Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

C-Path’s TRxA awards $250,000 grant to develop novel treatment for type 1 diabetes

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) proudly announced today a $250,000 grant award aimed at developing a novel treatment for type 1 diabetes (T1D).

19 Jun 2025

New dual-adjuvant vaccine strategy offers hope in the fight against HIV

In the quest to develop an effective HIV vaccine, scientists from Scripps Research have made a significant leap forward. They found that a two-part delivery strategy can train the immune system to produce a stronger response to HIV, offering new hope in the fight against one of the world's most elusive viruses.

19 Jun 2025

New switchable CAR-T therapy enters phase 1 trial for advanced breast cancer

The Calibr-Skaggs Institute for Innovative Medicines, the drug development division of Scripps Research, today announced a milestone in cancer treatment with the dosing of the first patient in a phase 1 trial (NCT06878248) evaluating CLBR001 + ABBV-461, a modular, switchable chimeric antigen receptor T cell (sCAR-T) therapy in patients with advanced or metastatic breast cancer who have no suitable treatment options.

18 Jun 2025

PDE3 inhibitors show promise in promoting bone growth

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone.

17 Jun 2025

Indiana University researcher helps develop FDA-approved Alzheimer’s test

A first-of-its-kind blood test to detect amyloid plaques in the brain associated with Alzheimer's disease recently received clearance from the U.S. Food and Drug Administration. An Indiana University School of Medicine researcher who helped lead the discovery and development of one of the biomarkers the test identifies hopes it will provide greater access and a more accurate diagnosis for patients.

16 Jun 2025

AI and film animation tools lead to breakthrough in coronavirus drug discovery

About 30% of all respiratory tract infections are caused by coronaviruses, leading to widespread illnesses and, in some cases, to epidemic and even pandemic outbreaks, as we experienced with the COVID-19 pandemic.

13 Jun 2025

Researchers reverse muscle stem cell aging with Prostaglandin E2

The population across developed countries is getting older and the associated frailty and debilitation are becoming major health problems.

13 Jun 2025

Chronic hyponatremia causes anxiety-like behaviors by disrupting brain chemistry

Hyponatremia, or low blood sodium concentration, is typically viewed as a symptomless condition-until recently.

12 Jun 2025

How Fluidics is Powering Modern Healthcare and Medical Device Innovation

The future of fluidics in healthcare: Blake Webb shares trends in automation and microfluidics that are reshaping medical diagnostics and laboratory processes.

From Fluid Metering, Inc. 12 Jun 2025

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

Discover how 3D biology, automation, and AI are revolutionizing drug discovery, improving predictive accuracy, and accelerating research.

From Molecular Devices UK Ltd 12 Jun 2025

New open access tool could accelerate drug discovery

Scientists at Northwestern University have developed the largest open-access resource of its kind to help researchers shave off months of early-stage drug development time by allowing them to better understand diseases and find potential treatments.

12 Jun 2025

Unexpected protein production in immune cells may fuel gut inflammation

Scientists have discovered that certain immune cells — called neutrophils — can start making a protein called DUOX2 that they usually do not produce.

11 Jun 2025

Enhanced Genomics appoints Dietrich Stephan, Ph.D. as Chair of the Board to lead ambitious growth strategy

Enhanced Genomics (‘Enhanced’ or ‘the Company’), the biotechnology company pioneering 3D multi-omics to rapidly identify high-confidence, genetically validated drug targets for common diseases, today announced the appointment of Dietrich Stephan, Ph.D. as Chair of the Board of Directors.

11 Jun 2025

Dr. Stephen Ross’s research into psychedelic medicine expands therapeutic frontiers

In a comprehensive Genomic Press Interview published today, Dr. Stephen Ross, a leading figure in psychedelic medicine at New York University (NYU), reveals how a serendipitous conversation in 2006 launched his journey into investigating psychedelic compounds as potential breakthrough treatments for some of psychiatry's most challenging conditions.

10 Jun 2025

CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development

CN Bio, a leading provider of Organ-on-a-chip (OOC) systems and solutions that accelerate drug discovery and development workflows, has introduced two new animal microphysiological system (MPS) models that enhance translatability in preclinical drug safety and toxicology assessments to its Contract Research Services (CRS). Building upon the Company's FDA-recognized drug induced liver injury (DILI) assay, the expanded offering enables rapid, comparative studies between commonly used animal and human models to flag interspecies differences early, and better informs in vivo study design.

10 Jun 2025

Patient-derived xenograft models may become an indispensable tool in precision oncology

Cancer remains one of the most pressing global health challenges, with millions of new diagnoses each year. While precision medicine and targeted therapies have transformed treatment strategies, many patients still face drug resistance and disease recurrence.

10 Jun 2025

Unveiling the biological frontier: CRAIC Technologies Circular Dichroism Microspectrometers pioneer molecular insights

CRAIC Technologies is proud to introduce Circular Dichroism Microspectroscopy. The field of biology is witnessing a transformative leap forward with the advent of Circular Dichroism (CD) Microspectroscopy, an innovative analytical technique that bridges micron-scale precision with biological applications.

From CRAIC Technologies, Inc. 5 Jun 2025

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

Researchers report that rentosertib, an AI-discovered TNIK inhibitor, showed promising safety and potential to improve lung function in patients with idiopathic pulmonary fibrosis in a 12-week phase 2a clinical trial. The highest dose group demonstrated a trend toward increased forced vital capacity, especially among patients not receiving standard antifibrotic therapy, supporting further clinical investigation.

4 Jun 2025

FDA approves ENCELTO implant to preserve sight in people with macular telangiectasia type 2

For people diagnosed with macular telangiectasia type 2 (MacTel)-a rare and slowly progressing retinal disease-there have been no FDA-approved (or other) treatments to slow or stop vision loss.

4 Jun 2025

AI and human scientists collaborate to discover new cancer drug combinations

An 'AI scientist', working in collaboration with human scientists, has found that combinations of cheap and safe drugs – used to treat conditions such as high cholesterol and alcohol dependence – could also be effective at treating cancer, a promising new approach to drug discovery.

4 Jun 2025

Drug Discovery News and Research

Further Reading

C-Path’s TRxA awards $250,000 grant to develop novel treatment for type 1 diabetes

New dual-adjuvant vaccine strategy offers hope in the fight against HIV

New switchable CAR-T therapy enters phase 1 trial for advanced breast cancer

PDE3 inhibitors show promise in promoting bone growth

Indiana University researcher helps develop FDA-approved Alzheimer’s test

AI and film animation tools lead to breakthrough in coronavirus drug discovery

Researchers reverse muscle stem cell aging with Prostaglandin E2

Chronic hyponatremia causes anxiety-like behaviors by disrupting brain chemistry

How Fluidics is Powering Modern Healthcare and Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

New open access tool could accelerate drug discovery

Unexpected protein production in immune cells may fuel gut inflammation

Enhanced Genomics appoints Dietrich Stephan, Ph.D. as Chair of the Board to lead ambitious growth strategy

Dr. Stephen Ross’s research into psychedelic medicine expands therapeutic frontiers

CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development

Patient-derived xenograft models may become an indispensable tool in precision oncology

Unveiling the biological frontier: CRAIC Technologies Circular Dichroism Microspectrometers pioneer molecular insights

AI-designed drug shows early promise for lung fibrosis patients in clinical trial

FDA approves ENCELTO implant to preserve sight in people with macular telangiectasia type 2

AI and human scientists collaborate to discover new cancer drug combinations

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