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Obesity-related metabolic stress may affect brain health far earlier than expected

For decades, scientists have known that what harms the body often harms the brain. Conditions such as obesity, high blood pressure and insulin resistance strain the body's vascular and metabolic systems.

25 Nov 2025

Scientists uncover how brain enzyme OTULIN controls tau expression

Scientists have uncovered a surprising mechanism by which a brain enzyme called OTULIN controls the expression of tau, the protein that forms toxic tangles in Alzheimer's disease.

25 Nov 2025

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to humans.

24 Nov 2025

Black cumin: A promising natural agent with potential against chronic diseases

Black cumin seeds contain diverse secondary metabolites, including thymoquinone, flavonoids, triterpenoids and alkaloids, that demonstrate broad antimicrobial, antioxidant, anti-inflammatory and anticancer activity. Early preclinical and limited clinical evidence shows therapeutic potential across chronic diseases, supported by mechanistic and structure activity relationship findings.

24 Nov 2025

New insights into ribosome collisions and stress response

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

24 Nov 2025

Research explores new solvent strategies to extend shelf life of injectable therapeutics

Sugar-based liquid solvents store crucial injection-based therapeutics such as insulin and vaccines.

22 Nov 2025

New neuron signaling mechanism reveals safer pathway for pain treatment

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead to safer, more effective treatments.

20 Nov 2025

Changes in brain fats play a key role in Alzheimer's development and progression

More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along with the buildup of amyloid-beta (amyloid) plaques and tau protein tangles.

20 Nov 2025

Cancer cells hijack cell death enzyme to regrow after treatment

The emergence of cancer drug resistance remains one of the most pressing problems in cancer care and there is a critical need to devise approaches to mitigate it.

19 Nov 2025

New clinical trial shows promise for shorter TB treatment

New clinical trial results presented by TB Alliance at the Union World Conference on Lung Health show that the novel antibiotic candidate sorfequiline (TBAJ-876), a next-generation diarylquinoline, has the potential to improve tuberculosis (TB) treatment when combined with pretomanid and linezolid in a treatment regimen known as "SPaL."

19 Nov 2025

Blocking mir-21 shows promise for slowing bladder cancer growth

Bladder cancer ranks among the ten most common types of cancer worldwide. The main treatment is bladder removal surgery, and despite advances in systemic therapies, recurrence is frequent in the most aggressive forms of the disease.

18 Nov 2025

Cornell team unveils high-resolution tool for tracking kinase activity

Cornell researchers have developed a powerful new biosensor that reveals, in unprecedented detail, how and where kinases – enzymes that control nearly all cellular processes – turn on and off inside living cells.

13 Nov 2025

Scientists discover hidden weakness in Lyme disease bacterium

For decades, Lyme disease has frustrated both physicians and patients alike. Caused by the corkscrew-shaped bacterium Borrelia burgdorferi, the infection, if left untreated, can linger for months, leading to fever, fatigue and painful inflammation.

13 Nov 2025

Collaborative effort advances next-generation therapies for pancreatic and GI cancers

Last year, researchers at the University of California, Riverside, developed a novel "molecular crowbar" strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors including pancreatic cancer.

12 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Breakthroughs in theranostic nanomaterials for traumatic brain injury management

Traumatic brain injury (TBI) remains one of the most pressing public health challenges, leaving millions with lasting disabilities each year.

12 Nov 2025

Simple blood test may be a better guide treatment for ovarian cancer

More than 300,000 women are diagnosed with ovarian cancer globally each year.

12 Nov 2025

Scientists reveal mathematical law governing limits of biological growth

A research team including a scientist of Earth-Life Science Institute (ELSI) at Institute of Science Tokyo, Japan, has identified a novel principle in biology that mathematically explains why the growth of organisms slows as nutrients become more abundant-a phenomenon known as "the law of diminishing returns."

11 Nov 2025

Study provides insights into the obesity–breast cancer link

Obesity and cancer are two major health challenges of our time, yet the link between them remains only partially understood.

10 Nov 2025

Uppsala researchers develop Trojan horse approach for medulloblastoma treatment

The malignant pediatric brain tumor medulloblastoma is driven by proteins deep within the cancer cells, for which there are often no effective drugs available.

10 Nov 2025