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Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

There is currently no effective treatment for facioscapulohumeral muscular dystrophy (FSHD), one of the most common neuromuscular diseases, which is caused by an abnormal expression of the transcription factor DUX4.

15 Feb 2022

Novel glycation patterns help understand Omicron immune escape

A new study explores changes in the sugar structure of the SARS-CoV-2 Omicron variant, which may shed light on its immunologic escape and transmissibility characteristics.

15 Feb 2022

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Researchers suggest that extracellular vimentin may act as a coreceptor to allow for SARS-CoV-2 entry into cells.

14 Feb 2022

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

14 Feb 2022

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

14 Feb 2022

Research lays the foundation for developing obesity drugs based on enhancing β-AR signaling

Following up on a 2018 study that identified an epigenetic modifier known as histone deacetylase 11 (HDAC11) as a potential therapeutic target for treating obesity and diabetes, researchers from the University of Colorado School of Medicine have published new research that finds HDAC11 regulates G protein-coupled receptors (GPCRs) called beta-adrenergic receptors (β-ARs).

14 Feb 2022

Progression of Alzheimer's disease is linked to oxidative brain damage, research confirms

Increased oxidative damage is linked to neurodegenerative disorders such as Alzheimer's disease (AD). Even though the pathophysiology of AD has been widely investigated, the likely relationship between mitochondrial dysfunction and the disease remains largely unknown.

14 Feb 2022

Researchers identify a powerful combination of antivirals to treat COVID-19

Researchers at the University of Maryland School of Medicine and University of Pennsylvania Perelman School of Medicine have identified a powerful combination of antivirals to treat COVID-19.

14 Feb 2022

Study shows expression of viral proteases may be used to quantitate SARS-CoV-2 infected cells

A new study describes a new method to quantify SARS-CoV-2 infection, which is much simpler and faster compared to existing methods.

14 Feb 2022

What does the Future of Artificial Intelligence Look Like within the Life Sciences?

In this interview, we speak to Toby Blackburn, the head of Business Development and Strategy at Emerald Cloud Lab, about the future of AI within the life science industry.

From Society for Laboratory Automation and Screening (SLAS) 14 Feb 2022

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., recently received a four-year grant from the National Heart, Lung, and Blood Institute to investigate solutions to help doctors to fight complications after pediatric bone marrow transplantation (BMT).

12 Feb 2022

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

A study in mice - led by researchers at Washington University School of Medicine in St. Louis - shows that a new class of compounds the scientists developed can improve multiple aspects of metabolic syndrome.

12 Feb 2022

Molecular cage helps researchers to get atomic-level details of key cancer protein

Acute myeloid leukemia (AML), the American Cancer Institute estimates, will affect more than 20,000 Americans this year and kill more than 11,000 of them.

11 Feb 2022

First unbiased proteome scale study expands the number of known transcriptional activators

Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. Yet little is known about these proteins, and it wasn't clear how many activators there might be in human cells – until now.

11 Feb 2022

New tools may better help in prevention of heart disease in individuals with chronic kidney disease

A new study reveals that certain changes to models that predict the risk of developing cardiovascular problems in the general population can help clinicians improve risk prediction in individuals with kidney disease.

11 Feb 2022

Showcasing STEM Women in Medical Science

Every year, the UN celebrates the International Day of Women and Girls in Science. For 2022, the focus is placed on recognizing the role women and girls play in STEM as beneficiaries and as agents of change.

11 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Neutralizing antibody ABP-310 found to be highly potent against SARS-CoV-2 variants including Omicron

In a new study, a team of researchers described the efficacy of ABP-310, a neutralizing antibody, against SARS-CoV-2 variants, including Omicron.

10 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

In two recent studies, researchers at Washington University School of Medicine in St. Louis found evidence that the omicron variant of the virus that causes COVID-19 causes less severe disease than previous variants — at least in rodents — but that many antibody-based therapies may not be effective against it.

10 Feb 2022

Therapeutics News and Research

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

Novel glycation patterns help understand Omicron immune escape

Structural protein vimentin facilitates SARS-CoV-2 entry into endothelial cells

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Research lays the foundation for developing obesity drugs based on enhancing β-AR signaling

Progression of Alzheimer's disease is linked to oxidative brain damage, research confirms

Researchers identify a powerful combination of antivirals to treat COVID-19

Study shows expression of viral proteases may be used to quantitate SARS-CoV-2 infected cells

What does the Future of Artificial Intelligence Look Like within the Life Sciences?

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

Molecular cage helps researchers to get atomic-level details of key cancer protein

First unbiased proteome scale study expands the number of known transcriptional activators

New tools may better help in prevention of heart disease in individuals with chronic kidney disease

Showcasing STEM Women in Medical Science

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Neutralizing antibody ABP-310 found to be highly potent against SARS-CoV-2 variants including Omicron

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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