Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

MGH study points toward potential strategy for treating X-linked disorders

A study from a team of Massachusetts General Hospital (MGH) investigators points toward a potential strategy for treating X-linked disorders - those caused by mutations in the X chromosome - in females.

4 Jan 2018

Researchers discover novel genes responsible for Alzheimer's disease

Researchers have identified several new genes responsible for Alzheimer's disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

3 Jan 2018

Researchers find more precise, neuroprotective approach to fix MS-damaged nerves

Gene expression in specific cells and in specific regions can provide a more precise, neuroprotective approach than traditional treatments for neurological diseases.

26 Dec 2017

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Treating ovariectomized mice with a combination of conjugated estrogens and the drug bazedoxifene triggers the expression of genes that improve metabolism and prevent weight gain - without stimulating the uterus and increasing risks of reproductive cancer, a new study suggests.

22 Dec 2017

Study finds new marker to detect fatal breast cancer

A new study conducted at the University College London, UK, found a new marker that has the capacity to help diagnose fatal breast cancer up to one year earlier than existing methods.

22 Dec 2017

Epigenetics: A New Tool for Forensic Detectives

Developing analytical methods can help the triers of fact, judges and juries, better understand the events surrounding the circumstances of a crime. In forensic analysis, we are talking about determining the identity of unknown individuals through DNA and using DNA and other chemical signatures to determine and clarify the circumstances of the crime.

From Pittcon 20 Dec 2017

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

19 Dec 2017

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

When a coronary artery is obstructed by atheroma, blood flow is depressed or even arrested. This causes hypoxia of cardiac cells associated with the deprivation of nutrients. In clinic, the first objective is to restore blood flow. However, this is associated with a burst in oxidation of cellular proteins and lipids. This oxidation enhances cell death and participates to the so-called reperfusion injury.

From Logos Biosystems 18 Dec 2017

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Predicting how patients will respond to anti-cancer therapies can be vital in informing clinical decisions and improving treatment outcome.

15 Dec 2017

Scientists unravel mystery of how immune cells remember infections decades later

A perplexing question in immunology has been, how do immune cells remember an infection or a vaccination so that they can spring into action decades later? Research led by scientists at the University of California, Berkeley, in collaboration with investigators at Emory University, has found an answer: A small pool of the same immune cells that responded to the original invasion remain alive for years, developing unique features that keep them primed and waiting for the same microbe to re-invade the body.

14 Dec 2017

Studies reveal possibility for memory T cells to serve a dual purpose

Scientists of two new complementary studies researching mice and humans claim that they have the strongest evidence yet that memory T cells responsible for long-term immune protection also serve an additional role.

14 Dec 2017

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myotonic dystrophy (DM) is the most common form of genetic muscular dystrophy that begins in adulthood. DM is characterized by progressive muscle wasting and weakness. People with this disorder often have prolonged muscle contractions (myotonic) and are not able to relax certain muscles after use.

12 Dec 2017

Myriad Genetics announces new data on EndoPredict test at 2017 San Antonio Breast Cancer Symposium

Myriad Genetics, Inc., a leader in molecular diagnostics and personalized medicine, today announced new results from two studies with EndoPredict are being featured at the 2017 San Antonio Breast Cancer Symposium in San Antonio, Texas.

12 Dec 2017

Researchers find new role for SHARPIN protein in melanoma growth

Researchers at Sanford Burnham Prebys Medical Discovery and the Technion in Israel have found a new role for the SHARPIN protein. In addition to being one of three proteins in the linear ubiquitin chain assembly complex, regulating NFκB and other inflammatory molecules, SHARPIN modulates PRMT5, an epigenetic master switch that controls several proteins linked to melanoma. The research was published in The Journal of Clinical Investigation.

12 Dec 2017

Gene Expression News and Research

Further Reading

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

MGH study points toward potential strategy for treating X-linked disorders

Researchers discover novel genes responsible for Alzheimer's disease

Researchers find more precise, neuroprotective approach to fix MS-damaged nerves

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Study finds new marker to detect fatal breast cancer

Epigenetics: A New Tool for Forensic Detectives

Study finds combination therapy as effective strategy to treat ovarian cancers

Spatial deconvolution of marker expression in whole heart subjected to ischemia-reperfusion

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Scientists unravel mystery of how immune cells remember infections decades later

Studies reveal possibility for memory T cells to serve a dual purpose

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myriad Genetics announces new data on EndoPredict test at 2017 San Antonio Breast Cancer Symposium

Researchers find new role for SHARPIN protein in melanoma growth

Researchers discover potential regulator essential for killer T cells to reside in tumors

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Scientists discover how axons in developing visual system stabilize their connections

Researchers discover how unusually long strands of RNA work in skin cells

Researchers establish function of long RNA strands in skin development and disease

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