Preclinical News and Research

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Researchers develop new approach to efficiently produce versatile antibody therapies

A group of researchers has developed an approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in the field of cancer immunotherapy.

29 Aug 2017

Boosting blood levels of bone-derived hormone may reverse age-related memory loss

Age-related memory loss may be reversed by boosting blood levels of osteocalcin, a hormone produced by bone cells, according to mouse studies led by Columbia University Medical Center researchers.

29 Aug 2017

SBP scientist receives DoD award to identify new and efficacious treatments for pancreatic cancer

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that the Department of Defense (DoD) has awarded Cosimo Commisso, Ph.D., a Career Development Award to identify new and efficacious treatments for pancreatic cancer.

29 Aug 2017

Research reveals LEGO-like stacking of protein complexes

When hemoglobin undergoes just one mutation, the protein complexes stick to one another, stacking like LEGO blocks to form long, stiff filaments.

29 Aug 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

Scientists from UCLA and the Howard Hughes Medical Institute successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia.

26 Aug 2017

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

26 Aug 2017

Scientists develop new chimeric antibody to treat malignant cancers in dogs

Scientists have developed a new chimeric antibody that suppresses malignant cancers in dogs, showing promise for safe and effective treatment of intractable cancers.

26 Aug 2017

Tumor irradiation may prolong survival of NSCLC patients undergoing novel chemotherapy formulation

Patients with unresectable, or inoperable, lung cancer are often given a dismal prognosis, with low rates of survival beyond a few years.

26 Aug 2017

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer, providing the potential for much needed new therapies for women with limited options.

24 Aug 2017

Scientists identify key compound that reduces severity of AMD in preclinical model

A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers.

22 Aug 2017

MUSC researchers show how non-coding RNA promotes tumor formation

A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina in an article published online ahead of print on August 21, 2017 by Nature Cell Biology.

22 Aug 2017

Novel mussel-inspired glue could one day save lives of youngest patients

Whether to perform surgery on a fetus is a heart-wrenching decision. This type of surgery involves penetrating the highly delicate amniotic sac, increasing health risks to the fetus.

21 Aug 2017

Preclinical research using 1 Tesla desktop MRI

An interview with Dr. Ichio Aoki, National Institutes for Quantum and Radiological Science and Technology.

From Bruker BioSpin Group 17 Aug 2017

Sanford Health launches solid tumor oncolytic virus clinical trial

Sanford Health is the first site in the United States to launch a clinical trial using a genetically-engineered virus that aims to destroy therapy-resistant tumors.

17 Aug 2017

Scientists reveal engineered fusion protein that could recover blood vessel health

Scientists from Boston Children's Hospital Vascular Biology Program have revealed an engineered fusion protein that could recover blood vessel health following the onset of hypertension, atherosclerosis, stroke, heart attack, and other cardiovascular diseases.

16 Aug 2017

ICP monitoring does not improve favorable outcome rate in patients with severe TBI, study shows

A new study has shown that use of intracranial pressure (ICP) monitoring in patients with severe traumatic brain injury (TBI) was associated with a significant decrease in mortality, but it did not improve the rate of favorable outcomes.

16 Aug 2017

BMG LABTECH develop world's first gas ramping function to mimic in vitro ischaemia/reperfusion conditions in a microplate reader

BMG LABTECH developed a new gas ramping function that can fully manipulate the environment within a microplate reader, by mimicking in vitro hypoxia and ischaemia/reperfusion.

From BMG LABTECH GmbH 16 Aug 2017

Researchers hint at experimental molecular treatment for heart failure

Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.

14 Aug 2017

Researchers develop new technique to locate pathogenic mutations in dark, non-coding genome

When doctors can't find a diagnosis for patient's disease, they turn to genetic detectives. Equipped with genomic sequencing technologies available for less than 10 years, these sleuths now routinely search through a patient's DNA looking for mutations responsible for mysterious diseases.

11 Aug 2017

Preclinical News and Research

Researchers develop new approach to efficiently produce versatile antibody therapies

Boosting blood levels of bone-derived hormone may reverse age-related memory loss

SBP scientist receives DoD award to identify new and efficacious treatments for pancreatic cancer

Research reveals LEGO-like stacking of protein complexes

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Junk genes could one day offer framework for treating people with familial hypercholesterolemia

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

Scientists develop new chimeric antibody to treat malignant cancers in dogs

Tumor irradiation may prolong survival of NSCLC patients undergoing novel chemotherapy formulation

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

Scientists identify key compound that reduces severity of AMD in preclinical model

MUSC researchers show how non-coding RNA promotes tumor formation

Novel mussel-inspired glue could one day save lives of youngest patients

Preclinical research using 1 Tesla desktop MRI

Sanford Health launches solid tumor oncolytic virus clinical trial

Scientists reveal engineered fusion protein that could recover blood vessel health

ICP monitoring does not improve favorable outcome rate in patients with severe TBI, study shows

BMG LABTECH develop world's first gas ramping function to mimic in vitro ischaemia/reperfusion conditions in a microplate reader

Researchers hint at experimental molecular treatment for heart failure

Researchers develop new technique to locate pathogenic mutations in dark, non-coding genome

Event guide: 4th LNP Formulation & Process Development Summit eBook

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