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2-bromopalmitate reduces senescence phenotype in human cells by modulating palmitoylation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 16 on August 23, 2024, entitled, "2-Bromopalmitate treatment attenuates senescence phenotype in human adult cells - possible role of palmitoylation."

11 Sep 2024

Brazilian research uncovers how liver nerves regulate glucose production under stress

A study led by Brazilian researchers has produced a detailed description of the morphology of the nerves in the liver and how they control production of glucose when the organism is under stress.

11 Sep 2024

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

The frequency of second primary malignancies (SPMs) arising in cancer survivors following treatment with CAR T-cell therapy was statistically comparable to the frequency of SPMs following other standard-of-care therapies, according to a systematic review and meta-analysis.

11 Sep 2024

Innovative method unlocks potential for drugging undruggable GTPases

Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson's and many other diseases.

11 Sep 2024

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

Researchers examine the association between patient-derived xenograft with recurrence and survival rates in triple negative breast cancer patients.

11 Sep 2024

A promising new therapeutic target for MASLD identified

Using a novel stem cell platform, a team of the Medical University of South Carolina researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver disease known as metabolic dysfunction-associated steatotic liver disease, or MASLD.

11 Sep 2024

New study explores the potential of hormone therapy for opioid recovery

In the midst of America's growing opioid crisis, a much healthier alternative to long-term pain management is emerging - one affectionately known as "the cuddle hormone," or oxytocin.

11 Sep 2024

TAAR1 gene: A new key to mental health

In the complex landscape of mental health research, a new peer-reviewed Viewpoint review sheds light on an underexplored genetic player: the trace amine-associated receptor 1 (TAAR1). Published in Genomic Psychiatry (ISSN: 2997-2388, Genomic Press, New York), this thought-provoking analysis suggests that mutations in the TAAR1 gene may be a crucial piece of the puzzle in understanding and treating neuropsychiatric disorders.

11 Sep 2024

Fibrous scars drive glioblastoma recurrence

A Ludwig Cancer Research study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as radiotherapy, surgery, and immunotherapy.

11 Sep 2024

Air pollution spikes drive unnecessary antibiotic use, fueling resistance

Short-term exposure to air pollution significantly increases antimicrobial use for acute respiratory symptoms, highlighting a potential contributor to antibiotic resistance.

10 Sep 2024

Statins found to be cost-effective and linked to better health outcomes in older adults

Statin treatment is cost-effective and linked to better health outcomes in older people with or without previous cardiovascular disease, although the risk reductions were substantially smaller in the latter, reports a modeling on the lifetime benefits of these drugs among the over-70s, published online in the journal Heart.

10 Sep 2024

Bioactive glasses with gallium show promise for bone cancer treatment

Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer.

10 Sep 2024

GLP-1 receptor agonists show promise in treating substance use disorders

A systematic review reveals that GLP-1 receptor agonists may help reduce certain substance use disorders, but findings are inconsistent due to study variability and patient differences.

9 Sep 2024

First crystal structure of alternative DNA shape from the insulin gene revealed

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team.

9 Sep 2024

New chemical modification reduces off-target effects in siRNA drugs

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases.

9 Sep 2024

Sweden reports drop in skin cancer rates for under 50s

The risk of skin cancer, malignant melanoma, now appears to be decreasing in Sweden - at least in those under 50, according to a new study.

9 Sep 2024

‘What is Reciprocity and why is it integral to One Medicine?’, explained by Founder, Professor Noel Fitzpatrick

One Medicine emphasizes the shared health of humans and animals, aiming to optimize medical outcomes through collaborative research and ethical practices.

9 Sep 2024

Systemic glucocorticoid use doubles risk of developing diabetes

Patients who are being treated with systemic glucocorticoids are more than twice as likely to develop diabetes as those not receiving the treatment, the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) will hear.

9 Sep 2024

New hydrogel system could extend semaglutide dosing to once a month for type 2 diabetes patients

French researchers have developed a new drug delivery system that could cut the dosing schedule for the type 2 diabetes and weight control drug semaglutide to just once a month, according to new research to be presented at this year's annual meeting of The European Association for the Study of Diabetes (EASD), Madrid (9-13 Sept).

9 Sep 2024

Researchers uncover connection between two common diabetes drugs with implications for foot ulcer healing

Research shows elevated metformin in diabetic foot ulcer exudates when combined with insulin, highlighting potential for improved wound healing therapies.

9 Sep 2024

Drugs News and Research

2-bromopalmitate reduces senescence phenotype in human cells by modulating palmitoylation

Brazilian research uncovers how liver nerves regulate glucose production under stress

Study shows CAR T-cell therapy's risk of second primary malignancies comparable to other treatments

Innovative method unlocks potential for drugging undruggable GTPases

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

A promising new therapeutic target for MASLD identified

New study explores the potential of hormone therapy for opioid recovery

TAAR1 gene: A new key to mental health

Fibrous scars drive glioblastoma recurrence

Air pollution spikes drive unnecessary antibiotic use, fueling resistance

Statins found to be cost-effective and linked to better health outcomes in older adults

Bioactive glasses with gallium show promise for bone cancer treatment

GLP-1 receptor agonists show promise in treating substance use disorders

First crystal structure of alternative DNA shape from the insulin gene revealed

New chemical modification reduces off-target effects in siRNA drugs

Sweden reports drop in skin cancer rates for under 50s

‘What is Reciprocity and why is it integral to One Medicine?’, explained by Founder, Professor Noel Fitzpatrick

Systemic glucocorticoid use doubles risk of developing diabetes

New hydrogel system could extend semaglutide dosing to once a month for type 2 diabetes patients

Researchers uncover connection between two common diabetes drugs with implications for foot ulcer healing

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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