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AI and whole genome sequencing improve quick detection of infectious disease outbreaks

By coupling machine learning with whole genome sequencing, University of Pittsburgh School of Medicine and Carnegie Mellon University scientists greatly improved the quick detection of infectious disease outbreaks within a hospital setting over traditional methods for tracking outbreaks.

17 Nov 2021

Study may help predict genomic changes that may happen in advanced cancers based on therapy

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Now, researchers from Public Health Services Israel have been investigating a new variant called Lambda to see if it qualifies as a variant of concern. Their research is published in the journal Eurosurveillance.

16 Nov 2021

Young adults with cancer may require different treatments than older patients

Not all tumors are alike. Young adults who are diagnosed with skin, colon, and other cancer types may require different treatments than older patients receive.

16 Nov 2021

Novel long-read sequencing reveals complete repertoire of brain-expressed gene isoforms

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including the identification of novel isoforms of genes involved in diseases including Alzheimer's disease, autism and schizophrenia.

16 Nov 2021

Scientists identify new gene that contributes to type 1 diabetes progression

When the pro-inflammatory pair, a receptor called CCR2 and its ligand CCL-2, get together, it increases the risk of developing type 1 diabetes, scientists report.

16 Nov 2021

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Scientists have hypothesized that the presence of regulatory sequences could be effectively used to instantaneously and accurately identify TRS sites as well as the related viral genes in unannotated coronavirus genomes.

16 Nov 2021

Researchers develop a highly efficient method to generate immune cells for cancer therapies

A Ludwig Cancer Research study has devised a highly efficient method to generate large numbers of immune cells specifically engineered to recognize neoantigens - small fragments of randomly mutated proteins that are typically unique to a patient's cancer - and destroy the tumors that express them.

15 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs (lncRNAs) – which are understudied in cancer research.

15 Nov 2021

Lamin C important for keeping cell’s genetic material organized, research shows

In a study with lab-grown mouse cells, Johns Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell's "command center" — its nucleus — is key to ensuring that DNA inside it remains orderly.

15 Nov 2021

Updated mapping of the human genetic architecture of COVID-19

In the present study, researchers presented extensive meta-analysis and added ten new genome-wide significant loci.

15 Nov 2021

Public health strategies associated with reduced SARS-CoV-2 transmission in Switzerland

The current study attempts to estimate the quantitative effects of specific measures, using a combination of phylogenetic and phylodynamic approaches.

15 Nov 2021

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Now, a new study published in the journal Nature Communications reports the identification of SARS-CoV-2 related coronaviruses in two horseshoe bats sampled in Cambodia in 2010.

15 Nov 2021

Study provides a new target for therapeutic intervention in Parkinson's disease

In an unexpected discovery, Georgetown University Medical Center researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson's disease.

14 Nov 2021

Scientists develop a single-cell chromatin atlas for the human genome

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome.

14 Nov 2021

Xanthohumol as a potent pan-inhibitor for various coronaviruses

Researchers from China reported the results of their study aimed at finding an effective Mpro inhibitor since Mpro is the best drug target to fight SARS-CoV-2 infection.

12 Nov 2021

Rare disease diagnosis by 100,000 genomes pilot

A team of researchers conducted a pilot study that enrolled families and undertook detailed clinical phenotyping of the proband to evaluate the effect of the whole genome sequencing approach on a genetic diagnosis of rare conditions by the NHS in the UK.

12 Nov 2021

Genome News and Research

AI and whole genome sequencing improve quick detection of infectious disease outbreaks

Study may help predict genomic changes that may happen in advanced cancers based on therapy

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

How effective is the COMIRNATY BNT162b2 vaccine against the SARS-CoV-2 Lambda variant?

Young adults with cancer may require different treatments than older patients

Novel long-read sequencing reveals complete repertoire of brain-expressed gene isoforms

Scientists identify new gene that contributes to type 1 diabetes progression

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Researchers develop a highly efficient method to generate immune cells for cancer therapies

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

Lamin C important for keeping cell’s genetic material organized, research shows

Updated mapping of the human genetic architecture of COVID-19

Public health strategies associated with reduced SARS-CoV-2 transmission in Switzerland

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Study provides a new target for therapeutic intervention in Parkinson's disease

Scientists develop a single-cell chromatin atlas for the human genome

Xanthohumol as a potent pan-inhibitor for various coronaviruses

Rare disease diagnosis by 100,000 genomes pilot

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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