Preclinical News and Research

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CHLA researcher receives $3.7 million NIH grant to study development of neural circuits

Pat Levitt, PhD, Chief Scientific Officer at Children's Hospital Los Angeles and Simms/Mann Chair in Developmental Neurogenetics, received a $3.7M grant from the National Institute of Mental Health to study development of neural circuits.

17 May 2019

University of Virginia chemist identifies potential addiction-free pain reliever

An estimated 1.7 million Americans suffer from substance abuse disorders related to opioid use for pain relief, according to the National Institute on Drug Abuse.

17 May 2019

Scientists unravel how intelligent neural network predicts the functions of proteins

Intelligent virtual companions like Alexa, Siri, and Google Assistant have long become integrated into our everyday lives. And intelligent computational programs, so-called algorithms, have also evolved as an integral tool in scientific research.

16 May 2019

Brain changes related to Alzheimer’s occur years before the onset of clinical symptoms

In a records review of 290 people at risk for Alzheimer's disease, scientists at Johns Hopkins say they have identified an average level of biological and anatomical brain changes linked to Alzheimer's disease that occur three to 10 years -- some even more than 30 years -- before the disease's first recognizable symptoms appear.

From Johns Hopkins Medicine 15 May 2019

Reviews provide overview of advances in the knowledge of focal and sclerotic bone diseases

Recently, extraordinary progress has been made in our understanding of the mechanisms and molecular pathways underlying focal and sclerotic bone diseases, rare disorders which have a strong genetic component.

13 May 2019

CUIMC selects MILabs for upgrades to its molecular imaging capabilities

The MILabs VECTor (OI/CT) system has been acquired by the Department of Radiology at Columbia University Irving Medical Center to upgrade its molecular imaging capabilities.

13 May 2019

Slow-release HIV vaccine shows promise in preclinical trials

A new slow-release vaccine has been shown to boost the immune system’s response to the HIV virus. The vaccine is given in small doses over a period of days, compared to one large dose.

10 May 2019

New drug targeting genetic weakness could become first treatment for childhood brain cancer

A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease.

9 May 2019

Unexpected role of junk RNA in cancer opens new way for treatment of the disease

In an article just published by Trends in Cancer online, Dr. Alan Herbert, founder at InsideOutBio, highlights how the way cancer cells solve the problem of junk RNA makes them vulnerable to a new type of cancer therapy.

7 May 2019

Research in preclinical models suggests promising anti-HIV-1 vaginal microbicide

A vaginal microbicide that could prevent sexual transmission of HIV-1 in women has tremendous potential for saving lives and helping staunch an epidemic.

7 May 2019

Research into cancer signaling network reveals new roadmap to tumor control

In this advanced age of molecular sleuthing, a research team led by Georgetown Lombardi Comprehensive Cancer Center have findings that suggest tumors will eventually become resistant to drug inhibitors of a common cancer pathway (dubbed YAP/TAZ), now in preclinical development.

7 May 2019

NIH-funded trial demonstrates safety of potential treatment in lung transplant patients

A new study, presented today at the American Association for Thoracic Surgery's 99th Annual Meeting, shows that a potential treatment for ischemia- reperfusion injury is safe for humans.

6 May 2019

Less-invasive surgery for lung cancer reduces risk of post-operative bleeding, complications

In a large international clinical study presented at the 99th Annual Meeting of the American Association for Thoracic Surgery, Dr. Moishe Liberman, a thoracic surgeon and researcher at the University of Montreal Hospital Research Center, and his team showed that thoracoscopic lobectomy—video-assisted thoracoscopic surgery—combined with pulmonary artery sealing using an ultrasonic energy device reduced the risk of post-operative bleeding, complications and pain.

6 May 2019

Organ-on-chip systems offered to Asia-Pacific regions by Sydney's AXT

Organ-on-Chip specialist CN Bio has signed a distribution agreement with Sydney-based AXT Pty. Ltd., Australia’s leading supplier of high technology scientific equipment. The agreement will see AXT distribute CN Bio’s innovative bioengineering products to medical researchers in academia and industry throughout Australia, New Zealand and the South Pacific region.

From AXT Pty Ltd 2 May 2019

Diabetes drug could help with smoking cessation

Phillip Robinson has gone from 10 cigarettes a day to one or two every other day after enrolling in a smoking cessation clinical trial launched by researchers at The University of Texas Health Science Center at Houston

30 Apr 2019

Angiotensin receptor blockers could improve response to cancer immunotherapy

A research team led by investigators at Massachusetts General Hospital and the Massachusetts Institute of Technology has found that combining a specialized version of an antihypertension drug with immune checkpoint blockers could increase the effectiveness of cancer immunotherapies.

30 Apr 2019

Prior radioprotection via EGLN inhibitor improves survival in mouse model of pancreatic cancer

Administration of the EGLN inhibitor FG-4592 prior to ablative radiotherapy provided protection against fatal gastrointestinal bleeding and improved survival in a mouse model of unresectable pancreatic cancer.

30 Apr 2019

Role of dentists in identifying domestic violence victims

The University of Arizona College of Medicine - Phoenix and Midwestern University have published an article to bring to light the important role dentists can play in identifying domestic violence victims.

26 Apr 2019

MR Solutions wins third Queen’s Award

MR Solutions, of Guildford has achieved a third Queen’s Award. This follows their win in 2016 with the Queen’s Award for Enterprise, while in 2017 the company was recognized for their excellent performance in International Trade. MR Solutions is a world leader in preclinical imaging solutions involving MRI, PET, SPECT, and CT.

From MR Solutions 25 Apr 2019

Researchers uncover potential clue to halt destruction of nerve cells in people with ALS

A special focus on rogue proteins may hold future promise in stopping the progression of nerve cell destruction in people who have amyotrophic lateral sclerosis or frontotemporal dementia.

24 Apr 2019

Preclinical News and Research

CHLA researcher receives $3.7 million NIH grant to study development of neural circuits

University of Virginia chemist identifies potential addiction-free pain reliever

Scientists unravel how intelligent neural network predicts the functions of proteins

Brain changes related to Alzheimer’s occur years before the onset of clinical symptoms

Reviews provide overview of advances in the knowledge of focal and sclerotic bone diseases

CUIMC selects MILabs for upgrades to its molecular imaging capabilities

Slow-release HIV vaccine shows promise in preclinical trials

New drug targeting genetic weakness could become first treatment for childhood brain cancer

Unexpected role of junk RNA in cancer opens new way for treatment of the disease

Research in preclinical models suggests promising anti-HIV-1 vaginal microbicide

Research into cancer signaling network reveals new roadmap to tumor control

NIH-funded trial demonstrates safety of potential treatment in lung transplant patients

Less-invasive surgery for lung cancer reduces risk of post-operative bleeding, complications

Organ-on-chip systems offered to Asia-Pacific regions by Sydney's AXT

Diabetes drug could help with smoking cessation

Angiotensin receptor blockers could improve response to cancer immunotherapy

Prior radioprotection via EGLN inhibitor improves survival in mouse model of pancreatic cancer

Role of dentists in identifying domestic violence victims

MR Solutions wins third Queen’s Award

Researchers uncover potential clue to halt destruction of nerve cells in people with ALS

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