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Researchers supplement synthetic biology toolkit to streamline investigations into genetic code expansion

One of modern biologists' most ambitious goals is to learn how to expand or otherwise modify the genetic code of life on Earth, in order to make new, artificial life forms.

30 Sep 2021

ACTG to present data highlighting a new therapeutic for COVID-19 at the virtual IDWeek 2021

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that Teresa H. Evering, M.D., M.S., a co-lead investigator (with Eric S. Daar, M.D.) for BRII-196/BRII-198 in the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies, will present data for the monoclonal antibody combination at the virtual IDWeek 2021 conference, taking place September 29 – October 3, 2021.

30 Sep 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Now, in a new news study posted to the bioRxiv* preprint server, researchers have successfully induced similar chronicity associated with SARS-CoV-2 infection in MISTRG6-hACE2 humanized mice.

29 Sep 2021

Scientists offers new hope for future treatment of sepsis

Sepsis, the body's life-threatening response to infection affecting about 1.7 million adults in the United States each year, can lead to multisystem organ failure with a high mortality rate.

29 Sep 2021

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

A new approach to 'prime' the tumor environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer.

29 Sep 2021

Novel small-molecule therapy shows promise against deadly pediatric leukemia

Mount Sinai researchers have developed a therapy that shows promise against a deadly pediatric leukemia. The small-molecule therapy was highly effective in fighting a type of acute myeloid leukemia in both in vitro and in vivo experiments, according to research published in Science Translational Medicine in September.

29 Sep 2021

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Buck Institute professors Judith Campisi, PhD and Lisa Ellerby PhD, have been awarded a $14.3 million grant from the NIH's National Institute of Aging to study cellular senescence, one of the major hallmarks of aging, as a driver of Alzheimer's disease and other age-related dementias.

29 Sep 2021

Understanding noise-related hearing loss through changes in RNA levels

A growing number of people are suffering from hearing loss due to exposure to loud noises from heavy machinery, concerts, or explosions.

29 Sep 2021

Patient-specific whole-heart computational models provide insights for personalized treatment

Whole-heart ventricular modeling has come a long way in recent years and is currently witnessing the evolution of a variety of computational approaches, especially within the realm of personalized technologies for patient-specific clinical applications.

29 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

Combination of two drugs may help pancreatic and liver cancer patients

A drug candidate discovered and developed decades ago in the laboratory of UC Davis distinguished professor Bruce Hammock may help control the body's raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

29 Sep 2021

Scientists turn into molecular detectives to find clues to why certain cancer therapies stop working

A new research study at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) turns cancer scientists into molecular detectives, searching for clues for why certain cancers are able to spread and evolve by studying tissues collected within hours of death.

29 Sep 2021

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

The University of Texas MD Anderson Cancer Center and BostonGene Corporation today announced a strategic alliance to advance the development and clinical integration of multiplatform biomarker signatures.

28 Sep 2021

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that SAB-185, a novel polyclonal antibody therapy, has demonstrated safety and efficacy in phase 2 that meet the criteria for graduation to phase 3 in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial (ACTG A5401).

28 Sep 2021

COVID Moonshot receives key funding to accelerate drug discovery efforts

The COVID Moonshot, a non-profit, open-science consortium of scientists from around the world dedicated to the discovery of globally affordable and easily-manufactured antiviral drugs against COVID-19 and future viral pandemics has received key funding of £8 million from Wellcome, on behalf of the Covid-19 Therapeutics Accelerator.

28 Sep 2021

New 'reporter viruses' make it easier to observe SARS-CoV-2 in real time

A version of SARS-CoV-2, the virus that causes COVID-19 disease, has been successfully modified to glow brightly in cells and animal tissues, providing a real-time way to track the spread and intensity of viral infection as it happens in animal models, researchers at Texas Biomedical Research Institute report in the journal The Proceedings of the National Academy of Sciences.

27 Sep 2021

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Researchers in the UK and Germany have provided evidence for a novel mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – binds to human host cells.

27 Sep 2021

WHO urges to address the high price and limited production of antibody combination for COVID-19

The World Health Organization (WHO) welcomes the addition of another therapeutic to the world's arsenal against COVID-19, but urges producing companies and governments to address the high price and limited production of the Regeneron antibody combination and ensure safe and appropriate handling of the medicine.

27 Sep 2021

Global leaders underline their commitment to ensure equitable access to COVID-19 vaccines

Global leaders attending the Global COVID-19 Summit hosted by the United States have again underlined their commitment to ensuring equitable access to COVID-19 vaccines for all countries through COVAX – noting that equitable access is essential to end the acute stage of the pandemic.

27 Sep 2021

Global leaders align with the ACT-Accelerator to end COVID-19 pandemic

Global leaders attending the US-hosted Global COVID-19 Summit on 22 September re-affirmed their commitment to ending the acute phase of the pandemic, and the goals of the ACT-Accelerator, by agreeing targets to provide equitable access to COVID-19 tests, treatments, and vaccines.

27 Sep 2021

Therapeutics News and Research

Researchers supplement synthetic biology toolkit to streamline investigations into genetic code expansion

ACTG to present data highlighting a new therapeutic for COVID-19 at the virtual IDWeek 2021

Scientists describe SARS-CoV-2 uptake in tissue-resident human macrophages enhanced by virus-specific antibodies

Scientists offers new hope for future treatment of sepsis

New 'priming' approach may improve the efficacy of chemotherapy for pancreatic cancer

Novel small-molecule therapy shows promise against deadly pediatric leukemia

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Understanding noise-related hearing loss through changes in RNA levels

Patient-specific whole-heart computational models provide insights for personalized treatment

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Combination of two drugs may help pancreatic and liver cancer patients

Scientists turn into molecular detectives to find clues to why certain cancer therapies stop working

BostonGene and MD Anderson collaborate to advance the development of multiplatform biomarker signatures

Novel polyclonal antibody therapy meets the criteria for graduation to phase 3 in ACTIV-2 trial

COVID Moonshot receives key funding to accelerate drug discovery efforts

New 'reporter viruses' make it easier to observe SARS-CoV-2 in real time

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

WHO urges to address the high price and limited production of antibody combination for COVID-19

Global leaders underline their commitment to ensure equitable access to COVID-19 vaccines

Global leaders align with the ACT-Accelerator to end COVID-19 pandemic

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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