Metabolites News and Research

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How soy and gut microbes alter cancer treatment results

Researchers have discovered that plant-derived phytochemicals and their gut microbiome metabolites control the effectiveness of PI3K inhibitors in cancer therapy. The study reveals that dietary components, especially soy compounds processed by gut bacteria, can alter drug metabolism and impact treatment outcomes.

2 Jun 2025

Review shows how extra virgin olive oil transforms heart health

Regular consumption of extra virgin olive oil is linked to lower cardiovascular disease risk, improving heart health through its rich polyphenol content.

2 Jun 2025

Healthy food choices found to be key in reducing heart disease risk

A new study that followed almost 200,000 people for several decades has found that when it comes to heart health, the quality of food consumed matters as much as following a low-carbohydrate or low-fat diet.

1 Jun 2025

Intestinal bacteria and their metabolites contribute directly to vascular aging

The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown for the first time that intestinal bacteria and their metabolites contribute directly to vascular aging.

28 May 2025

New biomarkers could help improve detection and treatment of gastrointestinal diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

28 May 2025

Researchers develop bioactive peptide with therapeutic and regenerative potential

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising.

28 May 2025

Firmicutes bacteria can help maintain bone mass, study suggests

A recent study involving 684 Chinese adults has uncovered a significant connection between gut microbiota, aging, and bone health, particularly in relation to osteoporosis, a condition that weakens bones and increases the risk of fractures.

27 May 2025

Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicity

A recent study published in Engineering has shed light on the relationship between gut microbiota, isoflavones, and geniposide hepatotoxicity.

26 May 2025

Tufts researchers develop dental floss sensor for real time stress monitoring

Chronic stress can lead to increased blood pressure and cardiovascular disease, decreased immune function, depression, and anxiety.

23 May 2025

Machine learning tool identifies metabolic clues in colorectal cancer

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

22 May 2025

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi Minh City (Vietnam).

22 May 2025

Unlocking the secrets of human longevity and healthy aging

Human healthy aging and longevity are complex phenomena influenced by a dynamic interplay of genetic, epigenetic, metabolic, immune, and environmental factors.

22 May 2025

Blood and urine tests reveal how much ultra-processed food you really eat, study finds

Researchers developed and validated blood and urine metabolite scores that objectively measure ultra-processed food (UPF) intake in adults. These biomarker profiles accurately distinguished between high- and low-UPF diets and may transform nutrition research and public health monitoring.

21 May 2025

Exploring the link between microbial balance and aging mechanisms

Aging is a multifaceted process driven by interconnected biological mechanisms, among which genomic instability and telomere attrition stand as primary hallmarks.

20 May 2025

NIH researchers develop poly-metabolite score to measure ultra-processed food intake

For the first time, researchers at the National Institutes of Health (NIH) identified patterns of metabolites in blood and urine that can be used as an objective measure of an individual's consumption of energy from ultra-processed foods.

20 May 2025

Newly discovered Cat1 protein halts viral infections by depleting cellular fuel

Every living creature on Earth needs to protect itself from things that would do it harm. Bacteria are no different. And despite their relative simplicity, they deploy remarkably savvy defensive strategies against viral invaders.

18 May 2025

Solgate streamlines SLC drug discovery with INTEGRA's automated pipetting systems

Solgate - a biotech start-up based in Klosterneuburg, Austria - is accelerating the development of new therapies targeting solute carrier (SLC) transporters using automated liquid handling systems from INTEGRA Biosciences.

14 May 2025

Study reveals phthalate exposure harms early sexual development in children

Maternal exposure to phthalates during pregnancy is linked to shorter anogenital distance in 3-year-old boys, a marker of impaired sexual development. Girls showed similar outcomes from their own postnatal exposure, highlighting the lasting hormonal risks of environmental pollutants.

10 May 2025

Modified face mask detects chronic kidney disease through breath

Surgical face masks help prevent the spread of airborne pathogens and therefore were ubiquitous during the COVID-19 pandemic.

7 May 2025

How urine caffeine levels may help detect diabetic eye damage early

Researchers found that higher urinary levels of caffeine and specific metabolites, especially in men, were significantly associated with diabetic retinopathy risk. The cross-sectional study used NHANES 2009–2014 data and highlights potential biomarkers for early detection in diabetic populations.

7 May 2025