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FDA proposes new regulatory framework on artificial intelligence, machine learning technologies

The findings come from a cross-sectional study, published in BMJ Open, of the comments submitted to the US Food and Drug Administration (FDA) 'Proposed Regulatory Framework for Modifications to Artificial Intelligence/Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD)--Discussion Paper and Request for Feedback'.

16 Oct 2020

Study: Combining sound and electrical stimulation of tongue can reduce tinnitus

In the largest clinical trial of its kind, researchers show that combining sound and electrical stimulation of the tongue can significantly reduce tinnitus, commonly described as "ringing in the ears." They also found that therapeutic effects can be sustained for up to 12 months post-treatment.

16 Oct 2020

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

The MITHRAS randomized clinical trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair (TMVR) was not superior to conservative medical treatment with regard to the primary endpoint of change in six-minute walking distance.

16 Oct 2020

REFLECT II clinical trial evaluates safety and efficacy of cerebral embolic deflection filter

The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of the device for the primary hierarchical efficacy endpoint.

16 Oct 2020

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve.

16 Oct 2020

UofSC scientists identify biological triggers that promote quicker nerve regeneration

University of South Carolina scientists are exploring ways to make nerve regeneration happen faster and more successfully.

15 Oct 2020

Researchers seek to stop surprise billing for colonoscopy

Nearly 1 in 8 commercially insured patients nationwide who underwent an elective colonoscopy between 2012 and 2017 performed by an in-network provider received "surprise" bills for out-of-network expenses, often totaling hundreds of dollars or more, new analysis from a team led by a UVA Health doctor shows.

15 Oct 2020

Certain live-attenuated vaccines can prevent severe complications of COVID-19

COVID-19 continues to wreak havoc globally, with over one million deaths to date. Yet what if an existing vaccine could make COVID-19 less deadly? A study just published put the theory to test, with promising results.

15 Oct 2020

Army researchers team up to test alternative ways to measure COVID-19 antibody levels

Researchers with the U.S. Army Futures Command are part of a team that tested alternative ways to measure COVID-19 antibody levels, resulting in a process that is faster, easier and less expensive to use on a large scale.

14 Oct 2020

NIH launches new study to streamline COVID-19 treatments for larger clinical studies

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, today launched a study designed to determine whether certain approved therapies or investigational drugs in late-stage clinical development show promise against COVID-19 and merit advancement into larger clinical trials.

14 Oct 2020

Microstructural brain differences linked to waist circumference and BMI in children

Differences in the microstructure of the nucleus accumbens (NAcc), a region in the brain that plays an important role in processing food and other reward stimuli, predict increases in indicators of obesity in children, according to a study funded by the National Institute on Drug Abuse and nine other institutes, all part of the National Institutes of Health.

13 Oct 2020

Statins may lower cancer risk through a pathway unrelated to cholesterol

Cholesterol-lowering drugs called statins may reduce cancer risk in humans through a pathway unrelated to cholesterol, says a study published today in eLife.

13 Oct 2020

How SARS-CoV-2's spike protein highjacks the host cell trafficking machinery

Researchers at The Medical Research Council Laboratory of Molecular Biology have conducted a study showing how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein interacts with host cell factors in ways that promote the formation of syncytia.

13 Oct 2020

Paternal preconception mental health associated with premature births

Both a mother's and father's mental health are associated with increased risk that their baby will be born premature, a new study has found.

13 Oct 2020

"Reparative" cardiac fibroblasts play key role in maintaining the mechanics of the heart

The researcher of the Faculty of Science of the UMA Adrián Ruiz-Villalba, who is also member of the Andalusian Center for Nanomedicine and Biotechnology (BIONAND) and the Biomedical Research Institute of Malaga (IBIMA), is the first author of an international study that has identified the heart cells in charge of repairing the damage caused to this organ after infarction.

13 Oct 2020

Stem cells that repair broken bones can also generate arthritic bone spurs

The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of the Rheumatic Diseases.

12 Oct 2020

Dynamic map reveals how cells fight microbes and preserve memory for future infections

Researchers have charted the activity of tens of thousands of genes in mouse immune cells over the course of an infection.

12 Oct 2020

CWRU and UH secure $4 million to establish research center focused on lung cancer in East Africa

Researchers with the Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have secured $4 million in funding from the National Institutes of Health (NIH)/National Cancer Institute to establish an HIV-associated Malignancy Research Center (HAMRC) focused on lung cancer in East Africa.

9 Oct 2020

Too little sugar is the cause of perforated bones

Bone marrow cancer is currently an incurable disease that affects about 400 people in Norway every year. Professor Therese Standal at NTNU has now found an important reason for bone destruction in people with this disease.

9 Oct 2020

Researchers participate in nationwide study to discover new forms of diabetes

Indiana University School of Medicine researchers are participating in the Rare and Atypical Diabetes Network (RADIANT), a nationwide study funded by the National Institutes of Health. The study seeks to discover new forms of diabetes, identify their causes, and understand how they differ from more common types of diabetes.

9 Oct 2020

Medical Research News and Research

FDA proposes new regulatory framework on artificial intelligence, machine learning technologies

Study: Combining sound and electrical stimulation of tongue can reduce tinnitus

MITHRAS trial investigates superiority of TMVR-induced iASD over medical therapy

REFLECT II clinical trial evaluates safety and efficacy of cerebral embolic deflection filter

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

UofSC scientists identify biological triggers that promote quicker nerve regeneration

Researchers seek to stop surprise billing for colonoscopy

Certain live-attenuated vaccines can prevent severe complications of COVID-19

Army researchers team up to test alternative ways to measure COVID-19 antibody levels

NIH launches new study to streamline COVID-19 treatments for larger clinical studies

Microstructural brain differences linked to waist circumference and BMI in children

Statins may lower cancer risk through a pathway unrelated to cholesterol

How SARS-CoV-2's spike protein highjacks the host cell trafficking machinery

Paternal preconception mental health associated with premature births

"Reparative" cardiac fibroblasts play key role in maintaining the mechanics of the heart

Stem cells that repair broken bones can also generate arthritic bone spurs

Dynamic map reveals how cells fight microbes and preserve memory for future infections

CWRU and UH secure $4 million to establish research center focused on lung cancer in East Africa

Too little sugar is the cause of perforated bones

Researchers participate in nationwide study to discover new forms of diabetes

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