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New strategy to create a cheap and rapid COVID-19 test based on isothermal amplification

Russian researchers have developed a strategy to create a cheap and rapid COVID-19 test based on isothermal amplification. According to their publication in Applied Biochemistry and Microbiology, use of this strategy will make it possible to create universal test systems for any of the COVID-19 variants.

29 Dec 2021

New study targets the methylation profile of microglia from human brain

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states.

29 Dec 2021

Excessive intake of simple sugar in adolescents could be a risk factor of psychiatric disorders

There has been a remarkable increase in intake of simple sugar (sucrose, isomerized sugar (corn syrup)) from beverages and diets in modern society. The intake of simple sugars in adolescents in which mental disorders frequently occur is higher than any other generations.

28 Dec 2021

APOE4 allele gene linked to increased risk of severe COVID-19

A study conducted at the University of Helsinki and the Helsinki University Hospital suggests that the APOE4 allele may also increase cerebral microhemorrhages related to COVID-19 and associate with mental fatigue related to long COVID.

27 Dec 2021

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

Scientists at the La Jolla Institute for Immunology have uncovered how loss of TET enzymes can lead to B cell lymphoma. Their research, published in Nature Immunology, could potentially open opportunities for designing drug treatment strategies to target malignant cells in many cancers.

24 Dec 2021

Strains - not species - of gut bacteria may provide better insights into the microbiome

Every day, the billions of bacteria that inhabit your digestive system change; the food you eat, medications you take, and germs you're exposed to make some bacteria flourish more than others.

24 Dec 2021

New study provides a mutational analysis of SARS-CoV-2

A new study investigates mutational waves in structural and non-structural protein evolutions of SARS-CoV-2 to better understand the virus’s evolution and epidemiology.

24 Dec 2021

Are our bowel habits written in our DNA?

In this interview, News-Medical talks to Dr. Mauro D’Amato about how there could be clues about the regularity of bowel movements within our genes.

24 Dec 2021

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.

23 Dec 2021

Impact of the rapid spread of the SARS-CoV-2 Omicron variant in Southern Africa

A new study has focused on the genomic profile and early transmission dynamics of Omicron. This study revealed the dominance of the Omicron variant in regions with high levels of population immunity.

23 Dec 2021

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

How the SARS-CoV-2 Delta variant grew to dominate the UK epidemic

Researchers examine SARS-CoV-2 genomes in England to evaluate the effectiveness of COVID-19 policies.

22 Dec 2021

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

A newly discovered species of antibiotic-resistant bacteria has been named after the academic institute where it was identified – the John Innes Centre.

22 Dec 2021

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Researchers have experimentally proved that virus-related double-stranded RNA (dsRNA) and the sites of viral RNA synthesis are associated with one another.

22 Dec 2021

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell's nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the nucleus, which is necessary for the production of new viruses.

22 Dec 2021

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Wilmot Cancer Institute researchers are a step closer to understanding the complex gene interactions that cause a cell to become malignant.

21 Dec 2021

Promising new drug target for TB identified

Mycobacterium tuberculosis (Mtb), the hardy bacterial species that causes tuberculosis (TB), has an unexpected vulnerability that future drugs may be able to exploit, according to a study from researchers at Weill Cornell Medicine.

21 Dec 2021

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

A new study aimed to detect the genomic material of SARS-CoV-2 and its variants, such as the recently emerged variant of concern (VOC) Omicron.

21 Dec 2021

Cheap and accessible methods for genome sequencing will help tackle future pandemics

A worldwide consortium of scientists, led by the Earlham Institute and the University of Liverpool in the UK, mark a significant milestone in equipping researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens - at a cost of less than $10USD per genome.

21 Dec 2021

New oral pill for COVID-19 home treatment

As cases and hospitalizations continue to rise in many countries, new treatments are being sought to arrest the progression of the disease, preventing severe illness and death or disability. One such is the small molecule molnupiravir, the focus of a new research paper.

20 Dec 2021

Genome News and Research

New strategy to create a cheap and rapid COVID-19 test based on isothermal amplification

New study targets the methylation profile of microglia from human brain

Excessive intake of simple sugar in adolescents could be a risk factor of psychiatric disorders

APOE4 allele gene linked to increased risk of severe COVID-19

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

Strains - not species - of gut bacteria may provide better insights into the microbiome

New study provides a mutational analysis of SARS-CoV-2

Are our bowel habits written in our DNA?

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Impact of the rapid spread of the SARS-CoV-2 Omicron variant in Southern Africa

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

How the SARS-CoV-2 Delta variant grew to dominate the UK epidemic

Newly discovered species of Enterococcus bacteria named after the John Innes Centre

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Researchers identify new mechanism for DNA invasion of adenoviral COVID-19 vaccines

Researchers use network modeling to hone in on cancer gene interactions critical to malignancy

Promising new drug target for TB identified

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

Cheap and accessible methods for genome sequencing will help tackle future pandemics

New oral pill for COVID-19 home treatment

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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