Therapeutics News and Research

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Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

16 Aug 2021

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job.

16 Aug 2021

Penn researchers reveal complex details of T-cell responses to mRNA COVID-19 vaccines

Messenger-RNA (mRNA) vaccines against the coronavirus that causes COVID-19 provoke a swift and strong response by the immune system's T cells - the heavy armor of the immune system - according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

16 Aug 2021

Removal of race from kidney function estimates may negatively impact care for Black cancer patients

An accurate assessment of a patient's kidney function is critical for determining eligibility for anticancer treatments.

14 Aug 2021

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer's-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

13 Aug 2021

Study: 90% of children with ADHD continue to experience residual symptoms into young adulthood

Most children diagnosed with attention deficit hyperactive disorder (ADHD) don't outgrow the disorder, as widely thought.

13 Aug 2021

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

A new study published in the journal Nature Communications has reported two neutralizing antibodies, namely, nCoVmab1 and nCoVmab2, which are potent against SARS-CoV-2.

13 Aug 2021

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

Recent progress in developing and testing plant-made vaccines has revived interest in plant-produced pharmaceuticals, including edible drugs, for human use. Advances in technology and manufacturing could boost the uptake of therapeutics made in this way, say Hugues Fausther-Bovendo and Gary Kobinger in this Perspective.

13 Aug 2021

Researchers develop silica nanostructure for selective synthesis of enantiomers in cells

As COVID-19 vaccinations are well underway, people await a return to normal life. However, fears also grow due to unforeseen side effects like rare thrombosis. In the body, life is maintained by the movement of substances or energy.

13 Aug 2021

Research debunks myth that COVID vaccination promotes mutations

A study conducted by researchers at the University of Maryland, USA, has highlighted the importance of coronavirus disease 2019 (COVID-19) vaccination in reducing the frequency of mutations in the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2021

Optical nanoscopy reveals how SARS-CoV-2 infection alters human airway cells

How do viruses reorganize host cells with spatial and molecular specificity? Researchers from the Netherlands provided new insights in a recent study posted to the bioRxiv* preprint server, where they use optical nanoscopy to look at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-triggered changes in primary human airway cells.

12 Aug 2021

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Researchers from the University of Southern California, Merck & Co., Skoltech, MIPT, UCLA, and the Université de Sherbrooke have determined the structure of the human leukotriene B4 receptor 1, involved in inflammatory, infectious, allergic, and tumorigenic diseases.

12 Aug 2021

Nanotechnology may help improve treatment for colorectal cancer and melanoma

University of Arizona Health Sciences researchers recently completed a study that has the potential to improve cancer treatment for colorectal cancer and melanoma by using nanotechnology to deliver chemotherapy in a way that makes it more effective against aggressive tumors.

12 Aug 2021

National academies’ report took pharma-friendly stance after millions in gifts from drugmakers

To several U.S. senators, it looked wasteful, even outrageous. Every year, taxpayers pay for at least $750 million worth of expensive pharmaceuticals that are simply thrown away. Companies ship many of the drugs in "Costco"-size vials, one lawmaker said, that once opened usually cannot be resealed or saved for other patients. Yet pharma gets paid for every drop.

12 Aug 2021

A new promising target for broad-spectrum therapeutics against coronaviruses

A recent study by Canadian and US researchers demonstrates how frameshift signals of coronaviruses represent a viable target for developing novel therapeutics with broad-spectrum activity – not only against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also other constituents of the coronavirus family. The study is currently available on the bioRxiv* preprint server while it undergoes peer review.

11 Aug 2021

Therapeutics News and Research

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Penn researchers reveal complex details of T-cell responses to mRNA COVID-19 vaccines

Removal of race from kidney function estimates may negatively impact care for Black cancer patients

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

Study: 90% of children with ADHD continue to experience residual symptoms into young adulthood

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

Advances in plant-made vaccines revive interest in plant-produced pharmaceuticals and edible drugs

Researchers develop silica nanostructure for selective synthesis of enantiomers in cells

Research debunks myth that COVID vaccination promotes mutations

Optical nanoscopy reveals how SARS-CoV-2 infection alters human airway cells

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Nanotechnology may help improve treatment for colorectal cancer and melanoma

National academies’ report took pharma-friendly stance after millions in gifts from drugmakers

A new promising target for broad-spectrum therapeutics against coronaviruses

Study defines SARS-CoV-2 antibodies associated with neutralization and effector functions

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

Penn study discovers a targetable vulnerability in clear cell renal cell carcinoma

Surgeons cash in on stakes in private medical device companies

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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