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New targets identified for treating glioblastoma through genetic screen

A team led by researchers at the University of Toronto has uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer.

4 Nov 2024

Scientists develop synthetic genes that can build intracellular structures

Researchers from the UCLA Samueli School of Engineering and the University of Rome Tor Vergata in Italy have developed synthetic genes that function like the genes in living cells.

4 Nov 2024

Scientists identify 16 types of nerve cells in human sense of touch

No less than 16 different types of nerve cells have been identified by scientists in a new study on the human sense of touch.

4 Nov 2024

New insights into early Huntington's disease mechanisms

Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

4 Nov 2024

Scientists discover how the keto diet may help some people with multiple sclerosis

Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis.

4 Nov 2024

$1 million grant supports research on groundbreaking therapies for MS

Multiple sclerosis (MS) is a debilitating disease of the brain and spinal cord that impacts millions worldwide.

4 Nov 2024

Researchers develop the first polymer-based therapeutic for Huntington’s disease

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein clumps and enhancing neuronal survival.

4 Nov 2024

Mortality risk higher for those diagnosed with type 2 diabetes at younger ages

Findings indicate younger-onset type 2 diabetes is associated with higher mortality and complications, highlighting the need for focused healthcare strategies.

4 Nov 2024

Space-grown stem cells show promise for accelerating biotherapies

Stem cells grown in microgravity aboard the International Space Station (ISS) have unique qualities that could one day help accelerate new biotherapies and heal complex disease, two Mayo Clinic researchers say.

4 Nov 2024

Noninvasive brain stimulation shows promise for enhancing navigation skills in cognitive impairment

A study on deep brain stimulation reveals its impact on spatial navigation, highlighting potential therapeutic avenues for cognitive deficits in aging.

4 Nov 2024

New study identifies potential treatment for tauopathies using carbonic anhydrase inhibitors

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

4 Nov 2024

Scientists develop first durable human lip cell models in the lab

We use our lips to talk, eat, drink, and breathe; they signal our emotions, health, and aesthetic beauty. It takes a complex structure to perform so many roles, so lip problems can be hard to repair effectively. Basic research is essential to improving these treatments, but until now, models using lip cells - which perform differently to other skin cells - have not been available.

4 Nov 2024

Carbonic anhydrase inhibitors clear tau build-up in zebrafish models of tauopathies

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

4 Nov 2024

Rare neural crest stem cells identified as key drivers of cellular reprogramming

A team led by researchers at the University of Toronto has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other researchers.

3 Nov 2024

Single-cell study identifies pro-metastatic cell subpopulations

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing (scRNA-seq) has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.

3 Nov 2024

Huntington’s disease symptoms reduced by new peptide-polymer therapy

Scientists at Northwestern and Case Western Reserve universities have developed the first polymer-based therapeutic for Huntington's disease, an incurable, debilitating illness that causes nerve cells to break down in the brain.

3 Nov 2024

Researchers achieve accurate EV analysis to detect brain disease

Brain disorders like Parkinson's (PD) or Alzheimer's Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages.

3 Nov 2024

New pathway discovery explains MRSA's high-level antibiotic resistance

Researchers have discovered a new cell division pathway in MRSA that enables high-level resistance to β-lactam antibiotics, marking a critical insight into the persistence of these 'superbugs'.

3 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

NCCN leaders collaborate to enhance cancer care in Vietnam

As part of ongoing work to define and advance high-quality cancer care globally, leaders from the National Comprehensive Cancer Network (NCCN) - an alliance of leading cancer centers in the United States - will be in Vietnam today to collaborate on improving cancer care standards throughout the country.

1 Nov 2024