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Natural compound forskolin enhances chemotherapy effectiveness against aggressive leukemia

A natural compound could help fight aggressive leukaemia and amplify the effect of chemotherapy drugs.

26 Aug 2025

New research reveals why blood clotting malfunctions in inflammatory bowel disease

Inflammatory bowel disease, in which the immune system attacks the gut, is a painful chronic condition that affects three million Americans. Rates of IBD are rising, and there's currently no cure. IBD can also be deadly: up to 8% of people with the disease develop blood clots, which can lead to heart attack and stroke.

25 Aug 2025

Indole chemistry breakthrough opens doors for more effective drug synthesis

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds.

25 Aug 2025

Balancing speed and selectivity is key for designing effective targeted covalent inhibitors

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs).

22 Aug 2025

Working-age adults with disabilities face much higher rates of loneliness

Working-age adults with disabilities experience far higher rates of loneliness than those without, according to a new study from researchers at the Brown University School of Public Health and the Warren Alpert Medical School.

22 Aug 2025

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality.

22 Aug 2025

Natural products offer promising solutions in prosthodontics and oral implantology

Infection control is paramount in prosthodontics and oral implantology to prevent complications like denture stomatitis and peri-implantitis.

22 Aug 2025

Hemoglobin emerges as a natural antioxidant defense in the brain

Did you know the same protein that gives blood its red color and carries oxygen throughout the body is also present inside brain cells? Hemoglobin, long celebrated for ferrying oxygen in red blood cells, has now been revealed to play an overlooked - and potentially game-changing - antioxidant role in the brain.

22 Aug 2025

AI predicts designer drug structures for improved detection

How does one identify something no one has a test for? Designer drugs replicate the effects of known, illicit drugs but evade law enforcement. The chemical structure variations that help these compounds avoid detection also make them unpredictable in the body - a quality that poses serious health consequences.

21 Aug 2025

Dengue antibody may block the spread of Zika virus in vulnerable areas of the body

A new study from the University of Alabama at Birmingham reveals that an antibody originally designed to fight dengue virus may also block the spread of Zika virus in vulnerable areas of the body - including the reproductive organs.

19 Aug 2025

Reducing FTL1 protein levels reverses brain aging and improves memory in mice

Aging is particularly harsh on the hippocampus - the brain region responsible for learning and memory.

19 Aug 2025

Researchers investigate how citrus bioflavonoid naringin could reduce inflammation and heart risk

Researchers reviewed 62 studies on naringin, a citrus flavonoid, and found strong preclinical evidence for its cardioprotective effects, including improved endothelial function, reduced oxidative stress, and protection against myocardial injury.

18 Aug 2025

New molecule shows promise in treating acetaminophen-induced liver injury

Acetaminophen is one of the most common painkillers and is found in hundreds of different medications. While safe at recommended doses, acetaminophen overdose is the leading cause of acute liver injury in the U.S.

18 Aug 2025

Study shows promising anti-diabetic potential of coffee's functional components

Three of the compounds demonstrated significant inhibitory effects on α-glucosidase, a key enzyme in carbohydrate digestion. The findings could pave the way for new functional food ingredients targeting type 2 diabetes.

18 Aug 2025

Using AI to enhance the design of nanoparticles for RNA therapies

Using artificial intelligence, MIT researchers have come up with a new way to design nanoparticles that can more efficiently deliver RNA vaccines and other types of RNA therapies.

18 Aug 2025

Heated herbal product delivers nicotine with fewer toxins

Research on the iSENZIA™ system shows it provides nicotine with significantly lower harmful chemicals, highlighting its tobacco harm reduction potential.

18 Aug 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025

New compound shows promise against aromatase inhibitor-resistant breast cancer

A new research paper was published in Volume 16 of Oncotarget on July 29, 2025, titled "PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion."

13 Aug 2025

Light-activated therapy boosts effectiveness of antifungal drugs against Candida albicans

Researchers at the Optics and Photonics Research Center (CePOF) have succeeded in increasing the susceptibility of the fungus Candida albicans to drug treatment through light-activated therapy.

12 Aug 2025

Compound News and Research

Natural compound forskolin enhances chemotherapy effectiveness against aggressive leukemia

New research reveals why blood clotting malfunctions in inflammatory bowel disease

Indole chemistry breakthrough opens doors for more effective drug synthesis

Balancing speed and selectivity is key for designing effective targeted covalent inhibitors

Working-age adults with disabilities face much higher rates of loneliness

ATOX1 drives hepatocellular carcinoma progression through c-Myb and PI3K/AKT activation

Natural products offer promising solutions in prosthodontics and oral implantology

Hemoglobin emerges as a natural antioxidant defense in the brain

AI predicts designer drug structures for improved detection

Dengue antibody may block the spread of Zika virus in vulnerable areas of the body

Reducing FTL1 protein levels reverses brain aging and improves memory in mice

Researchers investigate how citrus bioflavonoid naringin could reduce inflammation and heart risk

New molecule shows promise in treating acetaminophen-induced liver injury

Study shows promising anti-diabetic potential of coffee's functional components

Using AI to enhance the design of nanoparticles for RNA therapies

Heated herbal product delivers nicotine with fewer toxins

Electrophysiology-based strategies enhance cancer immunotherapy

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

New compound shows promise against aromatase inhibitor-resistant breast cancer

Light-activated therapy boosts effectiveness of antifungal drugs against Candida albicans

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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