Ancient East Asian peoples may have adapted to coronavirus-like epidemic up to 25,000 years ago

The current coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted humanity's vulnerability to novel viruses.

Modern human genomes contain evolutionary information tracing back tens of thousands of years. This genetic information helps us identify viruses that had affected ancient people.

A new study by researchers at the University of Adelaide and Australian National University in Australia and the University of Arizona in the US shows that an ancient coronavirus-like epidemic drove the adaptation of East Asian peoples from 25,000 to 5,000 years ago. The findings of their study were made available on the preprint server bioRxiv* in November 2020.

Study background

Over the past two decades, strains of coronaviruses created three major outbreaks with significant human impacts. The first outbreak, the severe acute respiratory syndrome (SARS), occurred in China in 2002. The epidemic infected over 8,000 people and claimed nearly 800 lives.

A couple of years later, the Middle East respiratory syndrome (MERS) affected about 2,400 people and caused over 850 deaths in Saudi Arabia.

The most recent outbreak started in December 2019 in Wuhan City in China. Though less virulent and deadly, the coronavirus disease is far more contagious. The outbreak has caused over 55.76 million people and at least 1.34 million deaths.

With the magnitude of the current pandemic, research efforts have been mounted to develop new vaccines and therapies to curb its impact. Some scientists have focused on determining the factors that underlie the infection's epidemiology.

Past evidence suggests that ancient viral epidemics have occurred regularly in the history of the humanity. However, it remains unclear if this has made a marked contribution to population-level differences in SARS-CoV-2 responses today.

The study

The researchers investigated whether ancient coronavirus epidemics have generated genetic differences within and across modern human populations.

The team investigated if selection signals are enhanced within a set of VIPs specific to the coronavirus. They scanned 26 diverse human populations from five continents to prove strong selection acting on proteins that interact with coronavirus strains (CoV-VIPs).

The team identified 42 CoV-VIPs manifesting a coordinated adaptive response that emerged way back (around 25,000 years ago), equating to 900 generations.

Accordingly, the pattern seen was unique to the ancestors of East Asians. The team also noted that the selection pressure created a robust response across the 42 CoV-VIPs genes.

The researchers explained that the adaptive response is probably the result of a multigenerational coronavirus epidemic.

Timing of selection at CoV-VIPs: The figure shows the distribution of selection start times at CoV-VIPs (pink distribution) compared to the distribution of selection start times at all loci in the genome (blue distribution). Details on how the two distributions are compared by the peak significance test, and how the selection start times are estimated with Relate, are provided in STAR Methods.
Timing of selection at CoV-VIPs: The figure shows the distribution of selection start times at CoV-VIPs (pink distribution) compared to the distribution of selection start times at all loci in the genome (blue distribution). Details on how the two distributions are compared by the peak significance test, and how the selection start times are estimated with Relate, are provided in STAR Methods.

One feature of the adaptive response seen is that selection appears to be continuously happening over 20,000 years. This means that coronavirus pandemics have been occurring throughout history. For instance, in recent years, coronavirus epidemics occurred approximately every decade, suggesting that the pattern may have occurred throughout history in East Asian peoples.

The team concluded that they could infer ancient viral epidemics affecting the ancestors of East Asian populations. This resulted in coordinated adaptive chances across at least 42 genes.

"Our findings highlight the utility of incorporating evolutionary genomic approaches into standard medical research protocols. Indeed, by revealing the identity of our ancient pathogenic foes, evolutionary genomic methods may ultimately improve our ability to predict – and thus prevent – the epidemics of the future," the researchers explained.

Continuously spreading

Understanding how populations respond to the current pandemic can help scientists develop new therapies and vaccines to curb its spread.

So far, there is still no treatment and vaccine available for COVID-19.

In the United States, the total number of cases has topped 11.36 million, with more than 248,00 deaths. Countries such as India and Brazil report over 8.91 million and 5.91 million cases, respectively.

*Important Notice

bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

Source:
Journal reference:
Angela Betsaida B. Laguipo

Written by

Angela Betsaida B. Laguipo

Angela is a nurse by profession and a writer by heart. She graduated with honors (Cum Laude) for her Bachelor of Nursing degree at the University of Baguio, Philippines. She is currently completing her Master's Degree where she specialized in Maternal and Child Nursing and worked as a clinical instructor and educator in the School of Nursing at the University of Baguio.

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