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Researchers discover gene that impacts the development of Ewing sarcoma in children

Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children.

1 Jun 2021

NUS researchers develop a way to automate the production of pharmaceutical small molecules

The discovery and development of new small-molecule compounds for therapeutic use involves a huge investment of time, effort and resources.

1 Jun 2021

Scientists explain possible causes of anaphylaxis following mRNA COVID-19 vaccination

New research from a team of scientists at the Centre for Research in Molecular Modeling, Department of Chemistry and Biochemistry, Concordia University in Canada, has aimed to determine the potential causes of anaphylaxis or allergic reactions reported in some individuals after receiving COVID-19 vaccines, including the mRNA vaccines by Pfizer-BioNTech and Moderna.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

UTokyo researchers study worms to understand the neuroplasticity of learning

As anyone who has ever procrastinated knows, remembering that you need to do something and acting on that knowledge are two different things. To understand how learning changes nerve cells and leads to different behaviors, researchers studied the much simpler nervous system of worms.

1 Jun 2021

A novel multiplexed diagnostic approach for COVID-19

Researchers developed a platform for detecting the virus directly from a patient's sample as well as the immune response through antibodies such as IgG and IgM.

31 May 2021

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 has a single-stranded RNA genome encoding both structural and non-structural proteins. Of these, the latter is known to play a variety of roles in viral replication and the assembly of new viral particles, as well as in suppressing cellular immune responses. A new study reports the activity of one such protein, the non-structural protein 14 (NSP14), which activates the inflammatory mediator NF-κB to trigger intense inflammation.

31 May 2021

Inflammatory brain injury higher in men with acute COVID-19, finds study

The COVID-19 pandemic has been associated with both short- and long-term neurologic complications, including stroke, brain fog and persistent tiredness. A new study concludes that the effects of SARS-CoV-2 on the central nervous system (CNS) are due to the endothelial injury and inflammation that this produces in the brain.

31 May 2021

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

The study, published in the journal Phytomedicine, characterized an active compound, corilagin (a derivative from Phyllanthus urinaria), as potential SARS-CoV-2 entry inhibitors for its preventive application in daily antiviral hygiene products.

31 May 2021

Researchers identify defensins as potential anti-SARS-CoV-2 agents

A recent study conducted at the Ohio State University, USA, and the Fudan University, China, has revealed that alpha-defensin human neutrophil peptide 1 (HNP1), a cationic antimicrobial peptide, can prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from infecting cells by destabilizing the viral spike protein and disrupting spike-mediated viral envelop – host cell membrane fusion.

31 May 2021

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

While DNA is often idealized as the "molecule of life", it is also a highly sophisticated polymer that can be used for next-generation materials. Beyond the fact that it can store information, further fascinating aspects of DNA are its geometric and topological properties, such as knotting and super-coiling.

31 May 2021

Chemists use new technique to manufacture pharmaceutical cholesterol from plant-based materials

Chemists at Otto von Guericke University Magdeburg have, in collaboration with colleagues from CordenPharma, succeeded for the first time in manufacturing pharmaceutical cholesterol from plant-based materials using a highly-effective technique.

29 May 2021

New drug effectively prevents severe COVID-19 in mice infected with SARS-CoV-2

The drug diABZI which activates the body's innate immune response -- was highly effective in preventing severe COVID-19 in mice that were infected with SARS-CoV-2, according to scientists in the Perelman School of Medicine at the University of Pennsylvania

29 May 2021

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

A new study, published in Nano Letters, describes an effective new COVID-19 vaccine candidate based on a messenger ribonucleic acid (mRNA) platform.

28 May 2021

Glycosylation a significant element in SARS-CoV-2 infection and vaccine design, says study

A new study by researchers from Taiwan and the US suggests that the removal of unnecessary glycans from spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposes highly conserved sequences and opens the door for the development of broadly protective vaccines against the virus and its variants.

28 May 2021

IP6 molecules are key to stabilizing and protecting retroviruses

A newly discovered molecule central to the assembly of HIV may provide valuable insight into the development and function of viruses and how to combat them.

28 May 2021

Aptamer Group collaborates with world-leading pharmaceutical company to evaluate Optimer technology

Aptamer Group today announced that it has signed an agreement with the multinational pharmaceutical and biopharmaceutical company Takeda.

From Aptamer Group 28 May 2021

Study explains why it is difficult to withdraw from certain antidepressants

Researchers at the University of Illinois Chicago are a step closer to discovering why it is so difficult for people to withdraw from some antidepressant medications.

28 May 2021

Lactate has antidepressant effect in mice, shows study

Depression is the leading cause of disability worldwide. Neuroscientists from Synapsy - the Swiss National Centre of Competence in Research into Mental Illness - based at Lausanne University Hospital (CHUV) and Lausanne University (UNIL) have recently demonstrated that lactate, a molecule produced by the body during exercise, has an antidepressant effect in mice.

28 May 2021

Researchers develop chemical probe to fight against antibiotic-resistant bacteria

In the perpetual arms races between bacteria and human-made antibiotics, there is a new tool to give human medicine the edge, in part by revealing bacterial weaknesses and potentially by leading to more targeted or new treatments for bacterial infections.

28 May 2021

Molecule News and Research

Researchers discover gene that impacts the development of Ewing sarcoma in children

NUS researchers develop a way to automate the production of pharmaceutical small molecules

Scientists explain possible causes of anaphylaxis following mRNA COVID-19 vaccination

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

UTokyo researchers study worms to understand the neuroplasticity of learning

A novel multiplexed diagnostic approach for COVID-19

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

Inflammatory brain injury higher in men with acute COVID-19, finds study

Corilagin: could a plant compound used in Chinese herbal medicine help prevent COVID-19?

Researchers identify defensins as potential anti-SARS-CoV-2 agents

Harnessing DNA’s properties to craft “‘topologically tunable” DNA-based materials

Chemists use new technique to manufacture pharmaceutical cholesterol from plant-based materials

New drug effectively prevents severe COVID-19 in mice infected with SARS-CoV-2

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

Glycosylation a significant element in SARS-CoV-2 infection and vaccine design, says study

IP6 molecules are key to stabilizing and protecting retroviruses

Aptamer Group collaborates with world-leading pharmaceutical company to evaluate Optimer technology

Study explains why it is difficult to withdraw from certain antidepressants

Lactate has antidepressant effect in mice, shows study

Researchers develop chemical probe to fight against antibiotic-resistant bacteria

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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