Clinical Trial News and Research

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Novel rapid genetic test could spare 14,000 newborns from lifelong hearing loss

Clinicians and nurses in neonatal intensive care units (NICU) across Manchester University NHS Foundation Trust (MFT) are the world’s first to deploy genedrive’s MT-RNR1 ID Kit, a new rapid genetic point of care test (POCT) to screen babies for the genetic variant m.1555A>G when admitted with suspected sepsis

4 Apr 2022

Patiromer lowers hyperkalemia risk in heart failure patients taking RAASi therapy

Patients taking renin-angiotensin-aldosterone system inhibitor (RAASi) medications for heart failure had significantly lower blood potassium levels when taking patiromer—a drug that helps to prevent the body from absorbing too much potassium—compared with a placebo, in a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

New drug shows promise in relieving symptoms associated with hypertrophic cardiomyopathy

A new drug shows promise in providing relief to cardiomyopathy patients experiencing shortness of breath, according to late-breaking research presented today at the American College of Cardiology (ACC) Scientific Session in Washington, D.C.

3 Apr 2022

New evidence on how salt reduction can benefit heart failure patients

For the past century people with weak hearts have been told to lower their salt intake, but until now there has been little scientific evidence behind the recommendation.

2 Apr 2022

Virtual population used to replicate a clinical trial that examines kidney damage in Black Americans

Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson. John S. Clemmer, PhD, a physiologist and lead author of the study, said his team model used a calcium channel blocker to predict kidney damage.

2 Apr 2022

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.

2 Apr 2022

Limiting sodium intake results in improved quality of life for patients with heart failure

Nutrition counseling and strictly limiting salt intake for one year in patients with heart failure resulted in improved quality of life and a slowing in the progression of the disease, but a study presented at the American College of Cardiology's (ACC) 71st Annual Scientific Session found reducing salt intake did not significantly reduce major adverse events or hospitalizations.

2 Apr 2022

Convalescent plasma treatment for newly diagnosed COVID-19 patients may reduce hospitalization risk

Early treatment of newly diagnosed COVID-19 patients with plasma extracted from individuals who have recovered from the disease reduces the need for hospitalization by more than 50%, according to a new nationwide clinical trial.

31 Mar 2022

Waiver will continue to be applied for COVID-19 antiviral medicines and therapeutic treatments

We are pleased to announce that the arrangements that were made for the purposes of regulation 13 of the National Health Service (Charges for Drugs and Appliances) Regulations 2015, for antiviral medicines to be supplied for free to patients who have tested positive for COVID-19 and who are eligible to receive antiviral treatments for COVID-19 via Covid Medicines Delivery Units (CMDUs), will be extended until 31st March 2023.

31 Mar 2022

NIH-sponsored trial of second COVID-19 booster shots begins enrolling adult participants

A Phase 2 clinical trial evaluating various additional COVID-19 booster shots has begun enrolling adult participants in the United States.

31 Mar 2022

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Are we moving closer to the day when diabetes is no longer monitored and managed with blood sugar tests, insulin injections and drug treatments? A GE Research-led team, which includes The Feinstein Institutes for Medical Research, UCLA Samueli School of Engineering, Yale School of Medicine, and Albany Medical College, has demonstrated the ability to prevent or reverse the onset of diabetes in studies of three different preclinical model systems.

31 Mar 2022

Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

Very premature babies need extra oxygen and mechanical intervention to breathe, but this damages their lungs, causing a chronic lung disease called bronchopulmonary dysplasia (BPD).

30 Mar 2022

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

Scientists urge African leaders to demand fair licensing following clinical trials of an HIV vaccine candidate.

30 Mar 2022

A ferritin nanoparticle candidate vaccine for COVID

In a recent study published on the bioRxiv* preprint server, the immunogenicity, and effectiveness of SARS-CoV-2 spike ferritin nanoparticle (SpFN) adjuvanted with aluminum hydroxide (AlOH3) or Army Liposomal Formulation QS-21 (ALFQ) in a cynomolgus macaque (CM) COVID-19 model was evaluated.

30 Mar 2022

Researchers present a possible therapeutic approach for severe congenital myopathy

The diagnosis is rare, but devastating – children with congenital muscle disorders often never learn to walk. Until now, there was no chance of recovery, but researchers at the University of Basel and University Hospital Basel are now presenting a possible therapeutic approach for the first time.

29 Mar 2022

Study shows clinical value of pharmacogenomic testing for patients with treatment-resistant depression

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a Centre for Addiction and Mental Health- (CAMH-)led clinical study just published in the journal Translational Psychiatry.

29 Mar 2022

Risk for anaphylaxis higher with two intravenous iron formulations

Two products commonly administered intravenously to replenish iron levels in the body have a much higher chance of provoking a severe allergic attack, according to Rutgers researchers who conducted a study analyzing the medical records in a large database of older, Medicare patients.

29 Mar 2022

Trial shows effectiveness of new classes of dual active ingredient insecticidal nets against malaria

IVCC welcomes the publication in The Lancet of the 24-month results of an epidemiological trial in Tanzania, conducted by the London School of Hygiene and Tropical Medicine in partnership with the National Institute for Medical Research, Kilimanjaro Christian Medical University College, and the University of Ottawa, to assess the public health value of two dual active ingredient nets compared to standard LLINs containing pyrethroids only.

29 Mar 2022

New technology could replace conventional biopsies and histology with real-time imaging

MediSCAPE, a high-speed 3D microscope designed by Columbia Engineers, can see real-time cellular detail in living tissues to guide surgery, speed up tissue analyses, and improve treatments.

28 Mar 2022

How malaria drugs could play a part in treating chemotherapy-resistant head and neck cancers

In this interview, we speak to Kirill Kiselyov, Ph.D, and Umamaheswar Duvvuri, M.D, Ph.D, from the University of Pittsburgh, about their latest research into hydroxychloroquine, a drug widely used to prevent and treat malaria, as a potential treatment for head and neck cancers.

28 Mar 2022

Clinical Trial News and Research

Novel rapid genetic test could spare 14,000 newborns from lifelong hearing loss

Patiromer lowers hyperkalemia risk in heart failure patients taking RAASi therapy

New drug shows promise in relieving symptoms associated with hypertrophic cardiomyopathy

New evidence on how salt reduction can benefit heart failure patients

Virtual population used to replicate a clinical trial that examines kidney damage in Black Americans

Experimental drug for hypertrophic cardiomyopathy reduces the need for invasive procedures, trial shows

Limiting sodium intake results in improved quality of life for patients with heart failure

Convalescent plasma treatment for newly diagnosed COVID-19 patients may reduce hospitalization risk

Waiver will continue to be applied for COVID-19 antiviral medicines and therapeutic treatments

NIH-sponsored trial of second COVID-19 booster shots begins enrolling adult participants

GE-led team uses ultrasound to prevent or reverse Type-2 diabetes in preclinical models

Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

Clinical trials for experimental HIV vaccines based on mRNA technology begin in United States

A ferritin nanoparticle candidate vaccine for COVID

Researchers present a possible therapeutic approach for severe congenital myopathy

Study shows clinical value of pharmacogenomic testing for patients with treatment-resistant depression

Risk for anaphylaxis higher with two intravenous iron formulations

Trial shows effectiveness of new classes of dual active ingredient insecticidal nets against malaria

New technology could replace conventional biopsies and histology with real-time imaging

How malaria drugs could play a part in treating chemotherapy-resistant head and neck cancers

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