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Researchers test the effects of growth molecules exuded by oral bacteria

The human body is filled with friendly bacteria. However, some of these microorganisms, such as Veillonella parvula, maybe too nice.

6 Jan 2021

Researchers identify natural products with potential to disrupt viral spread

Researchers at Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have broken down the genomic and life history traits of three classes of viruses that have caused endemic and global pandemics in the past and identify natural products - compounds produced in nature - with the potential to disrupt their spread.

5 Jan 2021

Genetic risk score can be used to determine risk of developing prostate cancer

Some racial and ethnic groups suffer relatively more often, and fare worse, from common ailments compared to others. Prostate cancer is one disease where such health disparities occur: risk for the disease is about 75 percent higher, and prostate cancer is more than twice as deadly, in Blacks compared to whites.

4 Jan 2021

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Researchers from The University of Texas MD Anderson Cancer Center who profiled more than 45,000 individual cells from patients with peritoneal carcinomatosis (PC), a specific form of metastatic gastric cancer, defined the extensive cellular heterogeneity and identified two distinct subtypes correlated with patient survival.

4 Jan 2021

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

A new study led by clinician-scientists from the National Cancer Centre Singapore, with collaborators from research institutions worldwide, has found that angiosarcomas have unique genomic and immune profiles which allow them to be classified into three different subtypes.

28 Dec 2020

Polygenic risk scores from multi-population data could improve IBD predictions

Using genetic data from nearly 30,000 people, Mount Sinai researchers have built risk scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis. The study was published in Gastroenterology on December 24.

24 Dec 2020

Study clarifies the effect of aging on hematopoietic stem cells

By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells.

24 Dec 2020

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer.

24 Dec 2020

Researchers discover how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

23 Dec 2020

Researcher discovers seven DNA fingerprints that define cancer risk

Lifestyle, or put another way 'bad habits', is one of the textbook explanations for why some people are at higher risk for cancer.

23 Dec 2020

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

A recent computational study from India implicated a dysregulated vitamin D pathway in the pathobiology of the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and opened the door for experimental validation of these observations.

23 Dec 2020

Genetic analysis reveals novel traits associated with COVID-19 severity

Researchers in the United States have conducted genetic correlation studies revealing novel traits associated with the development of severe coronavirus disease 2019 (COVID-19).

23 Dec 2020

Researchers test effects of full doses of anticoagulants in COVID-19 patients

Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients.

23 Dec 2020

Transcription factors in the brain strongly correlate with the behavior of honey bees

An unusual study that involved bar coding and tracking the behavior of thousands of individual honey bees in six queenless bee hives and analyzing gene expression in their brains offers new insights into how gene regulation contributes to social behavior.

23 Dec 2020

Study shows how specific Salmonella bacteria evolved to cause bloodstream infection

University of Liverpool scientists have exploited the combined power of genomics and epidemiology to understand how a type of Salmonella bacteria evolved to kill hundreds of thousands of immunocompromised people in Africa.

22 Dec 2020

Researchers establish BRIDGES program to synergize diagnostic efforts, patient outcome management

For over 20 years, the Genetics Service at the KK Women's and Children's Hospital (KKH) has been providing clinical care to patients with genetic disorders.

22 Dec 2020

Study highlights the far-reaching effects of mutagenic compounds on human health

In order to survive, flourish and successfully reproduce, organisms rely on a high degree of genetic stability. Mutagenic agents, which can threaten the integrity of the genetic code by causing mutations in DNA, pose a serious risk to human health.

21 Dec 2020

New understanding of physical properties of chromatin may show how genome is encoded and decoded

University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid?

20 Dec 2020

Study identifies biomarker gene signature that indicates potential liver toxicity

When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies.

18 Dec 2020

Rapid no-frills detection of SARS-CoV-2 in saliva with LAMP-Cas13

A new paper that appeared as a preprint on the medRxiv* server in December 2020 describes a nucleic acid test validated on saliva samples.

18 Dec 2020

Genomic News and Research

Researchers test the effects of growth molecules exuded by oral bacteria

Researchers identify natural products with potential to disrupt viral spread

Genetic risk score can be used to determine risk of developing prostate cancer

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Scientists identify distinct sub-types of angiosarcomas to allow for targeted treatment

Polygenic risk scores from multi-population data could improve IBD predictions

Study clarifies the effect of aging on hematopoietic stem cells

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers discover how shattered chromosomes make cancer cells more aggressive

Researcher discovers seven DNA fingerprints that define cancer risk

SARS-CoV-2 infection shown to reduce the expression of vitamin D pathway components

Genetic analysis reveals novel traits associated with COVID-19 severity

Researchers test effects of full doses of anticoagulants in COVID-19 patients

Transcription factors in the brain strongly correlate with the behavior of honey bees

Study shows how specific Salmonella bacteria evolved to cause bloodstream infection

Researchers establish BRIDGES program to synergize diagnostic efforts, patient outcome management

Study highlights the far-reaching effects of mutagenic compounds on human health

New understanding of physical properties of chromatin may show how genome is encoded and decoded

Study identifies biomarker gene signature that indicates potential liver toxicity

Rapid no-frills detection of SARS-CoV-2 in saliva with LAMP-Cas13

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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