Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

New pipeline of drug candidates offers hope for effective MASLD treatments

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), has become the most prevalent chronic liver disease globally.

25 Sep 2024

High body roundness index linked to increased cardiovascular disease risk

Having a high body roundness index (BRI) over a 6-year period was associated with an increased risk of developing cardiovascular disease for adults older than age 45, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

25 Sep 2024

Targeted obesity programs reduce lipid-related heart disease risk in children

Researchers assess the lipid profiles of obese children and adolescents and their health implications.

24 Sep 2024

Lipid biomarkers in children with obesity linked to future cardiometabolic risks

Scientists from the University of Copenhagen have detected lipid biomarkers in children and teenagers with obesity that indicate an increased risk of developing type 2 diabetes, liver and heart disease as adults.

20 Sep 2024

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Researchers examine how different dietary components affect the gut microbiome and development of non-communicable diseases.

20 Sep 2024

Childhood adversity linked to elevated health risks, differing by sex and stress

Researchers assess the heterogeneous effects of childhood adversity on disease biomarkers and health conditions in adulthood.

20 Sep 2024

New blood test identifies obesity-related health risks in children

A new type of blood test using lipids could make it easier to identify children at risk of complications around obesity including type two diabetes, liver and heart disease, say scientists.

20 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

A study led by Manuel Vázquez Carrera, group leader at the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) at the University of Barcelona, reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease).

17 Sep 2024

SARS-CoV-2 exposure stabilizes BMI in infected adults while others see shifts

Real-world study reveals how SARS-CoV-2 infection influences body mass index, showing stable BMI in infected individuals while unexposed and pre-pandemic groups saw changes.

16 Sep 2024

Hormone therapy found to improve insulin sensitivity in menopausal women

Menopausal women are at greater risk of insulin resistance as a result of declining estrogen levels. Previous studies evaluating the potential benefits of hormone therapy on insulin resistance have produced mixed results.

16 Sep 2024

Unhealthy maternal diet may lead to heart and diabetes risks in offspring

Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.

16 Sep 2024

Ketogenic diet restores menstrual cycles and boosts fertility in women with PCOS

A ketogenic diet restored menstrual cycles in all women with PCOS in a study, with over half of those desiring pregnancy achieving it. The diet could be a promising approach to enhance fertility.

15 Sep 2024

Semaglutide and tirzepatide significantly improve weight loss and glycemic control in type 1 diabetes

Semaglutide and tirzepatide treatment lead to significant weight loss and improve blood sugar control in individuals with type 1 diabetes (T1D) who are living with overweight or obesity, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) has found.

13 Sep 2024

Endurance exercise transforms fat tissue and boosts metabolic health in adults with obesity

Regular endurance exercise significantly remodels abdominal subcutaneous fat in adults with obesity, enhancing its metabolic function and contributing to better cardiometabolic health.

11 Sep 2024

Brazilian research uncovers how liver nerves regulate glucose production under stress

A study led by Brazilian researchers has produced a detailed description of the morphology of the nerves in the liver and how they control production of glucose when the organism is under stress.

11 Sep 2024

Obesity medication liraglutide safe and effective in children under 12, research finds

The obesity medication liraglutide is safe and effective in children aged 6 to <12 years, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September), and published simultaneously in the New England Journal of Medicine (NEJM), has found.

10 Sep 2024

Estrogen-based hormone therapies have favorable long-term effects on heart disease risk

Recent studies show that women can experience bothersome menopause symptoms, like hot flashes, for longer than originally estimated.

10 Sep 2024

Night owls have higher BMI, larger waists and face higher risk of type 2 diabetes

Night owls have a higher BMI, larger waists, more hidden body fat and are almost 50% more likely to develop type 2 diabetes (T2D) than those who go to bed earlier, new research to be presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September), has found.

9 Sep 2024

Insulin Resistance News and Research

Further Reading

New pipeline of drug candidates offers hope for effective MASLD treatments

High body roundness index linked to increased cardiovascular disease risk

Targeted obesity programs reduce lipid-related heart disease risk in children

Lipid biomarkers in children with obesity linked to future cardiometabolic risks

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Childhood adversity linked to elevated health risks, differing by sex and stress

New blood test identifies obesity-related health risks in children

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

SARS-CoV-2 exposure stabilizes BMI in infected adults while others see shifts

Hormone therapy found to improve insulin sensitivity in menopausal women

Unhealthy maternal diet may lead to heart and diabetes risks in offspring

Ketogenic diet restores menstrual cycles and boosts fertility in women with PCOS

Semaglutide and tirzepatide significantly improve weight loss and glycemic control in type 1 diabetes

Endurance exercise transforms fat tissue and boosts metabolic health in adults with obesity

Brazilian research uncovers how liver nerves regulate glucose production under stress

Obesity medication liraglutide safe and effective in children under 12, research finds

Estrogen-based hormone therapies have favorable long-term effects on heart disease risk

Night owls have higher BMI, larger waists and face higher risk of type 2 diabetes

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