Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Researchers discover epigenetic mechanism underlying ischemic cardiomyopathy

Researchers at the University of Alabama at Birmingham have shed light on an epigenetic reprogramming mechanism that underlies the development of ischemic cardiomyopathy.

13 Aug 2018

Study yields new insights into why the system needs sleep

Sleep is essential for brain functionality and overall health but understanding how sleep delivers its beneficial effects remains largely unknown. In an article publishing on August 9 in the open access journal PLOS Biology, Shanaz Diessler and Maxime Jan at the University of Lausanne and the SIB Swiss Institute of Bioinformatics (Switzerland), sleep researchers are exploring new and unbiased approaches that can take sleep to a systems level.

10 Aug 2018

Researchers describe underlying mechanisms of congestive heart failure

Congestive heart failure is a terminal disease that affects nearly 6 million Americans. Yet its management is limited to symptomatic treatments because the causal mechanisms of congestive heart failure -- including its most common form, ischemic cardiomyopathy -- are not known.

10 Aug 2018

Study provides snapshot of mechanism behind cancer metastasis for the first time

Metastasis, or the formation of secondary tumors, is a leading contributor to the vast majority of deaths related to cancer.

9 Aug 2018

LSU Health research may lead to a change in worldwide obesity prevention strategy

A team of LSU Health New Orleans researchers has found a lower prevalence of overweight and obesity among youth in Grenada compared to US adolescents.

7 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Study could lead to new diagnostic blood test for Kawasaki disease

For the first time, researchers at University of California San Diego School of Medicine and Imperial College London, with international collaborators, have determined that Kawasaki Disease (KD) can be accurately diagnosed on the basis of the pattern of host gene expression in whole blood. The finding could lead to a diagnostic blood test to distinguish KD from other infectious and inflammatory conditions.

6 Aug 2018

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

Scientists have discovered a new type of cell in the human respiratory tract called the pulmonary ionocyte, and linked it to cystic fibrosis.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Scientists develop novel peptide drug that could potentially stop development of liver cancer

A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer.

2 Aug 2018

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.

2 Aug 2018

Study of neuroprotective microRNAs may lead to new avenues for treating tauopathies

Alzheimer's disease is an increasingly prevalent, neurodegenerative condition that erodes memory and other cognitive functions. Treatments for this complex disease have been elusive, although researchers have previously uncovered its main biological features: amyloid-beta plaques and tau tangles.

2 Aug 2018

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline - or pH - chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

2 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

Researchers discover new, rare type of cell in the human airway

In separate studies published online in Nature on Aug. 1, two independent research teams report the discovery of a new, rare type of cell in the human airway.

2 Aug 2018

Blood samples used to understand repair and regeneration mechanisms of transplanted organs

Researchers at Wake Forest Baptist Medical Center have shown that gene expression analysis of blood samples taken from the recipients of transplanted kidneys can be used to better understand the mechanisms that promote repair and regeneration of the transplanted organs.

1 Aug 2018

Cancer cells proliferate less when their internal pH is lowered, study shows

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

31 Jul 2018