Preclinical News and Research

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CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

Preclinical results of research by City College of New York scientists and TechnoVax, Inc. in animal models demonstrate favorable outcomes in developing a vaccine against the mosquito-borne Zika virus.

11 May 2017

Serum Institute signs licensing agreement to commercialize St. Jude vaccine against RSV

St. Jude Children's Research Hospital and the Serum Institute of India have signed a licensing agreement to complete development and commercialization of a St. Jude vaccine against the respiratory syncytial virus (RSV), the virus that causes croup and lower respiratory infections. RSV kills about 160,000 people, primarily infants, worldwide each year.

10 May 2017

BGRF scientists help develop AI to expedite drug development for age-related conditions

The Chief Science Officer of the Biogerontology Research Foundation will present new research on artificial intelligence for drug discovery at the NVIDIA Graphics Technology Conference at the San Jose Convention Center, on Wednesday, May 10, 1:00 PM - 1:50 PM alongside two AI scientists from the BGRF and Insilico Medicine, where they will deliver a presentation titled "Applications of Generative Adversarial Networks to Drug Discovery in Oncology and Infectious Diseases".

9 May 2017

Experts find benefits of antipsychotic medications to be much greater than side effects

An international group of experts has concluded that, for patients with schizophrenia and related psychotic disorders, antipsychotic medications do not have negative long-term effects on patients' outcomes or the brain.

5 May 2017

New conference aims to improve understanding of how advances in genomics influence society

From prenatal genetic screening to the genetic testing of women with family histories of breast cancer, genomics is rapidly becoming a fixture in our lives.

5 May 2017

UAB spinoff develops drug-resistant immunotherapy to combat solid tumors

The University of Alabama at Birmingham and two partner institutions have received a European patent for their novel approach to fighting cancer, an approach that is led by the UAB spinoff biopharmaceutical company Incysus Ltd.

5 May 2017

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

Columbia University Medical Center researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy.

4 May 2017

Detailed images reveal how regulatory proteins affect function of brain receptors

Scientists at Columbia University have obtained the first detailed images of interactions between the AMPA receptor and molecules that regulate chemical signaling in the brain.

3 May 2017

Scientists map genetic changes that help drive aggressive brain tumor

University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators have mapped genetic changes that help drive an aggressive tumor as it develops in the brain – helping to lay the foundation for targeted treatment of the disease.

3 May 2017

Study finds no link between gluten intake and heart disease risk in people without celiac disease

A study of more than 100,000 men and women revealed that dietary gluten is not associated with heart disease risk in people without celiac disease. The findings also suggest that limiting whole grains as part of a low-gluten diet may increase the risk of heart disease in people who do not have celiac disease.

3 May 2017

Researchers create new tool that reveals insights into cellular development

Researchers at Columbia University Medical Center have created a new tool to describe the many possible ways in which a cell may develop. Rooted in the mathematical field of topology, the tool provides a roadmap that offers detailed insight into how stem cells give rise to specialized cells.

2 May 2017

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

Combination therapy may be effective option for treating some women with ovarian cancer

Researchers have been trying to understand why up to 85 percent of women experience recurrence of high-grade serous ovarian cancer -- the most common subtype of ovarian cancer -- after standard treatment with the chemotherapy drug carboplatin.

2 May 2017

Novel strategy may improve survival of grafts, outcomes in high-risk corneal transplant patients

Treating donor corneas with a cocktail of molecules prior to transplanting to a host may improve survival of grafts and, thus, outcomes in high-risk corneal transplant patients, according to a new study led by researchers at Massachusetts Eye and Ear.

2 May 2017

New study makes wireless medical electronics for treating the GI tract one step closer to reality

Imagers, gastric pacemakers and other diagnostic and therapeutic tools could someday transform the way diseases of the gastrointestinal tract are measured and treated. But in order for these electronic devices to work, they need a power source.

27 Apr 2017

Improvements to animal testing protocols could yield more useful clinical results

The use of animals in biomedical research has long been the focus of campaigns by animal rights activists. Two leading scientists writing in the European Journal of Internal Medicine give their expert view of the importance of animal testing to medical progress and present ways it could be further improved to yield more useful clinical results.

27 Apr 2017

Preclinical News and Research

CUMC researchers create new organoids that mimic features of full-sized lung

Preclinical results of translational research show favorable outcomes in developing Zika virus vaccine

Serum Institute signs licensing agreement to commercialize St. Jude vaccine against RSV

BGRF scientists help develop AI to expedite drug development for age-related conditions

Experts find benefits of antipsychotic medications to be much greater than side effects

New conference aims to improve understanding of how advances in genomics influence society

UAB spinoff develops drug-resistant immunotherapy to combat solid tumors

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

Detailed images reveal how regulatory proteins affect function of brain receptors

Scientists map genetic changes that help drive aggressive brain tumor

Study finds no link between gluten intake and heart disease risk in people without celiac disease

Researchers create new tool that reveals insights into cellular development

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Combination therapy may be effective option for treating some women with ovarian cancer

Novel strategy may improve survival of grafts, outcomes in high-risk corneal transplant patients

New study makes wireless medical electronics for treating the GI tract one step closer to reality

Improvements to animal testing protocols could yield more useful clinical results

Removing senescent cells from joints could reverse progression of osteoarthritis

MedCision and TrakCel to present clinical cell thawing technologies at ISCT

Study highlights need for personalized approaches to prostate cancer screening in high-risk black men

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