Genomic News and Research

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Time of radiotherapy can influence the effectiveness of cancer treatment

A team of researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER) and the University of Seville, in collaboration with the Virgen Macarena University Hospital, have identified a fundamental mechanism that links the 24-hour circadian cycle to the precise repair of DNA breaks.

30 Jan 2026

How DNA and life experiences leave distinct marks on the human immune system

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and environmental exposures shape the human immune system through distinct DNA methylation mechanisms. Genetic effects concentrate within gene bodies of memory cells, while environmental exposures primarily remodel regulatory regions in naive immune cells.

28 Jan 2026

Zebrafish can play a decisive role in clinical interpretation of spinal muscular atrophy

The tiny zebrafish is helping researchers rapidly determine whether a newborn's genetic mutation is likely to cause spinal muscular atrophy (SMA), one of the leading causes of infant mortality worldwide.

28 Jan 2026

NIH grant advances Indigenous-driven genomic research in Alaska and Oklahoma

A transdisciplinary team led by Southcentral Foundation, a Tribal healthcare organization in Anchorage, Alaska, has been awarded a competitive grant from the National Institutes of Health. Jessica Blanchard, Ph.D., senior research scientist at the University of Oklahoma's Center for Applied Social Research, is a key collaborator on the project, representing the continuation of a longstanding partnership between OU and Southcentral Foundation.

27 Jan 2026

Large multi-ancestry study expands understanding of schizophrenia genetics

A landmark study led by researchers with the Department of Veterans Affairs has uncovered new genetic insights into schizophrenia by analyzing data from ancestrally diverse populations, including African Americans, through the Million Veteran Program (MVP) and Cooperative Studies Program (CSP).

24 Jan 2026

Shared genetic architecture links schizophrenia with hemispheric white matter microstructure

Schizophrenia is a highly heterogeneous psychiatric disorder affecting ~1% of the global population, typically emerging in adolescence or early adulthood and characterized by hallucinations, delusions, disorganized thinking, and cognitive impairments; while its etiology remains elusive, genetic factors are widely recognized as fundamental, and GWAS have identified over 200 genome-wide significant loci.

24 Jan 2026

Genetic study links vitamin B1 metabolism to gut motility and IBS risk

Research links thiamine metabolism to gut motility, identifying genetic markers that could lead to new therapies for IBS and related digestive disorders.

23 Jan 2026

FIU's personalized cancer treatment shows promise

Researchers at FIU are advancing a personalized approach to cancer treatment that is showing increasingly promising results for patients with hard-to-treat disease, supported by new philanthropic investment that is helping expand the science behind the work.

22 Jan 2026

Sperm RNA aging shift that may explain paternal age effects

Study reveals an 'aging cliff' in sperm RNA, linking age-related changes to early development and highlighting risks associated with advanced paternal age.

22 Jan 2026

Large study identifies more than 100 genetic regions linked to schizophrenia

A team of researchers led by scientists from the Icahn School of Medicine at Mount Sinai, SUNY Downstate Health Sciences University, and the Department of Veterans Affairs has conducted the largest and most comprehensive genome-wide association study (GWAS) to date of schizophrenia in individuals of African ancestry.

21 Jan 2026

As US is poised to lose measles-free status, RFK’s new CDC deputy downplays its significance

After a year of ongoing measles outbreaks that have sickened more than 2,400 people, the United States is poised to lose its status as a measles-free country.

21 Jan 2026

Analyzing bacterial enzymes in pikromycin synthesis

Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely used to treat a range of infections, including pneumonia and skin infections.

21 Jan 2026

Using AI to understand the age of disease onset in Huntington's patients

A team from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences at the University of Barcelona (UBneuro) has applied advanced artificial intelligence techniques to better understand why Huntington's disease can begin at very different ages in patients.

20 Jan 2026

The challenge of tracking asymptomatic Mpox

The mpox virus appears to be circulating silently in parts of Nigeria, in many cases without the symptoms typically associated with the disease, according to new research led by scientists from the University of Cambridge and partners in Nigeria. The findings may have implications for controlling the spread of the disease.

20 Jan 2026

How "old RNA" reshapes sperm metabolism

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity and stillbirth. But what drives this increased risk remains unknown.

20 Jan 2026

Genomic screening uncovers hidden cancer and heart disease risk in young adults

A nationwide Australian pilot screened more than 10,000 adults aged 18–40 years for high-risk genetic variants linked to hereditary cancer and familial hypercholesterolaemia, identifying clinically actionable findings in about 2% of participants.

19 Jan 2026

Blood metabolites reveal who will develop type 2 diabetes years before diagnosis

This large prospective study integrated blood metabolomics, genetics, and lifestyle data to identify hundreds of metabolites associated with long-term risk of type 2 diabetes in initially healthy adults. A validated 44-metabolite signature improved risk prediction beyond conventional factors, offering insights into biological pathways and opportunities for earlier, more precise prevention.

18 Jan 2026

Ancient ice and modern pollution combine to spread antibiotic resistance as glaciers melt

Glaciers harbor both ancient and human-derived antibiotic resistance genes, preserved in ice and increasingly mobilized by climate-driven melt. This global review proposes a glacier-to-downstream “continuum” to understand how resistance genes may move through connected freshwater ecosystems.

18 Jan 2026

Researchers discover how Mycoplasma pneumoniae acquires cholesterol from human hosts

A multidisciplinary team has uncovered a key mechanism that allows the human bacterium Mycoplasma pneumoniae-responsible for atypical pneumonia and other respiratory infections-to obtain cholesterol and other essential lipids directly from the human body.

16 Jan 2026

Single-cell technique maps pre-malignant gene mutations in solid tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the first time, in a study led by investigators at Weill Cornell Medicine and the New York Genome Center.

16 Jan 2026