Therapeutics News and Research

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WHO designates Omicron (B.1.1.529) as SARS-CoV-2 Variant of Concern

The Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE) is an independent group of experts that periodically monitors and evaluates the evolution of SARS-CoV-2 and assesses if specific mutations and combinations of mutations alter the behavior of the virus.

26 Nov 2021

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.

25 Nov 2021

Using metal nanoparticles to fight SARS-CoV-2

A recent review article looks at the potential of nanotechnology in fighting severe acute respiratory syndrome 2 (SARS-CoV-2), with several possibilities of strategies in therapeutics, vaccines, and prevention.

25 Nov 2021

Mtb's exotoxin secretion and trafficking mechanism revealed

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.

25 Nov 2021

What may the future hold in terms of SARS-CoV-2 variants?

Researchers fit data on SARS-CoV-2 variants by exploiting a function that depends on the global number of infected cases since the start of the pandemic.

25 Nov 2021

New, improved organoids shed light on untreatable form of prostate cancer

A multi-institutional team of investigators led by bioengineer Ankur Singh has developed research tools that shed new light on a virtually untreatable form of prostate cancer, opening a pathway that may lead to novel therapeutics and a glimmer of hope for patients.

24 Nov 2021

Acute SARS-CoV-2 infection during pregnancy associated with placental ACE2 shedding

A new study, published on the bioRxiv* preprint server, hypothesized that ACE-2 expression and ADAM17 activity in the placenta is affected by the timing of SARS-CoV-2 infection of the mother.

24 Nov 2021

New technique may be a significant leap forward in the understanding of human cells

Most human diseases can be traced to malfunctioning parts of a cell — a tumor is able to grow because a gene wasn't accurately translated into a particular protein or a metabolic disease arises because mitochondria aren't firing properly, for example. But to understand what parts of a cell can go wrong in a disease, scientists first need to have a complete list of parts.

24 Nov 2021

CIRM awards $4.1 million to advance CAR T-cell therapy from the lab to clinic

On November 23, 2021, the California Institute for Regenerative Medicine (CIRM) governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T-cell therapy from the laboratory into the clinic.

24 Nov 2021

How does penicillin work?

In this interview, we spoke to Dr. Bartlomiej Salamaga about his latest research that discovered how penicillin works in the body.

24 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

WHO’s C-TAP and MPP finalize licensing agreement with CSIC for COVID-19 serological antibody technology

WHO's COVID-19 Technology Access Pool and the Medicines Patent Pool today finalized a licensing agreement with the Spanish National Research Council for a COVID-19 serological antibody technology.

23 Nov 2021

Characterization of B-cell receptor repertoires in COVID-19 patients

In a new study published in the journal Human Immunology, scientists sought to better understand how B-cell immune repertoire changes over time during SARS-CoV-2 infection by comprehensively characterizing the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients.

22 Nov 2021

Study identifies key factor sustaining malignant tumor state

In a study published in Nature Cancer, researchers led by Prof. Cedric Blanpain, WELBIO investigator, Director of the Laboratory of Stem Cells and Cancer and Professor at the Université libre de Bruxelles, Belgium, demonstrated that NR2F2 is an essential regulator of malignant tumor state by controlling cancer stem cell and tumor maintenance in mouse and human cancers.

22 Nov 2021

Therapeutics News and Research

WHO designates Omicron (B.1.1.529) as SARS-CoV-2 Variant of Concern

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

Using metal nanoparticles to fight SARS-CoV-2

Mtb's exotoxin secretion and trafficking mechanism revealed

What may the future hold in terms of SARS-CoV-2 variants?

New, improved organoids shed light on untreatable form of prostate cancer

Acute SARS-CoV-2 infection during pregnancy associated with placental ACE2 shedding

New technique may be a significant leap forward in the understanding of human cells

CIRM awards $4.1 million to advance CAR T-cell therapy from the lab to clinic

How does penicillin work?

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

WHO’s C-TAP and MPP finalize licensing agreement with CSIC for COVID-19 serological antibody technology

Characterization of B-cell receptor repertoires in COVID-19 patients

Study identifies key factor sustaining malignant tumor state

Human Proteoform Project aims to define the entire collection of proteins in the body

Naturally occurring phage A1-1 kills dysentery-causing bacteria in sub-Saharan Africa, southern Asia

Human lung airway-on-a-chip faithfully recapitulates cystic fibrosis pathology

Researchers use embryonic stem cell model to study genetic architecture in the hypothalamus

Scientists unravel near-atomic-scale structure of depression-linked brain receptor

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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