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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Researchers at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA and the David Geffen School of Medicine at UCLA have developed a new mouse model of Huntington's disease that recapitulates more Huntington's disease-like characteristics than earlier models.

2 Feb 2022

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

In a new study, researchers assessed a rapid antigen (Ag) test for SARS-CoV-2.

2 Feb 2022

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

In a new study, researchers demonstrated that a commercial real-time polymerase chain reaction (RT-PCR) assay rapidly detects the SARS-CoV-2 Omicron variant.

2 Feb 2022

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Researchers from China summarized the representative structures of SARS-CoV-2 proteins and discussed the development of novel therapeutic agents for targeting these proteins to treat and prevent COVID-19.

2 Feb 2022

Study reveals pet hamsters can acquire SARS-CoV-2 infection in real-life settings and transmit the virus back to humans

Researchers investigated the transmission of the SARS-CoV-2 Delta VOC from infected hamsters to humans.

2 Feb 2022

Study proposes Omicron variant may be derived from recombination of two early SARS-CoV-2 PANGO lineages

A recent study showed that the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron variant is a chimera of two earlier PANGO lineages of SARS-CoV-2.

2 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

Developing post-vaccination SARS-CoV-2 standard reference sera

A new study reports the generation of reference sera reagents that were obtained from subjects vaccinated with one of four COVID-19 vaccines.

1 Feb 2022

Study: COVID-19 infections tend to be milder in fully vaccinated patients

The clinical and imaging characteristics of COVID-19 breakthrough infections in fully vaccinated patients tend to be milder than those of partially vaccinated or unvaccinated patients, according to a new multicenter study published in the journal Radiology.

1 Feb 2022

Researchers discover why patients suffering with hypertension also have diabetes

The long-standing enigma of why so many patients suffering with high blood pressure (known as hypertension) also have diabetes (high blood sugar) has finally been cracked by an international team led by the universities of Bristol, UK, and Auckland, New Zealand.

1 Feb 2022

New RNA therapies for the treatment of heart failure and organ fibrosis

RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic approaches.

1 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

New blood test quickly detects COVID-19 infection and disease severity

George Washington University researchers have developed a blood test that quickly detects if someone has COVID-19 and predicts how severely the immune system will react to the infection, according to a new study coming out today in PLOS One.

1 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

31 Jan 2022

Study assesses anti-SARS-CoV-2 antibody response to mRNA-1273 vaccination over time

A new study has assessed the antibody responses to the mRNA-1273 Moderna vaccine over time.

31 Jan 2022

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Researchers from Moderna, the developers of one key vaccine, have been investigating its ability to protect against the Omicron variant.

31 Jan 2022

Growth factor can powerfully counter the harmful effects of inflammatory bowel disease

A growth factor protein produced by rare immune cells in the intestine can protect against the effects of inflammatory bowel disease (IBD), according to a new discovery from Weill Cornell Medicine researchers.

31 Jan 2022

New approach to make RNA vaccines easier to swallow

Like most vaccines, RNA vaccines have to be injected, which can be an obstacle for people who fear needles. Now, a team of MIT researchers has developed a way to deliver RNA in a capsule that can be swallowed, which they hope could help make people more receptive to them.

31 Jan 2022

RNA News and Research

Further Reading

UCLA researchers develop first human genomic transgenic mouse model of Huntington's disease

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

Representative structures of SARS-CoV-2 and development of therapeutic agents for targeting these proteins

Study reveals pet hamsters can acquire SARS-CoV-2 infection in real-life settings and transmit the virus back to humans

Study proposes Omicron variant may be derived from recombination of two early SARS-CoV-2 PANGO lineages

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Nanomedicine can be improved with proper and more predictive in vitro assays

Developing post-vaccination SARS-CoV-2 standard reference sera

Study: COVID-19 infections tend to be milder in fully vaccinated patients

Researchers discover why patients suffering with hypertension also have diabetes

New RNA therapies for the treatment of heart failure and organ fibrosis

SARS-CoV-2 entry at the cell surface facilitated by trypsin

New blood test quickly detects COVID-19 infection and disease severity

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Study assesses anti-SARS-CoV-2 antibody response to mRNA-1273 vaccination over time

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Growth factor can powerfully counter the harmful effects of inflammatory bowel disease

New approach to make RNA vaccines easier to swallow

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