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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Scientists unravel longstanding mystery of fundamental property of the brain

In new research published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS), a team of scientists from the Hebrew University Hadassah Medical School, in the Faculty of Medicine, unraveled a longstanding mystery of a fundamental property of the brain.

24 Dec 2015

Dynamic light scattering technique may help detect people at risk of cataracts and presbyopia

As we age, proteins in the lenses of our eyes start misbehaving: They unfold and congregate in clusters that block, scatter and distort light as it passes through the lens. A cloudy area, or cataract, forms. In a new study, scientists found that throughout our lifetime, levels of a key protein decline, and may be an early warning sign of a developing cataract.

23 Dec 2015

Researchers, patients trade new insights at International Dementia with Lewy Bodies Conference

You thought Alzheimer's was complicated? Or Parkinson's? Try dementia with Lewy bodies, the disease occupying the awkward territory between those two poles.

23 Dec 2015

Study shows more patients with advanced NSCLC may benefit from pembrolizumab

More patients with advanced non-small-cell lung cancer (NSCLC) could benefit from pembrolizumab, says Professor Roy Herbst, Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, presenting promising results from the pivotal phase 2/3 KEYNOTE-010 trial at the first ESMO Asia Congress in Singapore), in conjunction with a publication in The Lancet.

22 Dec 2015

Small airway-on-a-chip enables analysis of human COPD and asthma

A research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University leveraged its organ-on-a-chip technology to develop a model of the human small airway in which lung inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), the third leading cause of mortality worldwide, and asthma can be studied outside the human body.

22 Dec 2015

Adaptimmune begins Phase I/II study of affinity enhanced T-cell therapy targeting MAGE-A10 in NSCLC patients

Adaptimmune Therapeutics plc, a leader in the use of TCR engineered T-cell therapy to treat cancer, today announced that it has initiated a Phase I/II study of its affinity enhanced T-cell therapy targeting the MAGE-A10 cancer antigen in patients with locally advanced or metastatic (Stage IIIb or IV) non-small cell lung cancer (NSCLC), the most prevalent type of lung cancer representing approximately 85 percent of lung cancers.

21 Dec 2015

Novel strategies on the way for difficult-to-treat head and neck cancer

Novel strategies are on the way for difficult-to-treat and advanced head and neck cancer, the most heterogeneous group of malignancies which are generally associated with poor survival, and encouraging results have been presented at the first ESMO Asia 2015 Congress in Singapore.

17 Dec 2015

Mitochondrial variation and viable pregnancy: an interview with Dr Elpida Fragouli

Embryos require adequate amounts of energy so that they can successfully progress through each of their cell divisions.

16 Dec 2015

Molecular signatures can predict flu vaccine responses in young and old

What factors inhibit strong responses to seasonal flu vaccines in the elderly? Why do anti-flu antibodies last longer after vaccination in some people? Answers are emerging from an Emory University-based systems biology analysis of blood samples from more than 400 volunteers who received seasonal flu vaccines. Bali Pulendran, PhD, led a team of researchers who tracked patterns of gene expression, known as molecular signatures, of strong immune responses in volunteers' blood across five consecutive seasons from 2007 to 2011.

16 Dec 2015

Can Nanostructured Microelectrodes be Used to Analyze Biomarkers? An Interview with Dr Shana Kelley

Electrochemical methods are appealing because simple and inexpensive instrumentation can be used to make highly sensitive measurements. However, it has been quite difficult to realize clinically-relevant levels of sensitivity using electrochemistry in highly complex, real-world samples.

From Pittcon 15 Dec 2015

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

Premenopausal women whose invasive breast cancers were of the luminal A subtype had comparable 10-year disease-free survival rates regardless of whether or not they received adjuvant chemotherapy, according to data from the phase III DBCG77B clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

11 Dec 2015

NeuroQuest to start U.S. clinical validation trials of blood test for early diagnosis of Alzheimer's disease

NeuroQuest Development Center, Inc., today announced they have entered into a service agreement with the University of California, San Diego for collection and processing of blood samples for their U.S. clinical validation trials.

10 Dec 2015

Biotypes can identify distinct subgroups of psychosis

Three biomarker-based categories, called biotypes, outperformed traditional diagnoses, such as schizophrenia and bipolar disorder with psychosis, in sorting psychosis cases into distinct subgroups on the basis of brain biology, report researchers funded by the National Institutes of Health.

9 Dec 2015

Groundbreaking study establishes empirical biomarkers to aid in diagnosis, treatment of psychosis

In a groundbreaking study led by UT Southwestern Medical Center, a comprehensive set of empirical biomarkers has been established to aid in diagnosis and treatment of psychosis.

9 Dec 2015

UC San Diego researchers awarded MJFF grant to identify biomarkers for Parkinson's disease

Parkinson's disease is difficult to diagnose, particularly in its early stages. Now, researchers at University of California, San Diego School of Medicine - aided by a $375,000 grant from The Michael J. Fox Foundation for Parkinson's Research - hope to improve the prospects of early diagnosis by identifying a biological signpost in the blood.

9 Dec 2015

Researchers reveal potential for exploring new treatment options for triple-negative breast cancer

Researchers from Caris Life Sciences and Fox Chase Cancer Center – Temple Health announced the presentation of two studies revealing the potential for exploring new therapeutic options for triple-negative breast cancer (TNBC) at the 2015 San Antonio Breast Cancer Symposium.

7 Dec 2015

EKF biomarker identifies likely development of Diabetic Nephropathy

EKF, announces new data presented in support of soluble Tumour Necrosis Factor Receptor 1 as a biomarker to predict progression of Diabetic Nephropathy.

From EKF Diagnostics 2 Dec 2015

New device can help diagnose stroke in less than 10 minutes

Minutes count when treating stroke, but current diagnostics take as long as three hours, careful lab work and skilled technicians to arrive at a conclusive diagnosis. Scientists at Cornell University's Baker Institute for Animal Health have developed a device that helps diagnose stroke in less than 10 minutes using a drop of blood barely big enough to moisten your fingertip.

1 Dec 2015

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Researchers at the Translational Genomics Research Institute and Barrow Neurological Institute have for the first time identified genetic risk factors that are linked to stress-induced cardiomyopathy (SIC), a rare type of heart disease.

1 Dec 2015

Human Longevity announces acquisition of Cypher Genomics

Human Longevity, Inc., the genomics-based, technology-driven company, announced today that the company has acquired Cypher Genomics, Inc., a leading genome informatics company offering highly accurate, rapid and robust human genomic interpretation software solutions.

30 Nov 2015

Biomarker News and Research

Further Reading

Scientists unravel longstanding mystery of fundamental property of the brain

Dynamic light scattering technique may help detect people at risk of cataracts and presbyopia

Researchers, patients trade new insights at International Dementia with Lewy Bodies Conference

Study shows more patients with advanced NSCLC may benefit from pembrolizumab

Small airway-on-a-chip enables analysis of human COPD and asthma

Adaptimmune begins Phase I/II study of affinity enhanced T-cell therapy targeting MAGE-A10 in NSCLC patients

Novel strategies on the way for difficult-to-treat head and neck cancer

Mitochondrial variation and viable pregnancy: an interview with Dr Elpida Fragouli

Molecular signatures can predict flu vaccine responses in young and old

Can Nanostructured Microelectrodes be Used to Analyze Biomarkers? An Interview with Dr Shana Kelley

Adjuvant chemotherapy not beneficial for patients with luminal A subtype of breast cancer

NeuroQuest to start U.S. clinical validation trials of blood test for early diagnosis of Alzheimer's disease

Biotypes can identify distinct subgroups of psychosis

Groundbreaking study establishes empirical biomarkers to aid in diagnosis, treatment of psychosis

UC San Diego researchers awarded MJFF grant to identify biomarkers for Parkinson's disease

Researchers reveal potential for exploring new treatment options for triple-negative breast cancer

EKF biomarker identifies likely development of Diabetic Nephropathy

New device can help diagnose stroke in less than 10 minutes

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Human Longevity announces acquisition of Cypher Genomics

Event guide: 16th Clinical Biomarkers & CDx Summit Europe eBook

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