce a type I IFN response due to SARS-CoV-2 infection.

15 Apr 2022

Effects of COVID-19 treatment best with combination therapy

There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

15 Apr 2022

Scientists discover differences in interaction of T-cells within tumor microenvironments

A team led by Northwestern Medicine investigators has discovered differences in the distribution and interaction of T-cells within the microenvironment of different regions of both brain tumors and brain metastases, according to findings published in the journal JCI Insight.

14 Apr 2022

Booster dose of mRNA vaccine highly effective in preventing SARS-CoV-2 infection

A booster dose of mRNA vaccine significantly decreases the risk of being infected with either the delta or omicron COVID-19 variants, according to scientists at the Rocky Mountain Center for Occupational and Environmental Health (RMCOEH), a program partnership between the University of Utah and Weber State University.

14 Apr 2022

Exploring strategies for successful delivery of messenger RNA therapeutics

Researchers reviewed the material properties and administration routes that could successfully deliver a messenger ribonucleic acid therapeutic agent to its targeted site.

14 Apr 2022

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

A new study investigated whether APOBEC proteins can directly edit the RNA sequence of SARS-CoV-2 to generate C-to-U mutations.

14 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Study reveals natural infection of pangolins with human RSV

A new study aimed to determine whether humans were able to transmit RSV to Malayan pangolins.

13 Apr 2022

Dietary influences on long COVID in children

A new study discusses possible mechanisms of long COVID in children and how they might relate to their dietary intake of important vitamins and elements.

13 Apr 2022

Quantum computing to predict RNA secondary structures

Researchers investigate the possibility of using quantum computing to create methods that can more effectively and rapidly solve these structures.

13 Apr 2022

People with COVID-19 can shed viral RNA in their feces months after initial infection

The extended presence of viral RNA in feces, but not respiratory samples, along with the association of fecal viral RNA shedding with GI symptoms suggest that SARS-CoV-2 infects the GI tract, and that this infection can be prolonged in a subset of individuals with COVID-19.

13 Apr 2022

Additional booster doses of COVID-19 vaccine help protect solid organ transplant recipients

Additional booster doses of vaccine against COVID-19 are particularly important for those who are immunosuppressed, namely those who have had solid organ transplants, a new study shows.

13 Apr 2022

Regulation of alternative splicing goes haywire in cells of a newly formed embryo

Alternative splicing is a fundamental biological process that allows cells to make many different types of mRNAs and proteins from a limited number of genes. For many animals, including humans, it is a feature that is essential for the development of complex cells such as muscles or neurons.

13 Apr 2022

Case of probable transmission of tick-borne encephalitis virus from an unvaccinated mother to an infant through breast-feeding

A recent study discusses a case report of the probable vertical transmission of tick-borne encephalitis virus (TBEV) from an unvaccinated mother to her newborn via breast milk.

13 Apr 2022

Epigenetics likely to be the reason why lung cancer patients develop treatment resistance

Doctors typically treat people with nonsmall cell lung cancer, a prevalent and typically incurable type of cancer that makes up 80%-85% of lung cancers, with tyrosine kinase inhibitors, specifically epidermal growth factor receptor inhibitors.

13 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

Zika virus can mutate to become more infective and dangerous, finds study

LA JOLLA, CA - Researchers at La Jolla Institute for Immunology (LJI) have found that Zika virus can mutate to become more infective - and potentially break through pre-existing immunity.

13 Apr 2022

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022

RNA News and Research

Further Reading

Avasimibe inhibits SARS-CoV-2 and boosts T-cell responses

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Role of cGAS-STING in SARS-CoV-2 infection

Effects of COVID-19 treatment best with combination therapy

Scientists discover differences in interaction of T-cells within tumor microenvironments

Booster dose of mRNA vaccine highly effective in preventing SARS-CoV-2 infection

Exploring strategies for successful delivery of messenger RNA therapeutics

Study explores role of APOBEC-mediated RNA editing in SARS-CoV-2 fitness

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Study reveals natural infection of pangolins with human RSV

Dietary influences on long COVID in children

Quantum computing to predict RNA secondary structures

People with COVID-19 can shed viral RNA in their feces months after initial infection

Additional booster doses of COVID-19 vaccine help protect solid organ transplant recipients

Regulation of alternative splicing goes haywire in cells of a newly formed embryo

Case of probable transmission of tick-borne encephalitis virus from an unvaccinated mother to an infant through breast-feeding

Epigenetics likely to be the reason why lung cancer patients develop treatment resistance

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Zika virus can mutate to become more infective and dangerous, finds study

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

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