Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

By comparing variations in protein expression in tumor samples from a single melanoma patient, researchers from the Johns Hopkins Bloomberg~Kimmel Institute and the Memorial Sloan-Kettering Cancer Center say their findings have the potential to reveal some of the mechanisms underlying response or resistance to immunotherapy drugs.

28 Jun 2017

Engineers take closer look at mechanical and chemical attributes of heart defect

Elastin and collagen serve as the body's building blocks. They provide tensile strength and elasticity for a number of organs, muscles and tissues. Any genetic mutation short-circuiting their function can have a devastating, and often lethal, health impact.

28 Jun 2017

Mouse brain models reveal insights into genetics of autism

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions covering a "spectrum" of symptoms, skills and levels of disability.

28 Jun 2017

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Tiny biological nanoparticles offer enormous potential for diagnostic and therapeutic applications

Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has concluded.

23 Jun 2017

Partnership between CASIS and NCATS brings Organs-on-Chips research to orbiting laboratory

Models of human disease are beneficial for medical research, but have limitations in predicting the way a drug will behave within the human body using data from non-human models because of inherent differences between species.

21 Jun 2017

Type I interferons could have role in natural improvement of RA during pregnancy

An international US-Danish team of scientists, led by Damini Jawaheer, Ph.D. at the UCSF Benioff Children's Hospital Oakland Research Institute, has identified a possible link between type I interferons and a natural improvement of rheumatoid arthritis (RA) during pregnancy.

21 Jun 2017

Cryopreservation of Embryos to Improve Assisted Reproductive Technology

If we were to compare the progression of cryopreservation technology during recent years, we would find that from 2004 to 2013 over a timeframe of a decade, there has been around a 2.5 times increase in the rate of frozen-thawed embryo transfers (FETs) that were reported to the Society for Assisted Reproductive Technology (SART). While the rate of fresh embryo transfers (ET) that were completed was the same.

From Sofia Hospital of Obstetrics, Gynecology and Reproductive Medicine 19 Jun 2017

Study finds direct link between birth outcomes and placental oxygen transport

When a baby is born small, it's often attributed to genetic factors or maternal risk factors like poor nutrition or smoking.

16 Jun 2017

Broccoli may help type 2 diabetes patients manage their blood sugar, study finds

According to a new study, concentrated broccoli sprout extract may help type 2 diabetes patients manage their blood sugar.

16 Jun 2017

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Certain pediatric leukemias share a common underlying cause with treatment-related secondary leukemias.

16 Jun 2017

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) - a newly recognized level of gene expression regulation - in bacterial keratitis – an infection of the cornea caused by bacteria - as well as to identify new therapeutic targets and alternative treatment strategies.

15 Jun 2017

Scientists discover new approach for antifungal drug treatments

Each year, invasive fungal infections sicken an estimated 2 million people worldwide and kill nearly 800,000 - but a team of international scientists have discovered a new approach for antifungal drug treatments.

15 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

SLU scientists discover nuclear receptor that appears to play key role in muscle regeneration

Saint Louis University researchers report in Molecular Metabolism new findings that the nuclear receptor REV-ERB appears to play a key role in muscle regeneration, suggesting the receptor may be a good target for new drugs to treat a variety of muscle disorders and injuries.

14 Jun 2017

Study shows how RNA splicing errors may trigger development of ALS, FTD

The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)- rare and related neurological disorders marked by progressive deterioration of motor or cognitive abilities- may be due to errors in RNA splicing, an intermediary step for translating genetic instructions into functional proteins.

14 Jun 2017

UNC study uncovers crucial function of key enzyme found in virtually all organisms

UNC School of Medicine researchers have cracked a long-standing mystery about an important enzyme found in virtually all organisms other than bacteria.

13 Jun 2017

TSRI scientists solve cellular mystery that may have implications for fundamental biology

Scientists at The Scripps Research Institute have solved a cellular mystery that may have important implications for fundamental biology and diseases like ALS.

13 Jun 2017

Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

The class of immunotherapies known as checkpoint inhibitors have proven to be a highly effective and advantageous treatment option for many cancer patients, but they don't work well for everyone, and oncologists have no reliable way to determine in advance which patients are likely to respond to these drugs.

7 Jun 2017

Studies offer hope for developing new biomarker and drug for neurodegenerative diseases

Two new studies of progressive, neurodegenerative diseases linked to defects in cells' mitochondria offer hope for developing a new biomarker for research and diagnostics, and a drug for treating such diseases, report researchers at the University of California, Davis.

6 Jun 2017

Gene Expression News and Research

Further Reading

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

Engineers take closer look at mechanical and chemical attributes of heart defect

Mouse brain models reveal insights into genetics of autism

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Tiny biological nanoparticles offer enormous potential for diagnostic and therapeutic applications

Partnership between CASIS and NCATS brings Organs-on-Chips research to orbiting laboratory

Type I interferons could have role in natural improvement of RA during pregnancy

Cryopreservation of Embryos to Improve Assisted Reproductive Technology

Study finds direct link between birth outcomes and placental oxygen transport

Broccoli may help type 2 diabetes patients manage their blood sugar, study finds

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Scientists discover new approach for antifungal drug treatments

Researchers bioengineer human liver tissues that mimic natural development

SLU scientists discover nuclear receptor that appears to play key role in muscle regeneration

Study shows how RNA splicing errors may trigger development of ALS, FTD

UNC study uncovers crucial function of key enzyme found in virtually all organisms

TSRI scientists solve cellular mystery that may have implications for fundamental biology

Two-pronged algorithm may prove to be accurate tool for predicting response to checkpoint inhibitors

Studies offer hope for developing new biomarker and drug for neurodegenerative diseases

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