Antibodies News and Research

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Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from the phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Research ushers in a new era of hope for patients with primary immune thrombocytopenia

More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening bleeding, were able to maintain safe platelet counts without serious bleeding episodes for at least one year.

9 Dec 2025

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Early-life RSV infection and parental allergy interact to substantially increase childhood asthma risk, supported by population data from more than 1.5 million children and mechanistic mouse experiments. The study shows that viral infection reprograms neonatal immune responses by altering how maternally transferred allergen-specific antibodies are handled, driving long-term allergic airway disease.

8 Dec 2025

Combination therapy may boost survival for people with aggressive lymphoma

A new clinical trial suggests that pairing bispecific antibodies and antibody-drug conjugates with CAR T-cell therapy may sharply boost one-year progression-free survival for people with aggressive lymphoma.

8 Dec 2025

Poor dietary iron weakens lung memory T cells after flu infection

Dietary iron deficiency in mice alters lung T cell activation during influenza infection and leads to memory T cells that are present in normal or increased numbers but have impaired antiviral cytokine responses. These functional deficits are most pronounced in lung CD8-positive memory T cells and persist even under optimal recall conditions.

8 Dec 2025

New trial shows major survival gains with epcoritamab added to standard R2 therapy

In a new trial, patients with follicular lymphoma had a significantly higher response to treatment and a nearly 80% reduction in the risk of death or disease progression if they received epcoritamab in addition to the standard second-line regimen versus the standard regimen alone.

7 Dec 2025

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

According to a new trial, patients with chronic lymphocytic leukemia (CLL) show comparable outcomes whether they receive a single-agent treatment indefinitely or a combination treatment for a fixed period of time.

7 Dec 2025

Injectable scaffold vaccine shows strong protection against implant-related MRSA

Research reveals that silica scaffolds can train the immune system against S. aureus, offering a novel approach to prevent orthopedic device infections.

4 Dec 2025

New rapid test distinguishes real HIV infections from vaccine-related false positives

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have contracted the virus and an additional 44.1 million have died from related causes.

3 Dec 2025

Gene variant linked to higher risk of chronic rejection after lung transplant

About one third of lung transplant recipients have a genetic variant that makes them more likely to develop chronic lung allograft dysfunction (CLAD), the primary cause of mortality after lung transplantation.

2 Dec 2025

Killer T cell traits explain why some people achieve long-term HIV remission after treatment

Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV medications and maintain control of the virus for years, while others given the same treatment do not achieve this remission.

1 Dec 2025

Combination immunotherapy may be the key to control HIV without long-term antiviral treatment

A new study from UC San Francisco shows it may be possible to control HIV without long-term antiviral treatment - an advance that points the way toward a possible cure for a disease that affects 40 million people around the world.

1 Dec 2025

Early-infancy infection with RSV increases the risk of developing childhood asthma

Belgian scientists from VIB and Ghent University (UGent), together with Danish collaborators, have uncovered compelling evidence that early-infancy infection with respiratory syncytial virus (RSV) significantly increases the risk of developing childhood asthma-especially in children with a family history of allergy or asthma.

29 Nov 2025

Extending the reach of Amperia™: Simplifying his-tagged protein quantification across expression and development workflows

Discover how Abselion’s Amperia™ platform delivers fast, reproducible His-tagged protein quantification with minimal prep, even from crude lysates.

From Abselion 27 Nov 2025

Global Virus Network outlines priorities as Marburg virus emerges in Ethiopia

The Global Virus Network (GVN), a coalition of leading human and animal virologists in more than 40 countries dedicated to advancing pandemic preparedness through research, education and training, and global health solutions, today issued a statement on the newly confirmed outbreak of Marburg virus disease (MVD) in southern Ethiopia.

27 Nov 2025

Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's disease

Lecanemab, sold under the name Leqembi, is a monoclonal antibody therapy for Alzheimer's disease that clears toxic amyloid plaques and delays cognitive decline.

25 Nov 2025

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to humans.

24 Nov 2025

Antibodies News and Research

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Research ushers in a new era of hope for patients with primary immune thrombocytopenia

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Combination therapy may boost survival for people with aggressive lymphoma

Poor dietary iron weakens lung memory T cells after flu infection

New trial shows major survival gains with epcoritamab added to standard R2 therapy

Fixed-duration therapy works as effectively as continuous treatment for chronic lymphocytic leukemia

Injectable scaffold vaccine shows strong protection against implant-related MRSA

New rapid test distinguishes real HIV infections from vaccine-related false positives

Gene variant linked to higher risk of chronic rejection after lung transplant

Killer T cell traits explain why some people achieve long-term HIV remission after treatment

Combination immunotherapy may be the key to control HIV without long-term antiviral treatment

Early-infancy infection with RSV increases the risk of developing childhood asthma

Extending the reach of Amperia™: Simplifying his-tagged protein quantification across expression and development workflows

Global Virus Network outlines priorities as Marburg virus emerges in Ethiopia

Study elucidates how anti-amyloid antibody therapy lecanemab works in Alzheimer's disease

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

Single-cell RNA sequencing uncovers diverse CD4⁺ T-cell subtypes in pediatric lupus

COVID vaccine tech could help prevent muscle damage from snakebites

Promising long-term vaccine for Crimean-Congo hemorrhagic fever developed

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