MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

Researchers show role for predictive biomarker in neonatal chronic lung disease pathogenesis

Extremely low birth-weight babies are at risk for a chronic lung disease called bronchopulmonary dysplasia, or BPD.

9 Mar 2018

Study reveals key function of ALS-linked protein

The protein FUS, whose mutation or disruption causes many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), works as a central component of one of the most important regulatory systems in cells, according to a new study in Molecular Cell from scientists at Johns Hopkins Bloomberg School of Public Health.

8 Mar 2018

New study shows advantages of DNA barcoding technique for identifying nanoparticles

The first direct comparison of in vitro and in vivo screening techniques for identifying nanoparticles that may be used to transport therapeutic molecules into cells shows that testing in lab dishes isn't much help in predicting which nanoparticles will successfully enter the cells of living animals.

5 Mar 2018

New discovery could help understand and treat glaucoma

Researchers have discovered two distinct groups of short molecules that regulate gene expression in the eyes of people with two different forms of glaucoma.

26 Feb 2018

Research provides new directions in understanding and fighting glaucoma

Two distinctive handfuls of short molecules that regulate gene expression have been found in the eye fluid of patients with two distinct types of vision degenerating glaucoma.

26 Feb 2018

Bioactive compound limits collateral damage in the kidneys after heart attack

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim -- the kidneys.

21 Feb 2018

Father's stress affects the brain development of offspring, mice study shows

New research in mice has found that a father's stress affects the brain development of his offspring. This stress changes the father's sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring.

19 Feb 2018

Small molecule plays huge role in keeping people safe from machinations of cancer

One small molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer, scientists report.

31 Jan 2018

Researchers uncover small molecule that plays key role in protecting against cancer

In a new study, researchers have shown that a small molecule involved in the regulation of gene expression plays an important role in protecting against cancer.

31 Jan 2018

Researchers reveal important role of estrogen in neuroblastoma

The female sex hormone estrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children.

29 Jan 2018

Researchers trace root cause of bronchiolitis symptoms

Every winter, doctors' offices and hospital emergency rooms fill with children who have bronchiolitis, an inflammation of the small airways in the lung.

25 Jan 2018

Binge drinkers have increased levels of biomarker molecule that may contribute to poor vascular function

A new study shows that binge drinkers have increased levels of a biomarker molecule - microRNA-21 - that may contribute to poor vascular function.

24 Jan 2018

Researchers discover potential target genes to halt thyroid cancer progression

Thyroid cancer is a disease with good cure rates in most cases. In 5% of patients, however, the tumor becomes refractory to the available therapies and may spread all over the body, causing death.

19 Jan 2018

Biomarkers may help predict prognosis of gastric cancer patients with alcohol consumption habits

Alcohol consumption has been identified as a modifiable risk factor for cancers such as gastric cancer. A new report in the The American Journal of Pathology sheds light on how specific proteins interact with alcohol, and how that interplay impacts survival and response to platinum-based adjuvant chemotherapy in patients with gastric cancer who may or may not still be drinking.

10 Jan 2018

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

2 Jan 2018

Discovery of potential biomarker for Huntington's disease may help postpone disease onset

A new discovery of a potential biomarker for Huntington's disease (HD) could mean a more effective way of evaluating the effectiveness of treatments for this neurological disease.

2 Jan 2018

Researchers develop nanowire device to detect urinary markers implicated in cancer

Researchers centered at Nagoya University develop a nanowire device able to detect microscopic levels of urinary markers potentially implicated in cancer.

26 Dec 2017

Researchers sequence salamander genome to reveal unique features of regeneration

Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times greater than the human genome.

22 Dec 2017

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

A new study shows that attaching antibody-like RNA nanoparticles to microvesicles can deliver effective RNA therapeutics such as small interfering RNA specifically to cancer cells.

13 Dec 2017

Tgen And Baylor secure federal grant to develop early detection system for pancreatic cancer

A group of the nation's premier cancer researchers led by the Baylor Scott & White Research Institute and the Translational Genomics Research Institute -- has secured a $5.13 million federal grant to develop an early detection system for pancreatic cancer, the nation's third-leading cause of cancer-related death.

11 Dec 2017

MicroRNA News and Research

Further Reading

Researchers show role for predictive biomarker in neonatal chronic lung disease pathogenesis

Study reveals key function of ALS-linked protein

New study shows advantages of DNA barcoding technique for identifying nanoparticles

New discovery could help understand and treat glaucoma

Research provides new directions in understanding and fighting glaucoma

Bioactive compound limits collateral damage in the kidneys after heart attack

Father's stress affects the brain development of offspring, mice study shows

Small molecule plays huge role in keeping people safe from machinations of cancer

Researchers uncover small molecule that plays key role in protecting against cancer

Researchers reveal important role of estrogen in neuroblastoma

Researchers trace root cause of bronchiolitis symptoms

Binge drinkers have increased levels of biomarker molecule that may contribute to poor vascular function

Researchers discover potential target genes to halt thyroid cancer progression

Biomarkers may help predict prognosis of gastric cancer patients with alcohol consumption habits

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

Discovery of potential biomarker for Huntington's disease may help postpone disease onset

Researchers develop nanowire device to detect urinary markers implicated in cancer

Researchers sequence salamander genome to reveal unique features of regeneration

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

Tgen And Baylor secure federal grant to develop early detection system for pancreatic cancer

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