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Supercomputer simulations lead to an important viral inhibitor discovery

University of New Hampshire researchers recently used Comet at the San Diego Supercomputer Center at UC San Diego and Stampede2 at the Texas Advanced Computing Center to identify new inhibitor binding/unbinding pathways in an RNA-based virus.

17 Dec 2020

New technology tested for removing, destroying hazardous chemicals from soil and groundwater

University of Rhode Island hydrogeologist Thomas Boving and colleagues at EnChem Engineering Inc. are testing a proprietary new technology for quickly removing and destroying hazardous chemical compounds from soil and groundwater.

17 Dec 2020

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

For a vaccine to be most effective, sometimes nature needs a little 'extra' something. That something is often an adjuvant -- small molecules added to a vaccine that boost the body's immune response.

17 Dec 2020

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Positive results from additional analyses of PRIDE-HD and Open-HART trials with pridopidine published in a peer-reviewed journal, The Journal of Huntington's Disease.

17 Dec 2020

Specific genetic target could help explain the variation in COVID-19 effects

The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has identified a specific genetic target that could help explain the tremendous variation in how sick those infected with COVID-19 become.

17 Dec 2020

Scientists demonstrate a promising strategy for treating lymphomas

Scientists at Scripps Research have demonstrated a promising new strategy for treating lymphomas, a group of cancers that begin in infection-fighting cells of the immune system called lymphocytes.

16 Dec 2020

Oral hormone therapy significantly alters the metabolome of postmenopausal women

Groundbreaking research led by a team of scientists including a University of Massachusetts Amherst biostatistician shows that oral hormone therapy (HT) significantly alters the metabolome of postmenopausal women.

16 Dec 2020

New screening platform can be used to discover more effective drugs for type 1 diabetes

With nearly 2 million Americans battling type 1 diabetes, it is no surprise that clinical therapies for the disease are constantly evolving and improving.

16 Dec 2020

Regulating a protein channel responsible for transporting chloride across cell membranes

Laboratory cell experiments and computer simulations have revealed molecular mechanisms regulating a protein channel responsible for transporting chloride and other charged molecules across cell membranes.

16 Dec 2020

Researchers design new chemical tool with high configurational stability, catalytic activity

Researchers have designed and built a new chemical tool inspired by natural metal-containing enzymes in living organisms. The product, a tetrahedral "chiral zinc", maintains its shape for years, providing a new structure with exciting possibilities for manufacturing pharmaceuticals and optical electronics.

15 Dec 2020

Novel MRI contrast agent shows strong potential as safer alternative to current products

Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image quality and allows radiologists who interpret MRI scans to pick up subtle anatomic details and abnormalities that might otherwise be missed.

15 Dec 2020

New class of targeted cancer drugs may prove effective in treating common types of leukemia

A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia.

15 Dec 2020

New tool aids in the discovery of RNA medicines for undruggable diseases

Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some "undruggable" diseases, including a type of metastatic breast cancer.

15 Dec 2020

Study offers new clues to the pathogenesis of glaucoma

In the search for new ways to treat the incurable eye disease glaucoma, researchers at Karolinska Institutet and St. Erik Eye Hospital in Sweden have discovered more clues as to its pathogenesis.

15 Dec 2020

Scientists empower wireless sensors with vision abilities to fight viruses

Current and former early-career scientists share their stories and tell how Europe has bet on them, making their high-risk research possible: from intelligent wireless sensors with vision abilities to RNA-based techniques to fight viruses, from the mathematical formulas of the MRI waves to optoceutics, the new technique that uses light to repair the heart after a stroke.

15 Dec 2020

Landmark heart study reveals new insights about risk factors for depression

Recently published UT Southwestern research reveals new insights about risk factors for depression based on data from a landmark longitudinal study focused on heart disease.

14 Dec 2020

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

A new study published in the pre-print server bioRxiv* explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its inhibitors. T

14 Dec 2020

Study shows how STAT5 optimizes function of CD4+ T cells to drive antitumor immunity

Cancer immunotherapy using "designer" immune cells has revolutionized cancer treatment in recent years. In this type of therapy, T cells, a type of white blood cell, are collected from a patient's blood and subjected to genetic engineering to produce T cells carrying a synthetic molecule termed chimeric antigen receptor (CAR) that is designed to enable T cells to recognize and destroy cancer cells.

14 Dec 2020

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

According to the results of research led by the Complutense University of Madrid (UCM), one the various strategies deployed by the Leishmania parasite to avoid triggering the human immune system is to activate the SHP-1 protein.

11 Dec 2020

Molecule News and Research

Supercomputer simulations lead to an important viral inhibitor discovery

New technology tested for removing, destroying hazardous chemicals from soil and groundwater

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

Additional data demonstrates positive results of pridopidine drug on Total Functional Capacity

Specific genetic target could help explain the variation in COVID-19 effects

Scientists demonstrate a promising strategy for treating lymphomas

Oral hormone therapy significantly alters the metabolome of postmenopausal women

New screening platform can be used to discover more effective drugs for type 1 diabetes

Regulating a protein channel responsible for transporting chloride across cell membranes

Researchers design new chemical tool with high configurational stability, catalytic activity

Novel MRI contrast agent shows strong potential as safer alternative to current products

New class of targeted cancer drugs may prove effective in treating common types of leukemia

New tool aids in the discovery of RNA medicines for undruggable diseases

Study offers new clues to the pathogenesis of glaucoma

Scientists empower wireless sensors with vision abilities to fight viruses

Landmark heart study reveals new insights about risk factors for depression

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

Study shows how STAT5 optimizes function of CD4+ T cells to drive antitumor immunity

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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