Central Nervous System News and Research

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Insilico Medicine partners with Inimmune to advance immunotherapeutic discovery

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced that the company has achieved a groundbreaking collaboration with Inimmune, which will utilize Chemistry42, Insilico's proprietary generative artificial intelligence (AI) technology to accelerate the discovery and development of next-generation immunotherapeutics.

5 Sep 2024

Research uncovers unexpected origin of ataxia outside the cerebellum

A new study by the University of Turku and Turku University Hospital in Finland investigated the origin of ataxia in the brain of patients with stroke.

5 Sep 2024

New insights into stiff-person syndrome, advancing diagnosis and treatment

Research explores the complexities of diagnosing and treating stiff-person syndrome, emphasizing the uncertain role of GAD antibodies and the promise of novel therapies.

5 Sep 2024

New immunotherapy approach shows promise for minimizing spinal cord injury damage

WashU Medicine researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells.

4 Sep 2024

Introducing a blood-based test for minimally invasive detection of IDH1 mutant gliomas

Glioma represents the most common central nervous system cancer in adults. The current classification scheme uses molecular alterations, particularly IDH1.R132H, to stratify lesions into distinct prognostic groups.

30 Aug 2024

Study explores link between prostate cancer treatment and Alzheimer’s disease

Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.

29 Aug 2024

Study reveals a new target for universal treatment for autoimmune diseases

More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was at Harvard, discovered a type of T cell in humans that suppresses the immune system; they later found that these so-called regulatory T cells, when defective, are an underlying cause of autoimmune disease, specifically multiple sclerosis (MS).

28 Aug 2024

Psychedelics: A new hope for substance abuse treatment

Study explores the history and current state of psychedelic research for treating substance abuse disorders, highlighting challenges like restrictive policies, lack of funding, and the need for recognition of traditional and modern therapeutic practices.

28 Aug 2024

SARS-CoV-2 evolves differently in the brain, revealing critical insights into viral tropism

Study investigates the evolution of SARS-CoV-2 within the central nervous system (CNS) compared to the lungs in mice, revealing higher viral divergence in the CNS and highlighting the critical role of the furin cleavage site (FCS) in viral tropism and compartmentalization.

27 Aug 2024

Scientists discover how a gut insulin antagonist controls fat loss in C. elegans by modulating brain signals

Researchers have identified an endogenous insulin antagonist, INS-7, in Caenorhabditis elegans that modulates fat loss by inhibiting a gut-to-brain signaling pathway involving the neuropeptide FLP-7.

27 Aug 2024

FDA-approved Alzheimer's drug induces torpor-like state in tadpoles

27 Aug 2024

Multiple sclerosis patients less likely to have molecular hallmarks of Alzheimer's disease

People with multiple sclerosis (MS) are far less likely than those without the condition to have the molecular hallmarks of Alzheimer's disease, according to new research from Washington University School of Medicine in St. Louis.

23 Aug 2024

Mutation in SARS-CoV-2 spike protein enhances brain infection

Scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system.

23 Aug 2024

Study reveals how brain pathways aid motor recovery after injury

Stroke and spinal cord injuries can severely impair motor functions, and understanding how to promote recovery is a critical challenge.

23 Aug 2024

Novel screening method for blood-brain barrier penetration

Scientists at Southwest Research Institute have developed a new screening method to identify drug formulations that can penetrate the blood-brain barrier (BBB), to facilitate treatment of brain diseases and conditions.

23 Aug 2024

FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

The role of the gut microbiota in multiple sclerosis: A scientometric analysis reveals key research trends

Researchers examine the relationship between gut microbiota and multiple sclerosis.

21 Aug 2024

New implantable device could revolutionize opioid overdose response

A swine model to demonstrate the potential of an implantable system for opioid safety (iSOS).

19 Aug 2024

Breakthrough in understanding cell communication during inflammation

Indiana University School of Medicine researchers have made significant progress in understanding how cells communicate during inflammation.

14 Aug 2024

Can odors help fight infection? Nematode research suggests so

Researchers from the University of California, Berkeley, used the nematode model Caenorhabditis elegans to determine whether the olfactory nervous system could non-autonomously control the mitochondrial unfolded protein response in response to cellular stress.

12 Aug 2024