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Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

The Republic of Belarus Ministry of Health has approved expanding the ongoing clinical trial of CureLab Oncology's Elenagen, an experimental DNA therapy, to include two new arms: 1) hormone-resistant breast cancer; and 2) hormone-resistant metastatic prostate cancer.

3 Aug 2021

What is the potential of microphysiological systems in COVID-19 research?

In a recently published review article in the journal Drug Discovery Today, scientists have described the utility of human-based microphysiological systems MPSs in understanding the pathophysiology of SARS-CoV-2 infection and developing effective therapeutic interventions. Moreover, they have described the establishment of a global working group to synchronize recent developments around MPSs and COVID-19 research.

3 Aug 2021

Study examines efficacy Pfizer-BioNTech vaccine among USAF Academy Cadets

A new study published on the medRxiv* preprint server has estimated the effectiveness of vaccines in preventing COVID-19 as a function of time since vaccination.

3 Aug 2021

New model can help clinicians to predict 40-day mortality risk in hospitalized COVID-19 patients

Researchers from Hackensack Meridian University Medical Center and Berry Consultants, LLC, Austin, Texas have developed a new model to help clinicians predict the risk of death within 40 days in patients who are hospitalized with COVID-19 infection.

2 Aug 2021

Pfizer moves towards an oral anti-COVID-19 therapy

Researchers in the United States have described a novel antiviral agent against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being evaluated in clinical trials as a treatment for coronavirus disease 2019 (COVID-19).

2 Aug 2021

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Every year there are nearly ten million new cases of dementia globally, of which Alzheimer's Disease (AD) is the most common form, accounting for around 60-70% of cases.

2 Aug 2021

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

2 Aug 2021

New discovery could pave the way towards therapeutic treatments for many cancers

Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.

2 Aug 2021

Scientists develop a potent peptide inhibitor of SARS-CoV-2 in vitro

In a recently published article in the journal Drugs in R&D, scientists have described the development and validation of a 13-amino acid peptide inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Aug 2021

In-depth sequencing of SARS-CoV-2 variants crucial in controlling outbreaks

In this interview, News-Medical speaks to Professor Dana Crawford about her research efforts during the COVID-19 pandemic.

2 Aug 2021

Fighting SARS-CoV-2 with nanomedicine

Published in the Journal of Controlled Release, researchers from the German University in Cairo, and the University of Cologne, looked into nano-reformulation of repurposed antiviral and immune-modulating drugs for inhalation therapy against COVID-19. In addition, they focused on how nanomedicine could address the limitations of current therapeutics, enhancing the efficacy, specificity, and safety of such drugs.

1 Aug 2021

Finding potential microRNAs from humans and plants against SARS-CoV-2

A new study focuses on the identification of probable miRNA candidates from three medicinal plants.

1 Aug 2021

UT Southwestern discovers the Achilles’ heel in ovarian cancers and potential biomarkers

UT Southwestern faculty have discovered what appears to be an Achilles' heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.

30 Jul 2021

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

A new study published on the bioRxiv preprint server has developed the first computational model, i.e., a signaling network model, that can predict effective repurposed drug combinations to treat different phases of COVID-19 disease. This study has focused on identifying drugs for the treatment of early- and late-stage severe disease.

30 Jul 2021

New insights into participation of underrepresented communities in Alzheimer’s clinical trials

A significant hurdle in developing therapeutics and care models for Alzheimer's disease that work for people of all ethnic and racial backgrounds is the recruitment and retention of traditionally underrepresented groups in clinical trials.

29 Jul 2021

Drug combination could make curative surgery possible for some liver cancer patients

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.

29 Jul 2021

Removing RNA-binding protein in subtype of leukemia can help to slow the cancer's development

Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer's development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.

28 Jul 2021

Mini-antibodies efficiently block SARS-CoV-2 virus

Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.

28 Jul 2021

Women say California insurer makes it too hard to get drug for postpartum depression

When Miriam McDonald decided she wanted to have another baby at age 44, her doctor told her she had a better chance of winning the lottery. So when she got pregnant right away, she and her husband were thrilled. But within three days of giving birth to their son, in September 2019, everything shifted.

28 Jul 2021

SARS-CoV-2 variants of concern employ different strategies of antibody escape

A recent study in the field of fluid analysis reveals a diverse set of strategies utilized by alpha and beta variants of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) in order to evade antibodies generated during an earlier infection with this virus. The paper is currently available on the bioRxiv* preprint server while it undergoes a peer-review process.

28 Jul 2021

Therapeutics News and Research

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

What is the potential of microphysiological systems in COVID-19 research?

Study examines efficacy Pfizer-BioNTech vaccine among USAF Academy Cadets

New model can help clinicians to predict 40-day mortality risk in hospitalized COVID-19 patients

Pfizer moves towards an oral anti-COVID-19 therapy

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

New discovery could pave the way towards therapeutic treatments for many cancers

Scientists develop a potent peptide inhibitor of SARS-CoV-2 in vitro

In-depth sequencing of SARS-CoV-2 variants crucial in controlling outbreaks

Fighting SARS-CoV-2 with nanomedicine

Finding potential microRNAs from humans and plants against SARS-CoV-2

UT Southwestern discovers the Achilles’ heel in ovarian cancers and potential biomarkers

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

New insights into participation of underrepresented communities in Alzheimer’s clinical trials

Drug combination could make curative surgery possible for some liver cancer patients

Removing RNA-binding protein in subtype of leukemia can help to slow the cancer's development

Mini-antibodies efficiently block SARS-CoV-2 virus

Women say California insurer makes it too hard to get drug for postpartum depression

SARS-CoV-2 variants of concern employ different strategies of antibody escape

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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