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Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

A new study aimed to examine the antiviral potential of atovaquone against the original SARS-CoV-2 strain and other variants of concern.

25 Oct 2021

How pregnancy influences SARS-CoV-2 immune response

A focus article published in Science Translational Medicine highlighted two recently published studies that investigated the response of pregnant women to natural infections and COVID-19 vaccines.

25 Oct 2021

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

A heart attack kills heart muscle cells, leading to a scar that weakens the heart, often leading to eventual heart failure. The lack of muscle repair is due to the very limited ability of mammalian heart muscle cells to proliferate, except for a brief period around birth.

25 Oct 2021

SARS-CoV-2 Delta variant transmitted by fully vaccinated individuals in Provincetown, Massachusetts

A new study, posted to the medRxiv* preprint server, describes the genomic epidemiology of this outbreak. It provides a deeper understanding of viral transmission from and between fully vaccinated individuals.

25 Oct 2021

Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Researchers discuss mutations in the NTD of the spike protein, which contains an antigenic “supersite” and is the target for nAbs.

24 Oct 2021

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

Researchers compare a large cohort of transcriptomic dataset maps of gene regulation by SARS-CoV-2 infection.

24 Oct 2021

Machine learning approach effective in predicting antibiotic resistance spread

Genes aren't only inherited through birth. Bacteria have the ability to pass genes to each other, or pick them up from their environment, through a process called horizonal gene transfer, which is a major culprit in the spread of antibiotic resistance.

22 Oct 2021

Researchers unravel the molecular origins of recombination in RNA viruses

An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses.

22 Oct 2021

Bacteria defend themselves against viral predators with exchangeable genetic elements

Bacterial viruses, so-called phages, destroy bacteria. Bacteria are constantly exposed to viral attacks. A research team led by Martin Polz, a microbiologist at the University of Vienna, has now studied how bacteria defend themselves against viral predators.

22 Oct 2021

Antisocial and prosocial behavior during COVID-19

A new study aims to determine whether individuals with antisocial behaviors are more susceptible to COVID-19.

21 Oct 2021

Influence of age on innate and adaptive immunity in COVID-19 patients

A new study investigates how age influences SARS-CoV-2 replication, innate and adaptive immune responses.

21 Oct 2021

Cell-free DNA can help detect measurable residual disease in children with medulloblastoma

Scientists at St. Jude Children's Research Hospital have shown that cell-free DNA from cerebrospinal fluid (CSF) can be used to detect measurable residual disease (MRD) in children treated for the brain tumor medulloblastoma.

21 Oct 2021

Underexpression of specific metabolic enzyme is a common feature in kidney cancer, study shows

A team of investigators has discovered that the underexpression of a specific metabolic enzyme is a common and adverse epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), according to a recent study published in Proceedings of the National Academy of Sciences.

20 Oct 2021

New research on phagocytosis and SARS-CoV-2's spike protein

A new study showed that convalescent patient plasma and monoclonal anti-spike antibodies were able to induce phagocytosis at high antibody concentrations.

20 Oct 2021

Safety and oral immunogenicity of a VSV-derived mucosal vaccine against SARS-CoV-2

A team of researchers exploited the known tropism of vesicular stomatitis virus to develop an oral vaccine that expresses the immunogenic SARS-CoV-2 spike glycoprotein in the oral mucosa.

20 Oct 2021

The effect of a SARS-CoV-2 delta variant mutation associated with higher viral loads

A new study has focused on the effect of a deletion found in the genome of the SARS-CoV-2 Delta variant that has severely reduced the amplification of ARTIC V3 amplicon 72.

20 Oct 2021

Researchers identify new gene variants that may cause inherited retinal dystrophies

An international team of researchers, led by scientists at University of California San Diego and Shiley Eye Institute at UC San Diego Health, has broadened and deepened understanding of how inherited retinal dystrophies (IRDs) affect different populations of people and, in the process, have identified new gene variants that may cause the diseases.

20 Oct 2021

New approach to predict the enzyme activity using AI

Without enzymes, an organism would not be able to survive. It is these biocatalysts that facilitate a whole range of chemical reactions, producing the building blocks of the cells. Enzymes are also used widely in biotechnology and in our households, where they are used in detergents, for example.

20 Oct 2021

Review shows UV radiation in HVAC systems inactivates viruses

The researchers followed international standards for systematic reviews, performed a comprehensive search, and gathered findings from 32 relevant studies published between 1936 and 2020. This study is published on the medRxiv* preprint server.

20 Oct 2021

Genetic testing in siblings of newborns with cancer susceptibility genes could reduce deaths by 50%

Genetic testing of the siblings of newborns found to have mutations in any one of 11 genes most commonly associated with childhood-onset cancers could reduce deaths from these rare cancers by about 50%, suggests a study funded by the National Institutes of Health.

19 Oct 2021

Genome News and Research

Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

How pregnancy influences SARS-CoV-2 immune response

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

SARS-CoV-2 Delta variant transmitted by fully vaccinated individuals in Provincetown, Massachusetts

Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Mapping the molecular gene signatures of respiratory viruses, including SARS-CoV-2

Machine learning approach effective in predicting antibiotic resistance spread

Researchers unravel the molecular origins of recombination in RNA viruses

Bacteria defend themselves against viral predators with exchangeable genetic elements

Antisocial and prosocial behavior during COVID-19

Influence of age on innate and adaptive immunity in COVID-19 patients

Cell-free DNA can help detect measurable residual disease in children with medulloblastoma

Underexpression of specific metabolic enzyme is a common feature in kidney cancer, study shows

New research on phagocytosis and SARS-CoV-2's spike protein

Safety and oral immunogenicity of a VSV-derived mucosal vaccine against SARS-CoV-2

The effect of a SARS-CoV-2 delta variant mutation associated with higher viral loads

Researchers identify new gene variants that may cause inherited retinal dystrophies

New approach to predict the enzyme activity using AI

Review shows UV radiation in HVAC systems inactivates viruses

Genetic testing in siblings of newborns with cancer susceptibility genes could reduce deaths by 50%

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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