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De novo antibody protein sequencing reveals novel functional and neutralizing antibodies post-SARS-CoV-2 vaccination

Rapid Novor has published a study that highlights the power of combining de novo antibody protein sequencing with conventional proteomics to uncover functional and neutralizing antibodies in human plasma following SARS-CoV-2 vaccination.

From Rapid Novor Inc 14 Oct 2024

Clec14a protein found to play vital role in regulating bone formation and density

The role of the C-type lectin domain containing 14A (Clec14a), a type-H endothelial protein, in coordinating osteoblast activity.

14 Oct 2024

A novel approach to understanding protein compartmentalization

In physics, a system composed of two substances can be modeled in accordance with classical mixture theory, which considers the fraction corresponding to each constituent and the interactions among constituents. Examples include the coexistence of high- and low-density phases in supercooled water and the coexistence of metal puddles in an insulating matrix in the Mott metal-insulator transition.

14 Oct 2024

Distinct fecal metabolites identified for non-invasive diagnosis of endometriosis

Researchers identify distinct gut microbiome metabolites in women with endometriosis, offering potential for non-invasive diagnosis and new therapies.

14 Oct 2024

Computational tools unlock the secrets of the genome

In collaboration with the International Conference on Research in Computational Molecular Biology (RECOMB), Genome Research publishes a collection of 20 computational methods and their applications in genomics including spatial, single-cell, and long-read sequencing.

13 Oct 2024

Chronic stress disrupts gut microbiota, promoting colorectal cancer growth

Cutting-edge research has uncovered how chronic stress disrupts the balance of gut microbiota to speed up the progression of colorectal cancer (CRC), opening new avenues for CRC prevention and treatment.

13 Oct 2024

AI model LucaProt uncovers 251,000 new RNA viruses, revealing hidden diversity worldwide

Researchers developed an AI model, LucaProt, that uncovered over 251,000 new RNA virus species, expanding our understanding of the RNA virosphere across global ecosystems.

13 Oct 2024

Ultra-rare gene variants drive coronary artery disease risk in European ancestry

Researchers found that ultra-rare genetic variants play a significant role in the heritability of coronary artery disease (CAD), particularly in individuals of European ancestry. These variants, especially those altering proteins or regulating genes in heart cells, pose higher risks than common variants.

13 Oct 2024

Indiana University scientists pioneer oculomics research with NIH support

Indiana University scientists with expertise in optometry and artificial intelligence are among the first three groups of researchers to receive support from a new program from the National Institutes of Health supporting the emerging field of "oculomics," which uses the eye as a lens on diseases that affect the whole body.

12 Oct 2024

New insights on protein degraders open doors to treatment for 'undruggable' diseases

Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called 'protein degraders' which can be deployed to combat what have previously been regarded as 'undruggable' diseases, including cancers and neurodegenerative diseases.

12 Oct 2024

Evaluating allogeneic transplant for TP53 mutated acute myeloid leukemia

A new editorial was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Transplant or no transplant for TP53 mutated AML."

12 Oct 2024

Anne Bang joins research to understand the genetic underpinnings of psychiatric conditions

Scientists have linked neuropsychiatric disorders, such as schizophrenia and autism, to changes in many genes involved in early brain development.

12 Oct 2024

New insights into stem cell control in plant meristems

Researchers from the University of Freiburg have identified the HAN molecule as an important regulator that controls plant growth in conjunction with WOX5.

12 Oct 2024

New computational pipeline revolutionizes personalized cancer vaccine design

Ludwig Cancer Research scientists have developed a full, start-to-finish computational pipeline that integrates multiple molecular and genetic analyses of tumors and the specific molecular targets of T cells and harnesses artificial intelligence algorithms to use its output to design personalized cancer vaccines for patients.

12 Oct 2024

Unique protein complex found to influence brain function and anxiety

Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function of brain cell connectivity, as well as in specific cognitive behaviors.

12 Oct 2024

Study unveils new molecular switch protecting cells from death

Researchers at LMU University Hospital have discovered a new molecular switch that protects against cell death.

12 Oct 2024

Umeå University discovers critical mechanisms in stem cell differentiation

A study led by Umeå University, Sweden, presents new discoveries about how stem cells develop and transition into specialised cells. The discovery can provide increased understanding of how cells divide and grow uncontrollably so that cancer develops.

12 Oct 2024

Protein discovery offers insights into bone health and potential treatments for osteoporosis

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

12 Oct 2024

Researchers develop innovative mouse model for studying cancer immunotherapy

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells - by using engineered antibodies - or by simply providing it with new cells, pre-equipped to search and destroy cancer.

12 Oct 2024

Innovative tissue expansion technique transforms conventional microscopy capabilities

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before imaging it - a technique that allows them to achieve nanoscale resolution with a conventional light microscope.

12 Oct 2024

B Cell News and Research

De novo antibody protein sequencing reveals novel functional and neutralizing antibodies post-SARS-CoV-2 vaccination

Clec14a protein found to play vital role in regulating bone formation and density

A novel approach to understanding protein compartmentalization

Distinct fecal metabolites identified for non-invasive diagnosis of endometriosis

Computational tools unlock the secrets of the genome

Chronic stress disrupts gut microbiota, promoting colorectal cancer growth

AI model LucaProt uncovers 251,000 new RNA viruses, revealing hidden diversity worldwide

Ultra-rare gene variants drive coronary artery disease risk in European ancestry

Indiana University scientists pioneer oculomics research with NIH support

New insights on protein degraders open doors to treatment for 'undruggable' diseases

Evaluating allogeneic transplant for TP53 mutated acute myeloid leukemia

Anne Bang joins research to understand the genetic underpinnings of psychiatric conditions

New insights into stem cell control in plant meristems

New computational pipeline revolutionizes personalized cancer vaccine design

Unique protein complex found to influence brain function and anxiety

Study unveils new molecular switch protecting cells from death

Umeå University discovers critical mechanisms in stem cell differentiation

Protein discovery offers insights into bone health and potential treatments for osteoporosis

Researchers develop innovative mouse model for studying cancer immunotherapy

Innovative tissue expansion technique transforms conventional microscopy capabilities

Using single B cell screening to boost antibody discovery eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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