Deep-sea bacterial compound triggers pyroptosis to fight cancer

Promoting pyroptosis-an inflammatory form of programmed cell death-has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain sugar molecule, or exopolysaccharide, from deep-sea bacteria and demonstrated that it triggers pyroptosis to inhibit tumor growth.

The compound, called EPS3.9, consists of mannose and glucose and is produced by the Spongiibacter nanhainus CSC3.9 bacterial strain and other members of the genus Spongiibacter. Mechanistic analyses showed that EPS3.9 can directly target 5 membrane phospholipid molecules and exert tumor toxicity by stimulating pyroptosis in human leukemia cells. EPS3.9 also had significant anti-tumor effects in the mice with liver cancer and activated anti-tumor immune responses.

Our work not only provides a theoretical basis for developing more carbohydrate-based drugs but also highlights the importance of exploring marine microbial resources."

Chaomin Sun, PhD, corresponding author of the Chinese Academy of Sciences