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Cas12a-based bio-sensor for detecting SARS-CoV-2 mutations

Scientists develop an improved biosensor with Cas12a-based CRISPR on-site rapid detection system and discuss its ability to detect SARS-CoV-2 VOCs.

7 Dec 2021

Possible impact of spike protein mutations on SARS-CoV-2 Omicron variant

The current study not only analyses the mutations in the Omicron spike variant but classifies various combinations of spike mutations into groups.

7 Dec 2021

Impact of post-translational modifications in the pathogenicity of SARS-CoV-2

A new study provides understanding of the intricate roles and functions of the different elements of spike proteins and shows how the spike protein samples a crowded surface of its host cell via the glycans.

7 Dec 2021

Community transmission of SARS-CoV-2 lineage with novel mutations in Florida

A new study describes the introduction and spread of a SARS-CoV-2 lineage, A.2.5 in Florida using samples from the Florida Department of Health (FDOH) Bureau of Public Health Laboratories (BPHL).

7 Dec 2021

Genome sequencing efforts overlook huge swathes of diversity and opportunity, researchers warn

Efforts to sequence the genomes of the world's animals tend to focus on those that most resemble humans with the work conducted almost entirely in the Global North, according to an analysis led by Washington State University.

7 Dec 2021

SARS-CoV-2 Delta saliva viral load 15 times that of the wild type

Researchers hypothesize that a higher viral load of SARS-CoV-2 Delta variant in saliva contributes to its high transmissibility.

6 Dec 2021

Researchers use gene-editing to create single sex mice litters

Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency.

6 Dec 2021

The link between cytokine storms and cardiovascular problems in COVID-19 patients

New findings may help doctors choose effective COVID-19 treatment regimens for patients with heart complications.

6 Dec 2021

New therapeutic targets for the treatment and prevention of hypertension, cardiovascular diseases

Cardiovascular diseases are the leading cause of death worldwide. Although the development of these disorders is most commonly associated with lifestyle factors like obesity, increasing evidence suggests that events much earlier in one's life can also play a role.

6 Dec 2021

SARS-CoV-2 ORF10 degrades mitochondrial antiviral signaling protein to suppress immune response

A novel mechanism by which SARS-CoV-2 inhibits the innate immune response; that is, ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX.

5 Dec 2021

The emergence and evolution of SARS-CoV-2 and its VOCs

A review article discusses the evolution of SARS-CoV-2 and the emergence of variants of concern.

5 Dec 2021

Characterization of two novel SARS-CoV-2 delta variant sublineages

Researchers characterized the two novel AY.43 sublineages of the SARS-CoV-2 delta variant with probable Brazilian origin.

3 Dec 2021

CRISPR-based DETECTR® assay for faster SARS-CoV-2 surveillance

Researchers from the USA discuss the development and validation of CRISPR-Cas12-based COVID-19 variant DETECTR® assay for the detection of SARS-CoV-2.

3 Dec 2021

Modeling emergence and dynamics of new COVID-19 variants in the UK

Computer simulations describe global features observed in the daily number of cases and can be applied to any country of interest.

3 Dec 2021

Study documents and visualizes hearing loss-associated genes in the inner ear

Researchers from Uppsala University have been able to document and visualise hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists.

2 Dec 2021

SARS-CoV-2 evolution in animals could provide insights on the mutability of COVID-19

When animals catch COVID-19 from humans, new SARS-CoV-2 variants can arise. To evaluate this phenomenon, an interdisciplinary team at the College of Veterinary Medicine and Biomedical Sciences systematically analyzed mutation types occurring in the virus after infection of cats, dogs, ferrets, and hamsters.

2 Dec 2021

Men with inherited gene mutation have high risk of aggressive prostate cancer

Men who inherit mutations in a gene called TP53 have a high risk of developing aggressive prostate cancer, a multicenter research team in the United States has found.

2 Dec 2021

Researchers introduce new method for observing cell interactions

Researchers created a system that allows scientists to ‘log’ a cell’s reactions to external stimuli within the cell’s genetic material.

2 Dec 2021

New bioinformatics method for viral sgRNA analysis

A recent study discusses a bioinformatics method to help identify and explore sgRNAs uncovered in next-generation sequencing data.

2 Dec 2021

Large study of plasma proteome unravels its genetic determinants and relationship with human disease

In a study published today in Nature Genetics, scientists at deCODE genetics , a subsidiary of the pharmaceutical company Amgen, demonstrate how measuring the levels of a large number of proteins in plasma at population scale when combined with data on sequence diversity and RNA expression dramatically increases insights into human diseases and other phenotypes.

2 Dec 2021