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Senolytic drugs are not a "one-size-fits-all" remedy and may benefit some older women

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a "one-size-fits-all" remedy, Mayo Clinic researchers have found.

2 Jul 2024

Modulating gene expression using small molecules

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

2 Jul 2024

Pharmacogenomics: A pathway to personalized treatment in prostate cancer

Prostate cancer (PC) stands as the second leading cause of death among American men, with about 1 in 8 men diagnosed during their lifetime.

2 Jul 2024

Study hints at a promising approach for treating wet age-related macular degeneration

A new study in mice hints at the promise of an eventual alternative treatment option for the "wet" version of age-related macular degeneration (AMD).

2 Jul 2024

Pain doesn’t belong on a scale of zero to 10

Over the past two years, a simple but baffling request has preceded most of my encounters with medical professionals: "Rate your pain on a scale of zero to 10."

2 Jul 2024

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Optibrium, a leading developer of software and AI solutions for molecular design today announced the publication of a peer-reviewed study in Journal of Computer-Aided Molecular Design, ‘From UK-2A to florylpicoxamid: Active learning to identify a mimic of a macrocyclic natural product’

From Optibrium Ltd. 2 Jul 2024

Taxing broad-spectrum antibiotics could be a strategy to combat antibiotic resistance

Taxing certain antibiotics could help efforts to tackle the escalating threat of antibiotic resistance in humans, according to a new study by the University of East Anglia's Centre for Competition Policy, Loughborough University and E.CA Economics.

1 Jul 2024

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

Antibiotic resistant bacteria are experts in evolving new strategies to avoid being killed by antibiotics.

1 Jul 2024

Suppressing a protein turns ordinary fat into a calorie burner, study shows

New UCSF study shows that suppressing a protein turns ordinary fat into a calorie burner and may explain why drug trials attempting the feat haven't been successful.

1 Jul 2024

New study reveals key to more effective antihistamines

Even if two molecules have the exact same chemical formula and the same number and types of bonds, their three-dimensional arrangements can still be different.

1 Jul 2024

Engineered E. coli optimizes targeted tumor cell killing and improves biosafety

Live bacteria can be applied in cancer therapy given their ability to deplete nutrients and induce cell death in tumors.

1 Jul 2024

Challenging the chronic brain disease model of addiction

Addiction is not simply a chronic brain disease and considering it as such can limit treatment options and increase stigma, an extensive research review suggests.

1 Jul 2024

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.

1 Jul 2024

Natural compound found in olives can lower blood sugar levels and promote weight loss

Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss.

29 Jun 2024

Innovative dementia cost model to aid families and shape health policy

An A-list of researchers from across USC is building a dementia cost model that will generate comprehensive national, annual estimates of the cost of dementia that could benefit patients and their families, thanks to a five-year, $8.2 million federal grant from the National Institute on Aging.

28 Jun 2024

Loss of salt, body fluid can stimulate kidney regeneration and repair in mice

A loss of salt and body fluid can stimulate kidney regeneration and repair in mice, according to a NIH-funded study led by USC Stem Cell scientist Janos Peti-Peterdi and published in The Journal of Clinical Investigation.

28 Jun 2024

KFF Health News' 'What the Health?': SCOTUS ruling strips power from federal health agencies

In what will certainly be remembered as a landmark decision, the Supreme Court's conservative majority this week overruled a 40-year-old legal precedent that required judges in most cases to yield to the expertise of federal agencies.

28 Jun 2024

New method developed to map mechanistic connections between diseases

Tampere University researchers developed a method to map mechanistic connections between diseases, revealing deeper associations beyond traditional classifications based on affected organs and symptoms.

28 Jun 2024

Live biotherapeutic product can improve clinical outcomes for patients with kidney cancer

Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes.

28 Jun 2024

New research may help explain recurrent Crohn's disease in children

Remarkable new research by a University of Virginia undergraduate may help explain recurrent Crohn's disease in children and open the door to new ways to treat or even cure the devastating condition.

28 Jun 2024

Drugs News and Research

Senolytic drugs are not a "one-size-fits-all" remedy and may benefit some older women

Modulating gene expression using small molecules

Pharmacogenomics: A pathway to personalized treatment in prostate cancer

Study hints at a promising approach for treating wet age-related macular degeneration

Pain doesn’t belong on a scale of zero to 10

Optibrium demonstrates accelerated lead optimization in complex agrochemical development

Taxing broad-spectrum antibiotics could be a strategy to combat antibiotic resistance

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

Suppressing a protein turns ordinary fat into a calorie burner, study shows

New study reveals key to more effective antihistamines

Engineered E. coli optimizes targeted tumor cell killing and improves biosafety

Challenging the chronic brain disease model of addiction

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Natural compound found in olives can lower blood sugar levels and promote weight loss

Innovative dementia cost model to aid families and shape health policy

Loss of salt, body fluid can stimulate kidney regeneration and repair in mice

KFF Health News' 'What the Health?': SCOTUS ruling strips power from federal health agencies

New method developed to map mechanistic connections between diseases

Live biotherapeutic product can improve clinical outcomes for patients with kidney cancer

New research may help explain recurrent Crohn's disease in children

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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