Genetic Engineering News and Research

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New technology to make temporary genetic modifications tested in mosquitoes

Texas A&M AgriLife Research scientists have tested a technology to make temporary genetic modifications in mosquitoes. The modifications self-delete over time.

3 May 2022

Study reveals new approach for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds.

29 Apr 2022

Dual release microparticle system promotes cranial bone defect healing

A new dual delivery system designed to sequentially release BMP2 and IGF1 in microparticles in an injectable hydrogel successfully healed an 8-mm cranial defect in rats.

21 Apr 2022

Scientists identify innovative treatment approach for arterial thromboses

Scientists have shown in an animal model that the CXCL12 messenger could be suitable as a target structure for the treatment of blood-clotting disorders.

21 Apr 2022

Researchers identify brain areas that control the ability to perform complex, sequential movements

In a novel set of experiments with mice trained to do a sequence of movements and "change course" at the spur of the moment, Johns Hopkins scientists report they have identified areas of the animals' brains that interact to control the ability to perform complex, sequential movements, as well as to help the mice rebound when their movements are interrupted without warning.

21 Apr 2022

Study explores microbial genetic engineering approach as a replacement for shark livering for squalene

A new study examined possible genetic engineering approaches that could be utilized to tailor the metabolic processes of yeasts, bacteria, and thraustochytrids to optimize the synthesis of squalene.

21 Apr 2022

Newly discovered immune cell "soldier" could be a good target for immunotherapy

Despite the success of immunotherapy in helping many people with cancer, the majority of patients still do not respond to these treatments. There is need for continued research.

20 Apr 2022

Lab grown, self-renewing muscle stem cells can repair muscle tissue damage in mice

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

20 Apr 2022

New technology enables single-cell sorting based on functional outputs

For nearly 40 years, drugmakers have used genetically engineered cells as tiny drug factories. Such cells can be programmed to secrete compounds that yield drugs used to treat cancer and autoimmune conditions such as arthritis.

20 Apr 2022

Solid bone marrow aspirates may be a promising therapeutic approach for promoting wound healing

A new study compares the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The study, conducted in rabbits, is reported in the peer-reviewed journal Tissue Engineering Part A.

18 Apr 2022

Researchers uncover a key regulator of pregnancy-associated heart growth

Northwestern Medicine scientists have uncovered a key regulator of pregnancy-associated heart growth, according to a recent study published in the Journal of Clinical Investigation.

18 Apr 2022

Exploring strategies for successful delivery of messenger RNA therapeutics

Researchers reviewed the material properties and administration routes that could successfully deliver a messenger ribonucleic acid therapeutic agent to its targeted site.

14 Apr 2022

Mutant mice with a human gene variant exhibits ADHD-like problems

Mutant mice are providing scientists with a new neurobiological framework to understand the brain changes observed in distractible humans who carry a common gene variant whose frequency has been associated with Attention Deficit Hyperactivity Disorder (ADHD).

7 Apr 2022

High-throughput screening assay could identify new prostate cancer drugs

A novel high-throughput screening assay is designed to identify inhibitors of the androgen receptor, which plays a critical role in the progression of prostate cancer.

6 Apr 2022

Researchers create method to track SARS-CoV-2 RBD binding in vivo

Researchers developed a method for tracking the binding of the receptor-binding domain of SARS-CoV-2 in vivo using genetically engineered extracellular vesicles that can migrate to ACE2 expressing cells.

30 Mar 2022

Researchers report progress en route to developing a hypoallergenic cat

Researchers at InBio (formerly Indoor Biotechnologies), a biotech company in Virginia, report progress en route to developing a hypoallergenic cat – or at least treating patients with allergies to the domestic cat – in a new article published online in The CRISPR Journal.

29 Mar 2022

Potential new therapeutic target for pancreatic cancer discovered

Northwestern Medicine investigators have discovered that targeting the G alpha 13 protein in pancreatic tumors promotes tumor growth and progression, according to a study published in Cell Reports.

29 Mar 2022

New compound delivered in a nasal spray effectively treats delta variant infection in mice

Researchers have shown a new compound delivered in a nasal spray is highly effective in preventing and treating COVID-19 caused by the Delta variant in mice.

29 Mar 2022

New insights into SARS-CoV-2 immunity gained from natural infection

Antibody-secreting cells (ASCs) peaked at 3-4 weeks and were still being produced at 3-4 months in patients hospitalized with COVID-19, according to a study published in the peer-reviewed journal Viral Immunology.

25 Mar 2022

Lettuce could protect astronauts from bone density loss in microgravity

Astronauts might one day grow and eat genetically modified plants to ward off disease associated with long spaceflights. Researchers at the University of California, Davis College of Engineering have developed a transgenic, or genetically modified, lettuce producing a drug to protect against bone density loss in microgravity.

22 Mar 2022