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IRF-5 identified as key to preventing immune cell exhaustion

In fighting chronic infections or certain cancers, CD8+ T cells-the immune system's frontline soldiers-eventually become exhausted. They lose effectiveness and respond less efficiently to threats.

24 Jul 2025

Standard DNA tests miss most cases of NUT carcinoma

The diagnosis of a suspected lung, head, and neck cancer called NUT carcinoma should include additional testing capable of detecting gene fusions that are definitive markers of the disease, according to a study by Dana-Farber Cancer Institute investigators.

24 Jul 2025

Different anti-PD-L1 antibodies show varied results in tumor growth inhibition

Immune checkpoint inhibitors (ICIs), a powerful form of immunotherapy, have revolutionized cancer treatment by unleashing the body's own immune system to fight tumors.

24 Jul 2025

AI-driven microscopy predicts and tracks protein aggregation in real time

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's.

24 Jul 2025

Promising therapeutic approach identified for multiple myeloma

Researchers at Uppsala University have identified a promising therapeutic approach for the challenging blood cancer multiple myeloma.

24 Jul 2025

Scientists discover neuron-like communication system in the gut

In a key advance for regenerative medicine and gut health, scientists from Duke-NUS Medical School and Nanyang Technological University, Singapore (NTU Singapore) have uncovered a precise and unexpected communication system in the gut.

24 Jul 2025

Gut bacteria send direct signals to the brain to stop you from overeating

Researchers have discovered a novel gut-brain sensory circuit in mice where specialized colonic cells sense bacterial flagellin and rapidly suppress feeding via the vagus nerve. This "neurobiotic sense" operates independently of immune pathways, revealing a direct neural mechanism for microbiota-host communication.

24 Jul 2025

Reactivating silent genes offers hope for Rett syndrome treatment

Researchers led by UC Davis Health scientist Sanchita Bhatnagar have developed a promising gene therapy that could treat Rett syndrome.

23 Jul 2025

Forever chemicals cross placenta and breast milk affecting babies’ immunity

New research reveals that tiny amounts of PFAS-widely known as "forever chemicals"-cross the placenta and breast milk to alter infants' developing immune systems, potentially leaving lasting imprints on their ability to fight disease.

23 Jul 2025

Blocking key host pathways may stop Cryptosporidium infections

Researchers at the Francis Crick Institute have mapped the human metabolic pathways that Cryptosporidium, an intestinal parasite, requires to survive.

23 Jul 2025

New method genetically blocks mosquitoes from transmitting malaria

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

23 Jul 2025

Neurons shift during repeated navigation of identical paths

In a new study, Northwestern University neurobiologists found the brain's internal GPS changes each time we navigate a familiar, static environment.

23 Jul 2025

Novel DNA plasmid therapy shows high success rate in treating chronic pain in dogs

Elenagen™, a novel DNA plasmid therapy that previously demonstrated high clinical benefit and low toxicity in cancer patients, has now shown significant promise in alleviating chronic pain demonstrating a 90% success rate.

23 Jul 2025

New diagnostic test identifies head and neck cancer patients curable by surgery alone

Researchers developed a diagnostic test based on the LIMA1-alpha protein to distinguish patients with head and neck squamous cell carcinoma who can be cured with surgery alone, without the need for radiation or chemotherapy.

23 Jul 2025

Long-term air pollution exposure triggers allergic immune responses in the lungs

Air pollution is a global health concern, with over 90% of the world's population breathing air that exceeds World Health Organization safety standards.

23 Jul 2025

Everyday diet ingredients like caffeine can affect bacterial antibiotic resistance

Ingredients of our daily diet - including caffeine - can influence the resistance of bacteria to antibiotics. This has been shown in a new study by a team of researchers at the Universities of Tübingen and Würzburg led by Professor Ana Rita Brochado.

23 Jul 2025

Liupao tea improves metabolic syndrome risks in clinical trial

Liupao tea shows promise in improving metabolic syndrome markers, enhancing heart health and gut balance in just three months, according to recent research.

23 Jul 2025

New therapeutic approach targets undruggable protein driving aggressive breast cancer

In a major stride toward tackling aggressive breast cancer, researchers from The Hebrew University of Jerusalem have developed druglike molecules that degrade a previously "undruggable" cancer-driving protein.

23 Jul 2025

Deep-sea bacterial compound triggers pyroptosis to fight cancer

Promoting pyroptosis-an inflammatory form of programmed cell death-has become a promising treatment strategy for cancer.

23 Jul 2025

Probiotic bacteria found to reshape cell behavior in vitro

This study reveals how probiotic bacteria directly influence brain cell function, highlighting gut-brain communication and potential therapeutic applications.

23 Jul 2025