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Finding potential biomarkers to predict response to immunotherapy in nonhypermutated cancers

Scientists have discovered a potential biomarker that could more accurately identify which patients with non-hypermutated cancers will respond to specialized immunotherapy drugs called immune checkpoint inhibitors, according to findings published in Science Translational Medicine.

24 Nov 2021

Bat coronavirus ecology, evolution, and spillover

In a review published in Nature Reviews Microbiology, the authors collate information about the ecology and evolution of bat coronaviruses.

24 Nov 2021

Spread and evolution of SARS-CoV-2 lineages with possible recombination events

Researchers examined the dissemination and evolution of four SARS-CoV-2 lineages as well as the potential that one or more recombination events played a role in their evolution.

24 Nov 2021

Vaping linked to dysregulation of mitochondrial genes and immune response genes

Since they hit the market, e-cigarettes have been touted as a safe alternative to tobacco cigarettes for adult smokers.

24 Nov 2021

An increase in the half-life of remdesivir for COVID-19 treatment

In this study, researchers analyzed several drug candidates to investigate their efficacy against a broad spectrum of coronaviruses in cell culture studies.

23 Nov 2021

Interferon beta versus the SARS-CoV-2 Delta variant

In a study recently published on the bioRxiv* preprint server, researchers investigated the difference in replication efficiency or IFN sensitivity of the four VOCs.

22 Nov 2021

Clearing old, dysfunctional cells in fat alleviates diabetes

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes, researchers from UConn Health report. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

22 Nov 2021

Washington University joins international effort to support data science research and training in Africa

Washington University in St. Louis is joining a major international effort to advance data science, catalyze innovation and spur health discoveries across Africa.

21 Nov 2021

Human Proteoform Project aims to define the entire collection of proteins in the body

Now that the Human Genome Project has officially wrapped, an international team of researchers will map the entire collection of proteins in the human body.

21 Nov 2021

Novel technique solves structure of the HIV capsid alone and in complex with host factors

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

21 Nov 2021

Researchers use embryonic stem cell model to study genetic architecture in the hypothalamus

A study led by researchers at Children's Hospital of Philadelphia has implicated several genes involved in a variety of bodily functions associated with the hypothalamus, a notoriously difficult-to-study region of the brain.

21 Nov 2021

Sharing large-scale health data to drive forward precision medicine

Precision medicine requires big data. In order to improve the treatment of individuals with cancer, or to understand rare diseases, scientists and clinicians, as well as AI technologies require access to larger sets of health research data that covers diverse populations and wide ranges of conditions.

20 Nov 2021

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

20 Nov 2021

Effectiveness of COVID-19 vaccination during Delta variant predominance

A new study investigated the continued effectiveness of COVID-19 vaccination during the delta variant predominance in a diverse and urban healthcare setting.

19 Nov 2021

Functions of glycosylation in SARS-CoV-2 proteins and human receptor ACE2

In a review published in Signal Transduction and Targeted Therapy, researchers from Sichuan University have reviewed the available literature.

19 Nov 2021

Viral biomolecular condensation

A review published in PLOS Pathogens deconstructs virus condensation and provides a biochemical background for LLPS.

19 Nov 2021

New study highlights the important role of rare genomic differences in OCD risk

Both rare and commonly observed differences in the DNA letters strung along a person's chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study led by scientists at the Icahn School of Medicine at Mount Sinai.

18 Nov 2021