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Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Heart development as it happens in vivo, or in a living organism, is a complex process that has traditionally been difficult to mimic in vitro, or in the laboratory.

16 Sep 2020

NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Materials scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a new pill which uses the stomach as a drug reservoir and delivers medicines slowly over time to patients with Parkinson's disease (PD).

16 Sep 2020

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Curi Bio today announced the Mantarray™ platform for human-relevant 3D engineered muscle tissue (EMT) analysis.

From Curi Bio 16 Sep 2020

Physical exercise protocol can mitigate the severity of Parkinson's disease

Freezing of gait, one of the most incapacitating symptoms of Parkinson's disease, manifests as sudden, short episodes of an inability to move the feet forward despite the intention to walk.

16 Sep 2020

Newly identified mechanism regulates the distensibility of the heart

A healthy heart beats 50 to 100 times a minute and pumps 8,000 litres of blood around our body every day. A precondition for this function is the elasticity of the cardiac walls, which dilate as blood flows in (diastole) and contract again as the blood flows out (systole).

15 Sep 2020

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring (fibrosis).

15 Sep 2020

New strategies may be needed to reduce risk of falls in Alzheimer’s patients

To better understand why people without cognitive symptoms are at risk of falling, first author Audrey Kelemen, a graduate student in Stark's lab, and colleagues followed 83 people over age 65 for a year.

15 Sep 2020

Higher doses of Botox may lead to bone loss, shows study

Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers at NYU College of Dentistry.

15 Sep 2020

Enzyme insight could lead to new treatment approach for diabetic patients

Research led by the Centenary Institute has discovered that the lack of an enzyme in the liver called sphingosine kinase 2 results in pronounced insulin resistance and glucose intolerance, both symptoms of early stage type 2 diabetes.

15 Sep 2020

NIH and FDA examine serious side effect that surfaced in COVID vaccine trial

The Food and Drug Administration is weighing whether to follow British regulators in resuming a coronavirus vaccine trial that was halted when a participant suffered spinal cord damage, even as the National Institutes of Health has launched an investigation of the case.

14 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

Research provides insight into how muscles and fat tissue communicate to improve fitness

Why does exercise training make you more fit? It's well established that exercising enhances insulin sensitivity and improves our metabolism that, in turn, increases exercise performance. But the biological mechanisms underlying this adaptation are not fully understood.

14 Sep 2020

Cardiac MRI effective in identifying inflammation of the heart muscle in athletes

A cardiac MRI is effective in identifying inflammation of the heart muscle in athletes and can help determine when those who have recovered from COVID-19 can safely return to play in competitive sports, according to a new study by researchers at The Ohio State University Wexner Medical Center.

12 Sep 2020

Yale researchers identify possible treatment for Duchenne muscular dystrophy

Researchers at Yale have identified a possible treatment for Duchenne muscular dystrophy (DMD), a rare genetic disease for which there is currently no cure or treatment, by targeting an enzyme that had been considered "undruggable."

12 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Novel discovery could lead to stem cell-based treatment for heart failure

Blocking an enzyme linked with inflammation makes it possible for stem cells to repair damaged heart tissue, new research from UC Davis Health scientists shows.

10 Sep 2020

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalized transplants for children with intestinal failure, according to a study published in Nature Medicine today (Monday 7th September).

10 Sep 2020

Heart Research UK awards grant to support University of Leeds project

A project at the university of Leeds aiming to improve the investigation and management of patients with suspected angina has received a grant of almost £150,000 from national charity Heart Research UK.

10 Sep 2020

Muscle News and Research

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Physical exercise protocol can mitigate the severity of Parkinson's disease

Newly identified mechanism regulates the distensibility of the heart

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

New strategies may be needed to reduce risk of falls in Alzheimer’s patients

Higher doses of Botox may lead to bone loss, shows study

Enzyme insight could lead to new treatment approach for diabetic patients

NIH and FDA examine serious side effect that surfaced in COVID vaccine trial

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Research provides insight into how muscles and fat tissue communicate to improve fitness

Cardiac MRI effective in identifying inflammation of the heart muscle in athletes

Yale researchers identify possible treatment for Duchenne muscular dystrophy

New antitumor vaccines control melanoma growth in preclinical models

Effective, simple, safe self-amplifying RNA vaccines

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Novel discovery could lead to stem cell-based treatment for heart failure

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Heart Research UK awards grant to support University of Leeds project

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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