Preclinical News and Research

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Insilico Medicine develops new deep-learning based hematological human aging clock

Today, Insilico Medicine, Inc., a Baltimore-based company specializing in the application of artificial intelligence for drug discovery, biomarker development and aging research, announced a publication of a research paper titled "Population-specific biomarkers of human aging: a big data study using South Korean, Canadian and Eastern-European patient populations" in The Journal of Gerontology.

11 Jan 2018

Stress accelerates development of pancreatic cancer, study shows

A new study shows that stress accelerates the development of pancreatic cancer by triggering the release of "fight-or-flight" hormones. Beta-blockers--commonly used medications that inhibit these hormones--were found to increase survival in a mouse model of the disease.

10 Jan 2018

CHOP researchers explore effective nutritional therapies for mitochondrial disease

Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems.

10 Jan 2018

Oncologists discover cell type that gives rise to soft tissue cancer in children

St. Jude Children's Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children.

8 Jan 2018

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

Newly described super-silenced DNA reveals novel approach to reprogram cells

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study in Molecular Cell last week by investigators from the Perelman School of Medicine at the University of Pennsylvania.

5 Jan 2018

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Disorders caused by a leaky vasculature are more common than most people think. Despite ICU treatment, one third of the 27 million patients globally that suffer from sepsis, and up to 20% of the more than 5 million US patients with congestive heart failure die every year from their condition.

5 Jan 2018

UC Davis expert expresses caution on genetically engineered HSCs

In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death during transplantation.

4 Jan 2018

Scientists discover mechanism that amplifies autoimmune reaction in early stage islet autoimmunity

Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes.

4 Jan 2018

Wake Forest Baptist receives NIH grant for alcohol addiction research center

The National Institutes of Health has awarded Wake Forest Baptist Medical Center a grant worth an estimated $8 million over five years for the establishment of a new center for research into alcohol addiction.

3 Jan 2018

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017

Probiotics may offer protection against depression linked to unhealthy lifestyle

New research suggests that the micro-organisms known as probiotics, which are normally providing health benefits in the intestines, also have an affect on the brain, or as an actual study at Aarhus University has shown; protect against depression.

22 Dec 2017

Study findings could lead to less expensive and more effective cancer treatments

The latest generation of cancer treatments spring from the discovery that the human immune system is able to beat the disease. Like Dorothy in "The Wizard of Oz," what research teams around the world have spent decades searching for was right in their own backyard all along.

20 Dec 2017

Antidepressant may also alleviate multiple sclerosis symptoms

The antidepressant clomipramine may also alleviate symptoms of multiple sclerosis (MS), specifically in its progressive form, i.e. when it occurs without relapses or remissions.

20 Dec 2017

UGR study paves way for development of better analgesics to treat joint pain

Researchers from the University of Granada have led a novel study in mice which shows that neurons mediating joint pain are different from those mediating cutaneous pain.

19 Dec 2017

Bruker Biospec MRI device installed at The Weizmann Institute of Science

The Weizmann Institute of Science in Rehovot, Israel, today announced the installation of the Biospec® 15.2 Tesla USR™ preclinical ultra-high field magnetic resonance imaging (MRI) instrument from Bruker. The new instrument is installed in the Daniel Wolf building of the Department of Chemical Research, and is used by the MRI Biosensors laboratory, led by Dr. Bar-Shir, and the laboratory of Professor Neeman, to open new frontiers in molecular and microscopic imaging, adding to the team's existing world-class MRI instruments.

From Bruker BioSpin Group 19 Dec 2017

Preclinical News and Research

Insilico Medicine develops new deep-learning based hematological human aging clock

Stress accelerates development of pancreatic cancer, study shows

CHOP researchers explore effective nutritional therapies for mitochondrial disease

Oncologists discover cell type that gives rise to soft tissue cancer in children

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Newly described super-silenced DNA reveals novel approach to reprogram cells

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

UC Davis expert expresses caution on genetically engineered HSCs

Scientists discover mechanism that amplifies autoimmune reaction in early stage islet autoimmunity

Wake Forest Baptist receives NIH grant for alcohol addiction research center

Nanobiotix receives FDA approval for first immuno-oncology trial

Probiotics may offer protection against depression linked to unhealthy lifestyle

Study findings could lead to less expensive and more effective cancer treatments

Antidepressant may also alleviate multiple sclerosis symptoms

UGR study paves way for development of better analgesics to treat joint pain

Bruker Biospec MRI device installed at The Weizmann Institute of Science

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Study: Ketamine more effective than common sedative in reducing suicidal thoughts

UQ researchers create new and improved version of ‘love hormone’

Retinal diseases could be treated by ophthalmic drops instead of intraocular injections

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