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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Researchers identify never-before-defined subtypes of a blood cancer

Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma.

17 Nov 2021

Study may help predict genomic changes that may happen in advanced cancers based on therapy

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

Researchers from the Humboldt-Universität zu Berlin have been investigating the presence of these antibodies in hospitalized COVID-19 patients to examine the potential of using them as a biomarker for severe disease.

17 Nov 2021

Game animals as potential drivers of disease emergence

A study characterized the total virome of game animals from five mammalian orders using the total RNA sequencing technique.

17 Nov 2021

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

A new study published in the journal Diagnostics was based on the hypothesis that detecting urinary SARS-CoV-2 nucleic acid––which may result in renal and cardiovascular endothelial destruction to facilitate viral access to the kidney parenchyma—may be used as a specific biomarker to indicate the severity of COVID-19.

16 Nov 2021

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

Study: Covid-19 vaccine-elicited immune cells persist six months after vaccination

A recent study by Johns Hopkins Medicine researchers provides evidence that CD4+ T lymphocytes — immune system cells also known as helper T cells — produced by people who received either of the two available messenger RNA (mRNA) vaccines for COVID-19 persist six months after vaccination at only slightly reduced levels from two weeks after vaccination and are at significantly higher levels than for those who are unvaccinated.

16 Nov 2021

A therapeutic interfering particle for SARS-CoV-2

Researchers report their attempt to engineer TIPs that can conditionally replicate with SARS-CoV-2, inhibit viral replication 10–100 fold, and exhibit R0>1.

16 Nov 2021

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Scientists have hypothesized that the presence of regulatory sequences could be effectively used to instantaneously and accurately identify TRS sites as well as the related viral genes in unannotated coronavirus genomes.

16 Nov 2021

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

A new study has described the molecular basis of the neutralization potency and breadth of nanobodies.

16 Nov 2021

Diagnostic sensitivity, viral load and infectivity of SARS-CoV-2 in paired respiratory and oral samples

To understand the viral load in different sections of infected individuals, their respective shedding patterns, and the sensitivity of the SARS-CoV-2 assays, researchers published a study.

16 Nov 2021

Rapid thermal cycling approach for the detection of SARS-CoV-2

Researchers develop an ultrafast detection method for SARS-CoV-2 by direct RT-PCR without RNA extraction that is suitable for large-scale use.

15 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs (lncRNAs) – which are understudied in cancer research.

15 Nov 2021

RNA News and Research

Further Reading

Researchers identify never-before-defined subtypes of a blood cancer

Study may help predict genomic changes that may happen in advanced cancers based on therapy

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

Game animals as potential drivers of disease emergence

Urinary SARS-CoV-2 RNA is a prognosticator of COVID-19

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

What genes affect the COVID-19 gender imbalance?

Study: Covid-19 vaccine-elicited immune cells persist six months after vaccination

A therapeutic interfering particle for SARS-CoV-2

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

Diagnostic sensitivity, viral load and infectivity of SARS-CoV-2 in paired respiratory and oral samples

Rapid thermal cycling approach for the detection of SARS-CoV-2

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

Research expands the general understanding of transcription process in bacteria

Could drugs derived from microalgae be effective against COVID-19?

SARS-CoV-2 infection inhibited by CCR2 signaling

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

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