Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

A biochemistry instructor curious about an enzyme discovered in the damaged neurons of people with multiple sclerosis made a leap toward a potential cure for countless neurodegenerative ills.

7 Aug 2018

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

AstraZeneca and Merck, known as MSD outside the U.S. and Canada, today announced that the European Medicines Agency (EMA) has granted orphan designation to selumetinib, a MEK 1/2 inhibitor, for the treatment of neurofibromatosis type 1 (NF1).

3 Aug 2018

Insulin resistance largely undetected in non-diabetic patients with Parkinson's disease

Almost two-thirds of non-diabetic patients with Parkinson's disease may be insulin resistant, despite having normal blood sugar, report scientists in the Journal of Parkinson's Disease.

3 Aug 2018

New study uses metabolomics to compare lipid profiles of infant formulas and human milk

Metabolomics is the latest omics systems science technology with emerging applications towards psychiatry, personalized medicine, and most recently, precision nutrition research.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Study of neuroprotective microRNAs may lead to new avenues for treating tauopathies

Alzheimer's disease is an increasingly prevalent, neurodegenerative condition that erodes memory and other cognitive functions. Treatments for this complex disease have been elusive, although researchers have previously uncovered its main biological features: amyloid-beta plaques and tau tangles.

2 Aug 2018

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline - or pH - chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

2 Aug 2018

Folic acid may prevent language delays in children of mothers with epilepsy

Women who take epilepsy drugs while they are pregnant may have a lower risk of having a child with delays in language skills if they take folic acid supplements before and early in pregnancy, according to a study published in the August 1, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology.

2 Aug 2018

Study: More than 90% of people caring for a family member with dementia experience poor sleep

More than 90 percent of people caring for a family member with dementia experience poor sleep, according to new research by the University at Buffalo School of Nursing.

2 Aug 2018

Alzheimer's drug may prevent disease progression if used before symptoms appear

About 50 percent of people who reach the age of 85 will develop Alzheimer's disease. Most will die within about five years of exhibiting the hallmark symptoms of the disease - severe memory loss and a precipitous decline in cognitive function.

2 Aug 2018

Peer comparison letters lead to persistent decrease in antipsychotic prescribing

A study led by Columbia University's Mailman School of Public Health has found that letters targeting high prescribers of Seroquel, an antipsychotic with potentially harmful side effects in the elderly, significantly reduced the number of prescriptions for patients in Medicare.

2 Aug 2018

New method to construct brain networks improves accuracy of diagnosing Alzheimer's disease

Researchers have developed a new method for constructing personal brain networks using multiple structural features to improve the accuracy of diagnosing Alzheimer's disease and mild cognitive impairment

1 Aug 2018

Glaucoma Research Foundation-funded research makes breakthrough in treatment of glaucoma

Glaucoma Research Foundation, a national non-profit organization dedicated to finding a cure for glaucoma, today announced a team of neuroscience researchers, led by Adriana Di Polo, PhD, at University of Montreal, have made a major breakthrough in the treatment of glaucoma.

31 Jul 2018

Alzheimer’s-in-a-dish model made better with microfluidic system

Researchers from Massachusetts have used a microfluidic device to incorporate neuroinflammation into the Alzheimer's-in-a-dish model for drug discovery.

31 Jul 2018

Research may help advance search for more effective drugs to treat Alzheimer's disease

Two new studies published by investigators from Brigham and Women's Hospital illustrate that not all forms of amyloid-beta protein - the protein thought to initiate Alzheimer's disease - play an equally menacing role in the progress of the disease.

31 Jul 2018

Study: Reducing systolic blood pressure lowers MCI, dementia risk

Lowering one's blood pressure is beneficial not only for the heart, but also for the mind. For the first time, researchers have proved that lowering systolic blood pressure to 120 mm Hg or less reduces the risk of mild cognitive impairment, which in turn, reduces one's risk of developing Alzheimer's disease or dementia.

27 Jul 2018

Targeting mossy cells may offer new strategy for treating brain disorders

A small population of brain cells deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.

27 Jul 2018

Pilot study uses naturalistic driving approach to examine self-regulation behavior of older adults with AD

Driving is a complex task that involves perceptual, motor and cognitive abilities. These abilities may be affected in early Alzheimer Disease (AD) patients.

27 Jul 2018

Research findings may offer new path to treat or prevent neurodegenerative diseases

Aging vessels connecting the brain and the immune system play critical roles in both Alzheimer's disease and the decline in cognitive ability that comes with time, new research reveals.

26 Jul 2018

Alzheimer's Disease News and Research

Further Reading

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

Insulin resistance largely undetected in non-diabetic patients with Parkinson's disease

New study uses metabolomics to compare lipid profiles of infant formulas and human milk

Scientists map regulatory landscape of mouse genome at single-cell resolution

Study of neuroprotective microRNAs may lead to new avenues for treating tauopathies

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Folic acid may prevent language delays in children of mothers with epilepsy

Study: More than 90% of people caring for a family member with dementia experience poor sleep

Alzheimer's drug may prevent disease progression if used before symptoms appear

Peer comparison letters lead to persistent decrease in antipsychotic prescribing

New method to construct brain networks improves accuracy of diagnosing Alzheimer's disease

Glaucoma Research Foundation-funded research makes breakthrough in treatment of glaucoma

Alzheimer’s-in-a-dish model made better with microfluidic system

Research may help advance search for more effective drugs to treat Alzheimer's disease

Study: Reducing systolic blood pressure lowers MCI, dementia risk

Targeting mossy cells may offer new strategy for treating brain disorders

Pilot study uses naturalistic driving approach to examine self-regulation behavior of older adults with AD

Research findings may offer new path to treat or prevent neurodegenerative diseases

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