Preclinical News and Research

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Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa.

21 Apr 2017

Sugary drinks may impact memory and diet alternatives could cause dementia

New research, published in both Alzheimer's & Dementia and Stroke indicate that drinking sugary drinks regularly may lead to a reduction in the size of the brain and poorer memory.

21 Apr 2017

MR Solutions introduces sealed animal handling beds for use in cleanroom environments

MR Solutions’ preclinical, cryogen-free multi-modality, MRI systems can now be sited in cleanroom environments with the addition of a sealed animal handling bed.

From MR Solutions 19 Apr 2017

Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases

Researchers in France have developed a new method that will allow doctors to detect minute amounts of a protein called interferon-a in patient samples.

18 Apr 2017

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Through experimental work, an international team of researchers led by City of Hope's Defu Zeng, professor of diabetes immunology and hematopoietic cell transplantation, believe they may have found a way to prevent graft-versus-host disease after stem cell transplants while retaining the transplants' positive effects on fighting leukemia and lymphoma.

18 Apr 2017

Nanoparticle-programmed immune cells can slow progression of leukemia in mouse model

Researchers at Fred Hutchinson Cancer Research Center have developed biodegradable nanoparticles that can be used to genetically program immune cells to recognize and destroy cancer cells -- while the immune cells are still inside the body.

17 Apr 2017

Th17 cell durability offers promise for next-generation adoptive cancer immunotherapy trials

Medical University of South Carolina investigators report that long-term expansion protocols for adoptive cancer immunotherapy do not compromise Th17 cells' effectiveness against large tumors, in the March 9, 2017 issue of JCI Insight.

17 Apr 2017

Study shows um-PEA as safe and efficacious adjuvant treatment for advanced PD patients

Parkinson disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

12 Apr 2017

Scientists discover novel therapeutic target for retinal neovascularization

A team led by Massachusetts Eye and Ear researchers has identified a novel therapeutic target for retinal neovascularization, or abnormal blood vessel growth in the retina, a hallmark of advanced diabetic eye disease (proliferative diabetic retinopathy).

11 Apr 2017

Antimicrobial protein reduces creamy white lesions linked to oral thrush in mouse models

An antimicrobial protein caused a dramatic reduction in the creamy white lesions associated with oral thrush in a preclinical study, report microbiologists with McGovern Medical School at The University of Texas Health Science Center at Houston.

11 Apr 2017

Tiny light-emitting particles may provide unprecedented detail in biological imaging

For certain frequencies of short-wave infrared light, most biological tissues are nearly as transparent as glass. Now, researchers have made tiny particles that can be injected into the body, where they emit those penetrating frequencies.

10 Apr 2017

New model can simplify process of identifying optimal blends for drug cocktails

Drug cocktails such as those for treating cancer, like the alcoholic versions offered at the local bar, are best when the proper ingredients are mixed in the right proportions.

10 Apr 2017

Study offers new hope for early attack against Alzheimer's

Catch it early. Those are watchwords in the battle against a host of illnesses, from heart disease to cancer to Type 2 diabetes.

7 Apr 2017

Cognitive decline following surgery triggered by brain's own immune cells, study suggests

After undergoing surgery, elderly patients often experience cloudy thinking that can last for weeks or even months. At one time researchers thought this cognitive decline might be caused by anesthesia, but mounting evidence suggests that heightened inflammation in the brain following surgery is the more likely cause.

6 Apr 2017

Experimental treatment cures Marburg and Ravn virus infection in animals

Scientists funded by the National Institutes of Health have found that an experimental treatment cured 100 percent of guinea pigs and rhesus monkeys in late stages of infection with lethal levels of Marburg and Ravn viruses, relatives of the Ebola virus.

5 Apr 2017

Preclinical News and Research

Researchers use gene-editing tool to restore visual function in mouse models of retinitis pigmentosa

Sugary drinks may impact memory and diet alternatives could cause dementia

MR Solutions introduces sealed animal handling beds for use in cleanroom environments

Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Nanoparticle-programmed immune cells can slow progression of leukemia in mouse model

Th17 cell durability offers promise for next-generation adoptive cancer immunotherapy trials

Study shows um-PEA as safe and efficacious adjuvant treatment for advanced PD patients

Scientists discover novel therapeutic target for retinal neovascularization

Antimicrobial protein reduces creamy white lesions linked to oral thrush in mouse models

Tiny light-emitting particles may provide unprecedented detail in biological imaging

New model can simplify process of identifying optimal blends for drug cocktails

Study offers new hope for early attack against Alzheimer's

Cognitive decline following surgery triggered by brain's own immune cells, study suggests

Experimental treatment cures Marburg and Ravn virus infection in animals

New initiative aims to study relationship between brain and obesity

Researchers achieve new step towards treatment of myotubular myopathy using gene therapy

Tumor microenvironment poses unique challenges for effective ovarian cancer T-cell therapy

Researchers discover potential novel strategy for improving immunotherapy against cancer

Amgen, UCB present romosozumab Phase 2 results at ENDO 2017

Event guide: 4th LNP Formulation & Process Development Summit eBook

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