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Novel molecule could offer a new way to fight against SARS coronavirus 2

Scientists at the University of Bonn and the caesar research center have isolated a molecule that might open new avenues in the fight against SARS coronavirus 2. The active ingredient binds to the spike protein that the virus uses to dock to the cells it infects.

27 Mar 2021

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

University of Birmingham researchers are working to isolate and extract the COVID-19 encounter complex in a form that is stable enough for identification of target sites for future anti-viral drugs.

27 Mar 2021

New study uncovers potential therapeutic target for lupus

A recent study published in JCI found that a neutrophil's endoplasmic reticulum, the organelle that normally makes proteins in the cell, becomes stressed in the autoimmune disorder lupus.

26 Mar 2021

Chemists successfully convert flat nitrogen-containing molecules into 3D structures

A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs.

26 Mar 2021

Scientists describe the mechanisms that regulate embryonic stem cells

Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best possible state for their use in regenerative medicine.

26 Mar 2021

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

A University of Arizona Health Sciences researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.

25 Mar 2021

Study identifies NCOA3 as a novel therapeutic target for melanoma

For the first time, activation of nuclear receptor coactivator 3 (NCOA3) has been shown to promote the development of melanoma through regulation of ultraviolet radiation (UVR) sensitivity, cell cycle progression and circumvention of the DNA damage response.

25 Mar 2021

Medical practitioners use octacalcium phosphate to improve bone repair

Bone repair wasn't generally successful until the late 1800s. Until then, there were few options to repair major bone damage. Most materials don't have the functionality of bone and don't support blood vessels growing through them.

25 Mar 2021

Biomaterials can help modulate the immune activity of liver cells

Biomaterials are substances, natural or manmade, that are used in medicine to interact with the human body for various purposes, such as wound healing and tissue regeneration.

25 Mar 2021

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

Despite continued improvements in antibiotics and hospital intensive care, staph sepsis - a bloodstream infection caused by Staphylococcus aureus bacteria - still causes severe illness or death in 20 to 30 percent of patients who contract it.

24 Mar 2021

New method for scDNA sequencing provides insights into breast cancer evolution

vercoming previous technical challenges with single-cell DNA (scDNA) sequencing, a group led by researchers at The University of Texas MD Anderson Cancer Center has developed a novel method for scDNA sequencing at single-molecule resolution.

24 Mar 2021

Auto-aggressive immune cells cause liver immune pathology in non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH), often called 'fatty liver hepatitis', can lead to serious liver damage and liver cancer.

24 Mar 2021

Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

An international team of researchers has found that three commonly used antiviral and antimalarial drugs are effective in vitro at preventing replication of SARS-CoV-2, the virus that causes COVID-19.

24 Mar 2021

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

Acriflavine is traditionally employed as a topical antiseptic, though has more recently been implicated as an antiviral agent at low doses, potentially by stimulating the production of interferon. In a new study recently uploaded to the bioRxiv* preprint server, the application of the drug to SARS-CoV-2 infection is investigated, demonstrating a broad activity towards a range of other betacoronaviruses.

24 Mar 2021

SARS-CoV-2 can cause persistent dendritic cell deficiencies

In a new study, the persistent influence of SARS-CoV-2 on dendritic cell deficiency seven months post-infection is asserted, and the mechanism of action investigated.

24 Mar 2021

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

Researchers have generated protease-activatable fluorescent and luminescent biosensors for SARS-CoV-2 MPro (main protease) and PLPro (papain-like protease) activity, one based on “flip” GFP (FlipGFP), and the other based on circularly permuted firefly luciferase (FFluc).

24 Mar 2021

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

A new study describes the use of a combination of virtual and experimental screening protocols to identify potential inhibitors of the virus, which could lead to rapid drug development.

24 Mar 2021

Study may lead to more refined approaches for head and neck cancers

By targeting an enzyme that plays a key role in head and neck cancer cells, researchers from the UCLA School of Dentistry were able to significantly slow the growth and spread of tumors in mice and enhance the effectiveness of an immunotherapy to which these types of cancers often become resistant.

24 Mar 2021

Checkpoint inhibition could offer an effective treatment option for patients with rare cancer

Peritoneal mesothelioma is cancer that develops in the lining of the abdomen, which is known as the peritoneum.

24 Mar 2021

Gene responsible for cholesterol dysregulation in brain cancer cells could be a target for future drugs

Most people relate cholesterol to heart health, but it is also a critical component in the growth and spread of brain cancer.

23 Mar 2021

Molecule News and Research

Novel molecule could offer a new way to fight against SARS coronavirus 2

Using molecular ‘cookie cutters’ to isolate first ever COVID-19 encounter complex

New study uncovers potential therapeutic target for lupus

Chemists successfully convert flat nitrogen-containing molecules into 3D structures

Scientists describe the mechanisms that regulate embryonic stem cells

UArizona researcher finds a unique approach to tackle both Alzheimer’s disease and diabetes

Study identifies NCOA3 as a novel therapeutic target for melanoma

Medical practitioners use octacalcium phosphate to improve bone repair

Biomaterials can help modulate the immune activity of liver cells

Repurposed heart and flu drugs that protect platelets improve survival of septic mice

New method for scDNA sequencing provides insights into breast cancer evolution

Auto-aggressive immune cells cause liver immune pathology in non-alcoholic steatohepatitis

Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

Researchers examine acriflavine's antiviral potential against SARS-CoV-2

SARS-CoV-2 can cause persistent dendritic cell deficiencies

Researchers develop innovative biosensor that can detect and quantitate SARS-CoV-2 infection

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

Study may lead to more refined approaches for head and neck cancers

Checkpoint inhibition could offer an effective treatment option for patients with rare cancer

Gene responsible for cholesterol dysregulation in brain cancer cells could be a target for future drugs

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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