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Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

New research from Queen Mary University of London, published in Nature Medicine, has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug treatments will work to treat rheumatoid arthritis (RA) patients.

19 May 2022

Should children be vaccinated against COVID-19?

A new study conducted examines issues surrounding children between the ages of five and 11 who are eligible for vaccination against SARS-CoV-2.

18 May 2022

New weight-loss intervention focuses on improving a person’s response to hunger cues

People who are highly responsive to food lost more weight and, importantly, were more successful at keeping the pounds off using a new alternative weight-loss intervention that targets improving a person's response to internal hunger cues and their ability to resist food, reported a team led by University of California San Diego experts in the May 18, 2022 online issue of JAMA Network Open.

18 May 2022

STOP-COVID19 trial: Brensocatib did not improve clinical status of patients with severe SARS-CoV-2 infection

Brensocatib did not improve the clinical status of patients hospitalized with severe SARS-CoV-2 infection in the double-blind randomized, placebo-controlled STOP-COVID19 multicenter clinical trial, according to research published at the ATS 2022 international conference.

18 May 2022

Insight into sustained-release drug delivery systems

In this interview, News-Medical speaks to Thanh T. Nguyen, a project manager at Innocore Pharmaceuticals, about the mechanisms behind long-acting injectables.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 18 May 2022

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Imugene Limited, a clinical stage immuno-oncology company, and City of Hope, one of the largest cancer research and treatment organizations in the United States, today announced that the first patient was dosed in a Phase 1 clinical trial evaluating the safety of novel cancer-killing virus CF33-hNIS VAXINIA when used in people with advanced solid tumors.

18 May 2022

Cannabidiol for Parkinson's disease symptom management

Scientists have published a review study in the Journal for Nurse Practitioners that has focussed on various aspects of the use of cannabidiol in Parkinson's.

17 May 2022

Polypharmacy can lead to harmful drug interactions, especially among cancer patients

Here's a scenario so common that it applies to nearly 92 percent of older adults with cancer: An individual comes in for treatment and reports taking several medications that might include a drug for high blood pressure or heart disease, an antidepressant, or something for diabetes.

17 May 2022

Experimental drug more effective than existing FDA-approved medications for ALS

New research on the experimental drug, NU-9, invented and developed by two Northwestern University scientists to treat ALS (amyotrophic lateral sclerosis), shows it is more effective than existing FDA-approved drugs for the disease.

17 May 2022

Multi-country study provides a clear treatment option for IgA nephropathy

The largest ever randomized controlled trial in IgA nephropathy has found that treatment with methylprednisolone - a cheap, widely used corticosteroid drug - halves the risk of losing kidney function and kidney failure, and that this can be effectively achieved with fewer side effects if a reduced dose is used.

17 May 2022

Less invasive procedure for common heart condition just as effective as conventional open-heart surgery

A study led by researchers at the National Institute for Health and Care Research Leicester Biomedical Research Centre has shown that a less invasive heart procedure for a common condition is just as effective as conventional open-heart surgery.

17 May 2022

Study: Daily intake of Urolithin A improves muscle strength by 12% after four months

Age-associated muscle decline can start as early as 40 years old and there are currently no effective interventions to counteract it other than exercise.

17 May 2022

Ultra-high strength 7T MRI scanner offers hope for treating cognitive symptoms in Parkinson’s patients

Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson's disease and similar conditions most likely to benefit from new treatments for previously-untreatable symptoms, say scientists.

17 May 2022

Scientists use machine learning techniques for better characterization of long COVID

A research team supported by the National Institutes of Health has identified characteristics of people with long COVID and those likely to have it.

16 May 2022

New imaging probe illuminates breast cancer cells to optimize tumor removal

Nearly 13 percent of women born in the U.S. today will develop breast cancer at some point during their lives.

16 May 2022

Immunotherapy combined with chemoradiation and surgery could help treat nonmetastatic gastroesophageal cancer

Immunotherapy has transformed treatment for patients with stage 4 metastatic esophageal and gastric cancers. In patients with these malignancies, immunotherapy has been shown to prolong survival when patients' tumors exhibit a high expression of an immune-related protein called PD-L1.

16 May 2022

Robotic surgery reduces readmissions, benefits patients' overall recovery

A new study, published in JAMA, has found that robotic surgery reduces the chance of readmission by half (52 per cent), and revealed a "striking" four-fold (77 per cent) reduction in prevalence of blood clots (deep vein thrombus and pulmonary emboli) - a significant cause of health decline and morbidity - when compared to patients who had open surgery.

15 May 2022

Immunotherapy after bladder cancer surgery helps reduce cancer recurrence

Immunotherapy after surgery helped reduce cancer recurrence in patients with urothelial cancer of the bladder or other sites in the urinary tract that had invaded the muscle and therefore posed a high risk for recurrence, according to clinical trial results presented at the American Urological Association annual meeting in May.

15 May 2022

Novel approach allows islet transplants to survive and control diabetes

In type 1 diabetes, an autoimmune response attacks the pancreas's insulin-producing beta cells, leading to marked fluctuations in blood sugar levels. Lifelong daily insulin treatments are standard for patients, but replacing lost beta cells through transplants of islets, a group of cells in the pancreas, represents an attractive option.

13 May 2022

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

Islet cell transplants are a promising treatment that can cure difficult-to-treat type 1 diabetes. The cells, taken from a donor pancreas, provide patients with a sustainable and tightly controlled source of insulin.

13 May 2022

Clinical Trial News and Research

Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patients

Should children be vaccinated against COVID-19?

New weight-loss intervention focuses on improving a person’s response to hunger cues

STOP-COVID19 trial: Brensocatib did not improve clinical status of patients with severe SARS-CoV-2 infection

Insight into sustained-release drug delivery systems

First patient dosed in Phase 1 clinical trial evaluating the safety of CF33-hNIS against solid tumors

Cannabidiol for Parkinson's disease symptom management

Polypharmacy can lead to harmful drug interactions, especially among cancer patients

Experimental drug more effective than existing FDA-approved medications for ALS

Multi-country study provides a clear treatment option for IgA nephropathy

Less invasive procedure for common heart condition just as effective as conventional open-heart surgery

Study: Daily intake of Urolithin A improves muscle strength by 12% after four months

Ultra-high strength 7T MRI scanner offers hope for treating cognitive symptoms in Parkinson’s patients

Scientists use machine learning techniques for better characterization of long COVID

New imaging probe illuminates breast cancer cells to optimize tumor removal

Immunotherapy combined with chemoradiation and surgery could help treat nonmetastatic gastroesophageal cancer

Robotic surgery reduces readmissions, benefits patients' overall recovery

Immunotherapy after bladder cancer surgery helps reduce cancer recurrence

Novel approach allows islet transplants to survive and control diabetes

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

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