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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

In a paper in the journal Nature, Los Alamos National Laboratory scientists Bette Korber, Hyejin Yoon, Will Fischer and James Theiler, among nearly 130 authors from institutions around the world, describe their groundbreaking collaborative work, "Defining the risk of SARS-CoV-2 variants on immune protection."

1 Apr 2022

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Researchers examined the role of sialic acid-binding immunoglobulin-type lectins-1, a myeloid cell-specific receptor, in facilitating SARS-CoV-2 infection of ACE2-deficient macrophages and its effect on pro-inflammatory cytokine expression.

1 Apr 2022

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

A team of international scientists has recently isolated and characterized pan-coronavirus neutralizing antibodies from individuals with pre-existing immunity against SARS-CoV-2.

1 Apr 2022

TMPRSS2 inhibitor found to be a novel and effective therapeutic option against pan-variant SARS-CoV-2 infections

Researchers assessed the efficacy of TMPRSS2 against SARS-CoV-2 variants of concern Alpha, Beta, Gamma, and Delta, in mice and human lung cells.

1 Apr 2022

No evidence of SARS-CoV-2 in the U.K.'s wild deer population

A new study accepted for publication in the journal Transboundary and Emerging Diseases assesses the potential exposure of U.K. deer to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since studies have shown the spill-over of SARS-CoV-2 infections to the Northern American white-tailed deer. If there is a spill-over, wild deer species can act as reservoirs of SARS-CoV-2 with the possibility of the emergence of new variants.

31 Mar 2022

Therapeutic antibodies against filoviruses including Ebola and Marburg

Researchers discuss the development and structural characterization of therapeutic monoclonal antibodies targeting the surface glycoprotein of filoviruses.

31 Mar 2022

Novaplex real-time PCR assays can reliably, rapidly detect SARS-CoV-2 in patient samples

A new study has found that the Novaplex SARS-CoV-2 Variant I, II, and IV real-time PCR assays (from Seegene Technology) can reliably detect SARS-CoV-2 in patient samples and identify known variants of interest and concern.

31 Mar 2022

Study estimates the comparative abundance of SARS-CoV-2 variants via wastewater monitoring

A recent study estimated the comparative abundance of SARS-CoV-2 variants via wastewater monitoring.

31 Mar 2022

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Researchers examined the unique clusters of monocytes and regulatory T cells in the circulating blood from convalescent COVID-19 patients over a prolonged period after recovery, using scRNA sequencing.

31 Mar 2022

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Researchers designed nanoparticles representing RBDs of the S protein of animal sarbecoviruses and SARS-CoV-2 to evaluate their potential as a pan-sarbecovirus vaccine candidate.

31 Mar 2022

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Researchers evaluated the protection conferred by booster doses of the preclinical version of the Moderna mRNA-1273 vaccine and a SARS-CoV-2 Omicron variant-matched vaccine against Omicron infections in mice.

31 Mar 2022

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

Researchers discuss the use of the isothiocyanate sulforaphane for the treatment of both SARS-CoV-2 and HCoV-OC43 infections.

30 Mar 2022

SARS-CoV-2 and pandemic chilblains

Researchers evaluate the pathophysiological relationship between COVID-19 and pandemic-associated chilblain lesions.

30 Mar 2022

Scientists create a biobank of 87 triple-negative breast cancer organoids

It's the cancer version of "mini me." Cold Spring Harbor Laboratory (CSHL) Professor David Spector, among others, has developed organoids, which are miniature, three-dimensional copies of cancers. Organoids can be derived from cancer or healthy cells.

30 Mar 2022

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Further Reading

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

Study explores molecular mechanisms underlying SARS-CoV-2 infection of macrophages and the induction of pro-inflammatory cytokines

Study identifies a new class of monoclonal antibodies that neutralize both alpha and beta coronaviruses

TMPRSS2 inhibitor found to be a novel and effective therapeutic option against pan-variant SARS-CoV-2 infections

No evidence of SARS-CoV-2 in the U.K.'s wild deer population

Therapeutic antibodies against filoviruses including Ebola and Marburg

Novaplex real-time PCR assays can reliably, rapidly detect SARS-CoV-2 in patient samples

Study estimates the comparative abundance of SARS-CoV-2 variants via wastewater monitoring

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Mosaic-8 RBD-nanoparticles show promise as a vaccine candidate for SARS-CoV-2 and potential sarbecoviruses spillovers

Messenger ribonucleic acid boosters shown to be effective against Omicron infections in mice

Chemical in leafy greens could prevent infections by coronaviruses including SARS-CoV-2

SARS-CoV-2 and pandemic chilblains

Scientists create a biobank of 87 triple-negative breast cancer organoids

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

A summary of SARS-CoV-2 RNA-protein interactome studies

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Antiviral functions of interferon regulatory factors during human coronavirus infection

Study describes the identification of a SARS-CoV-2 variant that escapes detection by antigen tests

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

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